-
1
-
-
68849111675
-
Hepatitis C virus versus innate and adaptive immune responses: A tale of coevolution and coexistence
-
Rehermann B (2009) Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest 119: 1745-1754.
-
(2009)
J Clin Invest
, vol.119
, pp. 1745-1754
-
-
Rehermann, B.1
-
2
-
-
32544459770
-
Restoring function in exhausted CD8 T cells during chronic viral infection
-
Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, et al. (2006) Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439: 682-687.
-
(2006)
Nature
, vol.439
, pp. 682-687
-
-
Barber, D.L.1
Wherry, E.J.2
Masopust, D.3
Zhu, B.4
Allison, J.P.5
-
3
-
-
33947407689
-
Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression
-
Radziewicz H, Ibegbu CC, Fernandez ML, Workowski KA, Obideen K, et al. (2007) Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. J Virol 81: 2545-2553.
-
(2007)
J Virol
, vol.81
, pp. 2545-2553
-
-
Radziewicz, H.1
Ibegbu, C.C.2
Fernandez, M.L.3
Workowski, K.A.4
Obideen, K.5
-
4
-
-
33947421722
-
Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection
-
Penna A, Pilli M, Zerbini A, Orlandini A, Mezzadri S, et al. (2007) Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection. Hepatology 45: 588-601.
-
(2007)
Hepatology
, vol.45
, pp. 588-601
-
-
Penna, A.1
Pilli, M.2
Zerbini, A.3
Orlandini, A.4
Mezzadri, S.5
-
5
-
-
44649188658
-
Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization
-
Nakamoto N, Kaplan DE, Coleclough J, Li Y, Valiga ME, et al. (2008) Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology 134: 1927-1937, 1937 e1921-1922.
-
(2008)
Gastroenterology 134: 1927-1937
, vol.1937
-
-
Nakamoto, N.1
Kaplan, D.E.2
Coleclough, J.3
Li, Y.4
Valiga, M.E.5
-
6
-
-
61449181280
-
Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade
-
Nakamoto N, Cho H, Shaked A, Olthoff K, Valiga ME, et al. (2009) Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. PLoS Pathog 5: e1000313.
-
(2009)
PLoS Pathog
, vol.e1000313
, pp. 5
-
-
Nakamoto, N.1
Cho, H.2
Shaked, A.3
Olthoff, K.4
Valiga, M.E.5
-
7
-
-
40149094779
-
High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome
-
Kasprowicz V, Schulze Zur Wiesch J, Kuntzen T, Nolan BE, Longworth S, et al. (2008) High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. J Virol 82: 3154-3160.
-
(2008)
J Virol
, vol.82
, pp. 3154-3160
-
-
Kasprowicz, V.1
Wiesch, J.S.Z.2
Kuntzen, T.3
Nolan, B.E.4
Longworth, S.5
-
8
-
-
43249095801
-
Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection
-
Bowen DG, Shoukry NH, Grakoui A, Fuller MJ, Cawthon AG, et al. (2008) Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. J Virol 82: 5109-5114.
-
(2008)
J Virol
, vol.82
, pp. 5109-5114
-
-
Bowen, D.G.1
Shoukry, N.H.2
Grakoui, A.3
Fuller, M.J.4
Cawthon, A.G.5
-
9
-
-
57849168934
-
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
-
Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, et al. (2009) Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol 10: 29-37.
-
(2009)
Nat Immunol
, vol.10
, pp. 29-37
-
-
Blackburn, S.D.1
Shin, H.2
Haining, W.N.3
Zou, T.4
Workman, C.J.5
-
10
-
-
50949109512
-
Molecular basis of the dual functions of 2B4 (CD244)
-
Chlewicki LK, Velikovsky CA, Balakrishnan V, Mariuzza RA, Kumar V (2008) Molecular basis of the dual functions of 2B4 (CD244). J Immunol 180: 8159-8167.
-
(2008)
J Immunol
, vol.180
, pp. 8159-8167
-
-
Chlewicki, L.K.1
Velikovsky, C.A.2
Balakrishnan, V.3
Mariuzza, R.A.4
Kumar, V.5
-
11
-
-
38349149016
-
CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator
-
Cai G, Anumanthan A, Brown JA, Greenfield EA, Zhu B, et al. (2008) CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator. Nat Immunol 9: 176-185.
-
(2008)
Nat Immunol
, vol.9
, pp. 176-185
-
-
Cai, G.1
Anumanthan, A.2
Brown, J.A.3
Greenfield, E.A.4
Zhu, B.5
-
12
-
-
35349014587
-
Molecular signature of CD8+ T cell exhaustion during chronic viral infection
-
Wherry EJ, Ha SJ, Kaech SM, Haining WN, Sarkar S, et al. (2007) Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity 27: 670-684.
-
(2007)
Immunity
, vol.27
, pp. 670-684
-
-
Wherry, E.J.1
Ha, S.J.2
Kaech, S.M.3
Haining, W.N.4
Sarkar, S.5
-
13
-
-
69249238113
-
KLRG1 signaling induces defective Akt (ser473) phosphorylation and prolifer-ative dysfunction of highly differentiated CD8+ T cells
-
Henson SM, Franzese O, Macaulay R, Libri V, Azevedo RI, et al. (2009) KLRG1 signaling induces defective Akt (ser473) phosphorylation and prolifer-ative dysfunction of highly differentiated CD8+ T cells. Blood 113: 6619- 6628.
-
(2009)
Blood 113: 6619-
, pp. 6628
-
-
Henson, S.M.1
Franzese, O.2
Macaulay, R.3
Libri, V.4
Azevedo, R.I.5
-
14
-
-
59749090805
-
Interaction of KLRG1 with E-cadherin: New functional and structural insights
-
Rosshart S, Hofmann M, Schweier O, Pfaff AK, Yoshimoto K, et al. (2008) Interaction of KLRG1 with E-cadherin: new functional and structural insights. Eur J Immunol 38: 3354-3364.
-
(2008)
Eur J Immunol
, vol.38
, pp. 3354-3364
-
-
Rosshart, S.1
Hofmann, M.2
Schweier, O.3
Pfaff, A.K.4
Yoshimoto, K.5
-
15
-
-
0035500504
-
Viral infections induce abundant numbers of senescent CD8 T cells
-
Voehringer D, Blaser C, Brawand P, Raulet DH, Hanke T, et al. (2001) Viral infections induce abundant numbers of senescent CD8 T cells. J Immunol 167: 4838-4843.
-
(2001)
J Immunol
, vol.167
, pp. 4838-4843
-
-
Voehringer, D.1
Blaser, C.2
Brawand, P.3
Raulet, D.H.4
Hanke, T.5
-
16
-
-
24644513769
-
Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation
-
Thimme R, Appay V, Koschella M, Panther E, Roth E, et al. (2005) Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. J Virol 79: 12112-12116.
-
(2005)
J Virol
, vol.79
, pp. 12112-12116
-
-
Thimme, R.1
Appay, V.2
Koschella, M.3
Panther, E.4
Roth, E.5
-
17
-
-
33846090225
-
Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver
-
Bengsch B, Spangenberg HC, Kersting N, Neumann-Haefelin C, Panther E, et al. (2007) Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver. J Virol 81: 945-953.
-
(2007)
J Virol
, vol.81
, pp. 945-953
-
-
Bengsch, B.1
Spangenberg, H.C.2
Kersting, N.3
Neumann-Haefelin, C.4
Panther, E.5
-
18
-
-
55949116720
-
Phenotype and function of human T lymphocyte subsets: Consensus and issues
-
Appay V, van Lier RA, Sallusto F, Roederer M (2008) Phenotype and function of human T lymphocyte subsets: consensus and issues. Cytometry A 73: 975-983.
-
(2008)
Cytometry A
, vol.73
, pp. 975-983
-
-
Appay, V.1
van Lier, R.A.2
Sallusto, F.3
Roederer, M.4
-
19
-
-
34648828497
-
PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status
-
Sauce D, Almeida JR, Larsen M, Haro L, Autran B, et al. (2007) PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status. AIDS 21: 2005-2013.
-
(2007)
AIDS
, vol.21
, pp. 2005-2013
-
-
Sauce, D.1
Almeida, J.R.2
Larsen, M.3
Haro, L.4
Autran, B.5
-
20
-
-
25844470442
-
Intrahepatic CD8+ T-cell failure during chronic hepatitis C virus infection
-
Spangenberg HC, Viazov S, Kersting N, Neumann-Haefelin C, McKinney D, et al. (2005) Intrahepatic CD8+ T-cell failure during chronic hepatitis C virus infection. Hepatology 42: 828-837.
-
(2005)
Hepatology
, vol.42
, pp. 828-837
-
-
Spangenberg, H.C.1
Viazov, S.2
Kersting, N.3
Neumann-Haefelin, C.4
McKinney, D.5
-
21
-
-
0037105567
-
Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection
-
Wedemeyer H, He XS, Nascimbeni M, Davis AR, Greenberg HB, et al. (2002) Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection. J Immunol 169: 3447-3458.
-
(2002)
J Immunol
, vol.169
, pp. 3447-3458
-
-
Wedemeyer, H.1
He, X.S.2
Nascimbeni, M.3
Davis, A.R.4
Greenberg, H.B.5
-
22
-
-
34548191951
-
Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction
-
Golden-Mason L, Palmer B, Klarquist J, Mengshol JA, Castelblanco N, et al. (2007) Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. J Virol 81: 9249-9258.
-
(2007)
J Virol
, vol.81
, pp. 9249-9258
-
-
Golden-Mason, L.1
Palmer, B.2
Klarquist, J.3
Mengshol, J.A.4
Castelblanco, N.5
-
23
-
-
34247892632
-
Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules
-
Ma CS, Nichols KE, Tangye SG (2007) Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules. Annu Rev Immunol 25: 337-379.
-
(2007)
Annu Rev Immunol
, vol.25
, pp. 337-379
-
-
Ma, C.S.1
Nichols, K.E.2
Tangye, S.G.3
-
24
-
-
0035576393
-
The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells
-
Speiser DE, Colonna M, Ayyoub M, Cella M, Pittet MJ, et al. (2001) The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells. J Immunol 167: 6165-6170.
-
(2001)
J Immunol
, vol.167
, pp. 6165-6170
-
-
Speiser, D.E.1
Colonna, M.2
Ayyoub, M.3
Cella, M.4
Pittet, M.J.5
-
25
-
-
34548027000
-
Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor
-
Joshi NS, Cui W, Chandele A, Lee HK, Urso DR, et al. (2007) Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity 27: 281-295.
-
(2007)
Immunity
, vol.27
, pp. 281-295
-
-
Joshi, N.S.1
Cui, W.2
Chandele, A.3
Lee, H.K.4
Urso, D.R.5
-
26
-
-
67649660551
-
Redefining chronic viral infection
-
Virgin HW, Wherry EJ, Ahmed R (2009) Redefining chronic viral infection. Cell 138: 30-50.
-
(2009)
Cell
, vol.138
, pp. 30-50
-
-
Virgin, H.W.1
Wherry, E.J.2
Ahmed, R.3
-
27
-
-
66649114758
-
High antigen levels are the cause of T cell exhaustion during chronic viral infection
-
Mueller SN, Ahmed R (2009) High antigen levels are the cause of T cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A 106: 8623-8628.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 8623-8628
-
-
Mueller, S.N.1
Ahmed, R.2
-
28
-
-
0036109159
-
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
-
Appay V, Dunbar PR, Callan M, Klenerman P, Gillespie GM, et al. (2002) Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med 8: 379-385.
-
(2002)
Nat Med
, vol.8
, pp. 379-385
-
-
Appay, V.1
Dunbar, P.R.2
Callan, M.3
Klenerman, P.4
Gillespie, G.M.5
-
29
-
-
77954668895
-
-
Rey J, Giustiniani J, Mallet F, Schiavon V, Boumsell L, et al. (2006) The co-expression of 2B4 (CD244) and CD160 delineates a subpopulation of human
-
(2006)
The Co-expression of 2B4 (CD244) and CD160 Delineates a Subpopulation of Human
-
-
Rey, J.1
Giustiniani, J.2
Mallet, F.3
Schiavon, V.4
Boumsell, L.5
-
30
-
-
33748846543
-
CD8+ T cells with a potent CD160-mediated cytolytic effector function
-
CD8+ T cells with a potent CD160-mediated cytolytic effector function. Eur J Immunol 36: 2359-2366.
-
Eur J Immunol
, vol.36
, pp. 2359-2366
-
-
-
31
-
-
53749106026
-
Early interferon therapy for hepatitis C virus infection rescues polyfunctional, long-lived CD8+ memory T cells
-
Badr G, Bedard N, Abdel-Hakeem MS, Trautmann L, Willems B, et al. (2008) Early interferon therapy for hepatitis C virus infection rescues polyfunctional, long-lived CD8+ memory T cells. J Virol 82: 10017-10031.
-
(2008)
J Virol
, vol.82
, pp. 10017-10031
-
-
Badr, G.1
Bedard, N.2
Abdel-Hakeem, M.S.3
Trautmann, L.4
Willems, B.5
-
32
-
-
33750994934
-
Loss of IL-7 receptor alpha-chain (CD127) expression in acute HCV infection associated with viral persistence
-
Golden-Mason L, Burton JR, Jr., Castelblanco N, Klarquist J, Benlloch S, et al. (2006) Loss of IL-7 receptor alpha-chain (CD127) expression in acute HCV infection associated with viral persistence. Hepatology 44: 1098-1109.
-
(2006)
Hepatology
, vol.44
, pp. 1098-1109
-
-
Golden-Mason, L.1
Burton Jr., J.R.2
Castelblanco, N.3
Klarquist, J.4
Benlloch, S.5
-
33
-
-
77954677282
-
HCV sequence variation induces an HCV-specific T cell phenotype analogous to spontaneous resolution
-
Kasprowicz V, Kang YH, Lucas M, Schulze Zur Wiesch J, Kuntzen T, et al. (2009) HCV sequence variation induces an HCV-specific T cell phenotype analogous to spontaneous resolution. J Virol.
-
(2009)
J Virol
-
-
Kasprowicz, V.1
Kang, Y.H.2
Lucas, M.3
Wiesch, J.S.Z.4
Kuntzen, T.5
-
34
-
-
58849105469
-
High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection
-
Rutebemberwa A, Ray SC, Astemborski J, Levine J, Liu L, et al. (2008) High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection. J Immunol 181: 8215-8225.
-
(2008)
J Immunol
, vol.181
, pp. 8215-8225
-
-
Rutebemberwa, A.1
Ray, S.C.2
Astemborski, J.3
Levine, J.4
Liu, L.5
-
35
-
-
66149123225
-
Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection
-
Blattman JN, Wherry EJ, Ha SJ, van der Most RG, Ahmed R (2009) Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection. J Virol 83: 4386-4394.
-
(2009)
J Virol
, vol.83
, pp. 4386-4394
-
-
Blattman, J.N.1
Wherry, E.J.2
Ha, S.J.3
van der Most, R.G.4
Ahmed, R.5
-
36
-
-
44449096577
-
Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells
-
Streeck H, Brumme ZL, Anastario M, Cohen KW, Jolin JS, et al. (2008) Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells. PLoS Med 5: e100.
-
(2008)
PLoS Med
, vol.e100
, pp. 5
-
-
Streeck, H.1
Brumme, Z.L.2
Anastario, M.3
Cohen, K.W.4
Jolin, J.S.5
-
37
-
-
21344442507
-
Cellular immune selection with hepatitis C virus persistence in humans
-
Cox AL, Mosbruger T, Mao Q, Liu Z, Wang XH, et al. (2005) Cellular immune selection with hepatitis C virus persistence in humans. J Exp Med 201: 1741-1752.
-
(2005)
J Exp Med
, vol.201
, pp. 1741-1752
-
-
Cox, A.L.1
Mosbruger, T.2
Mao, Q.3
Liu, Z.4
Wang, X.H.5
-
38
-
-
46249090636
-
Virological and immunological determinants of intrahepatic virus-specific CD8+ T-cell failure in chronic hepatitis C virus infection
-
Neumann-Haefelin C, Timm J, Spangenberg HC, Wischniowski N, Nazarova N, et al. (2008) Virological and immunological determinants of intrahepatic virus-specific CD8+ T-cell failure in chronic hepatitis C virus infection. Hepatology 47: 1824-1836.
-
(2008)
Hepatology
, vol.47
, pp. 1824-1836
-
-
Neumann-Haefelin, C.1
Timm, J.2
Spangenberg, H.C.3
Wischniowski, N.4
Nazarova, N.5
-
39
-
-
34447544075
-
Optimizing a multicolor immunophenotyping assay
-
Mahnke YD, Roederer M, (2007) Optimizing a multicolor immunophenotyping assay. Clin Lab Med 27: 469-485, v.
-
(2007)
Clin Lab Med
, vol.27
, pp. 469-485
-
-
Mahnke, Y.D.1
Roederer, M.2
-
40
-
-
46349100543
-
Cross-genotype-reactivity of the immunodominant HCV CD8 T-cell epitope NS3-1073
-
Fytili P, Dalekos GN, Schlaphoff V, Suneetha PV, Sarrazin C, et al. (2008) Cross-genotype-reactivity of the immunodominant HCV CD8 T-cell epitope NS3-1073. Vaccine 26: 3818-3826.
-
(2008)
Vaccine
, vol.26
, pp. 3818-3826
-
-
Fytili, P.1
Dalekos, G.N.2
Schlaphoff, V.3
Suneetha, P.V.4
Sarrazin, C.5
|