메뉴 건너뛰기




Volumn 33, Issue 2, 2010, Pages 136-145

Combining T-cell vaccination and application of agonistic anti-GITR mAb (DTA-1) induces complete eradication of HPV oncogene expressing tumors in mice

Author keywords

Adenovirus; Cervical cancer; GITR receptor; HPV; Papillomavirus oncogenes; Therapeutic vaccine

Indexed keywords

ADENOVIRUS VECTOR; CANCER VACCINE; CD4 ANTIBODY; DTA 1; EPITOPE; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR ANTIBODY; IMIQUIMOD; MONOCLONAL ANTIBODY; PROTEIN E6; PROTEIN E7; RECEPTOR ANTIBODY; RECOMBINANT ALPHA2A INTERFERON; T LYMPHOCYTE VACCINE; UNCLASSIFIED DRUG;

EID: 77649093452     PISSN: 15249557     EISSN: None     Source Type: Journal    
DOI: 10.1097/CJI.0b013e3181badc46     Document Type: Article
Times cited : (35)

References (61)
  • 1
    • 0025977595 scopus 로고
    • Prevalence of human papillomavirus genomes in tissues from the lower genital tract as detected by molecular in situ hybridization
    • Schneider A, Meinhardt G, Kirchmayr R, et al. Prevalence of human papillomavirus genomes in tissues from the lower genital tract as detected by molecular in situ hybridization. Int J Gynecol Pathol. 1991;10:1-14.
    • (1991) Int J Gynecol Pathol , vol.10 , pp. 1-14
    • Schneider, A.1    Meinhardt, G.2    Kirchmayr, R.3
  • 2
    • 0023181357 scopus 로고
    • Human papillo-mavirus infections in women with and without abnormal cervical cytology
    • De Villiers EM, Wagner D, Schneider A, et al. Human papillo-mavirus infections in women with and without abnormal cervical cytology. Lancet. 1987;2:703-706.
    • (1987) Lancet , vol.2 , pp. 703-706
    • De Villiers, E.M.1    Wagner, D.2    Schneider, A.3
  • 3
    • 0035058211 scopus 로고    scopus 로고
    • Epidemiology and pathogenesis of cervical cancer
    • Fischer U, Raptis G, Gessner W, et al. Epidemiology and pathogenesis of cervical cancer. Zentralbl Gynakol. 2001;123: 198-205.
    • (2001) Zentralbl Gynakol , vol.123 , pp. 198-205
    • Fischer, U.1    Raptis, G.2    Gessner, W.3
  • 4
    • 0020601352 scopus 로고
    • CIN and preclinical cervical carcinoma. A study of morbidity trends over a 10-year period
    • Dietl J, Semm K, Hedderich J, et al. CIN and preclinical cervical carcinoma. A study of morbidity trends over a 10-year period. Int J Gynaecol Obstet. 1983;21:283-289.
    • (1983) Int J Gynaecol Obstet , vol.21 , pp. 283-289
    • Dietl, J.1    Semm, K.2    Hedderich, J.3
  • 6
    • 33646675570 scopus 로고    scopus 로고
    • Molecular biology of human papillomavirus infection and cervical cancer
    • Doorbar J. Molecular biology of human papillomavirus infection and cervical cancer. Clin Sci (Lond). 2006;110:525-541.
    • (2006) Clin Sci (Lond) , vol.110 , pp. 525-541
    • Doorbar, J.1
  • 7
    • 0033052752 scopus 로고    scopus 로고
    • Uniform distribution of HPV 16 E6 and E7 variants in patients with normal histology, cervical intra-epithelial neoplasia and cervical cancer
    • Nindl I, Rindfleisch K, Lotz B, et al. Uniform distribution of HPV 16 E6 and E7 variants in patients with normal histology, cervical intra-epithelial neoplasia and cervical cancer. Int J Cancer. 1999;82:203-207.
    • (1999) Int J Cancer , vol.82 , pp. 203-207
    • Nindl, I.1    Rindfleisch, K.2    Lotz, B.3
  • 8
    • 0038405322 scopus 로고    scopus 로고
    • Immunotherapy of human cervical high-grade cervical intraepithelial neoplasia with microparticle-delivered human papillomavirus 16 E7 plasmid DNA
    • Sheets EE, Urban RG, Crum CP et al. Immunotherapy of human cervical high-grade cervical intraepithelial neoplasia with microparticle-delivered human papillomavirus 16 E7 plasmid DNA. Am J Obstet Gynecol. 2003;181:916-926.
    • (2003) Am J Obstet Gynecol , vol.181 , pp. 916-926
    • Sheets, E.E.1    Urban, R.G.2    Crum, C.P.3
  • 9
    • 0037404796 scopus 로고    scopus 로고
    • Induction of tumor-specific cytotoxicity in tumor infiltrating lymphocytes by HPV16 and HPV18 E7-pulsed autologous dendritic cells in patients with cancer of the uterine cervix
    • DOI 10.1016/S0090-8258(03)00083-0
    • Santin AD, Bellone S, Palmieri M, et al. Induction of tumor-specific cytotoxicity in tumor infiltrating lymphocytes by HPV16 and HPV18 E7-pulsed autologous dendritic cells in patients with cancer of the uterine cervix. Gynecol Oncol. 2003;89:271-280. (Pubitemid 36457876)
    • (2003) Gynecologic Oncology , vol.89 , Issue.2 , pp. 271-280
    • Santin, A.D.1    Bellone, S.2    Palmieri, M.3    Bossini, B.4    Roman, J.J.5    Cannon, M.J.6    Bignotti, E.7    Cane, S.8    Pecorelli, S.9
  • 10
    • 0033813525 scopus 로고    scopus 로고
    • A phase i trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive
    • Muderspach L, Wilczynski S, Roman L, et al. A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive. Clin Cancer Res. 2000;6:3406-3416.
    • (2000) Clin Cancer Res , vol.6 , pp. 3406-3416
    • Muderspach, L.1    Wilczynski, S.2    Roman, L.3
  • 11
    • 36248945563 scopus 로고    scopus 로고
    • Vaccination trial with HPV16 L1E7 chimeric virus-like particles in women suffering from high grade cervical intraepithelial neoplasia (CIN 2/3)
    • Kaufmann AM, Nieland JD, Jochmus I, et al. Vaccination trial with HPV16 L1E7 chimeric virus-like particles in women suffering from high grade cervical intraepithelial neoplasia (CIN 2/3). Int J Cancer. 2007;121:2794-2800.
    • (2007) Int J Cancer , vol.121 , pp. 2794-2800
    • Kaufmann, A.M.1    Nieland, J.D.2    Jochmus, I.3
  • 12
    • 3042723816 scopus 로고    scopus 로고
    • Phase I/II trial of immunogenicity of a human papillomavirus (HPV) type 16 E7 protein-based vaccine in women with oncogenic HPV-positive cervical intraepithelial neoplasia
    • Hallez S, Simon P, Maudoux F, et al. Phase I/II trial of immunogenicity of a human papillomavirus (HPV) type 16 E7 protein-based vaccine in women with oncogenic HPV-positive cervical intraepithelial neoplasia. Cancer Immunol Immunother. 2004;53:642-650.
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 642-650
    • Hallez, S.1    Simon, P.2    Maudoux, F.3
  • 13
    • 33646817087 scopus 로고    scopus 로고
    • Regression of papilloma high-grade lesions (CIN 2 and CIN 3) is stimulated by therapeutic vaccination with MVA E2 recombinant vaccine
    • Garcia-Hernandez E, Gonzalez-Sanchez JL, Andrade-Manzano A, et al. Regression of papilloma high-grade lesions (CIN 2 and CIN 3) is stimulated by therapeutic vaccination with MVA E2 recombinant vaccine. Cancer Gene Ther. 2006;13:592-597.
    • (2006) Cancer Gene Ther , vol.13 , pp. 592-597
    • Garcia-Hernandez, E.1    Gonzalez-Sanchez, J.L.2    Andrade-Manzano, A.3
  • 14
    • 8644252813 scopus 로고    scopus 로고
    • Phase 1 study of HPV16-specific immunotherapy with E6E7 fusion protein and ISCOMATRIX adjuvant in women with cervical intraepithe-lial neoplasia
    • Frazer IH, Quinn M, Nicklin JL, et al. Phase 1 study of HPV16-specific immunotherapy with E6E7 fusion protein and ISCOMATRIX adjuvant in women with cervical intraepithe-lial neoplasia. Vaccine. 2004;23:172-181.
    • (2004) Vaccine , vol.23 , pp. 172-181
    • Frazer, I.H.1    Quinn, M.2    Nicklin, J.L.3
  • 15
    • 33745115850 scopus 로고    scopus 로고
    • Prime-boost vaccination strategy in women with high-grade, noncervical anogenital intraepithelial neoplasia: Clinical results from a multi-center phase II trial
    • Fiander AN, Tristram AJ, Davidson EJ, et al. Prime-boost vaccination strategy in women with high-grade, noncervical anogenital intraepithelial neoplasia: clinical results from a multi-center phase II trial. Int J Gynecol Cancer. 2006;16:1075-1081.
    • (2006) Int J Gynecol Cancer , vol.16 , pp. 1075-1081
    • Fiander, A.N.1    Tristram, A.J.2    Davidson, E.J.3
  • 16
    • 0141528515 scopus 로고    scopus 로고
    • Dendritic cell-based tumor vaccine for cervical cancer II: Results of a clinical pilot study in 15 individual patients
    • Ferrara A, Nonn M, Sehr P, et al. Dendritic cell-based tumor vaccine for cervical cancer II: results of a clinical pilot study in 15 individual patients. J Cancer Res Clin Oncol. 2003;129: 521-530.
    • (2003) J Cancer Res Clin Oncol , vol.129 , pp. 521-530
    • Ferrara, A.1    Nonn, M.2    Sehr, P.3
  • 17
    • 0037019901 scopus 로고    scopus 로고
    • Enhancement of human papillomavirus (HPV) type 16 E6 and E7-specific T-cell immunity in healthy volunteers through vaccination with TA-CIN, an HPV16 L2E7E6 fusion protein vaccine
    • de Jong A, O'Neill T, Khan AY, et al. Enhancement of human papillomavirus (HPV) type 16 E6 and E7-specific T-cell immunity in healthy volunteers through vaccination with TA-CIN, an HPV16 L2E7E6 fusion protein vaccine. Vaccine. 2002;20:3456-3464.
    • (2002) Vaccine , vol.20 , pp. 3456-3464
    • De Jong, A.1    O'Neill, T.2    Khan, A.Y.3
  • 19
    • 30344438861 scopus 로고    scopus 로고
    • Strategies of tumor immune evasion
    • Seliger B. Strategies of tumor immune evasion. BioDrugs. 2005;19:347-354.
    • (2005) BioDrugs , vol.19 , pp. 347-354
    • Seliger, B.1
  • 20
    • 33746092947 scopus 로고    scopus 로고
    • Immune suppression in the tumor microenvironment
    • Gajewski TF, Meng Y, Harlin H. Immune suppression in the tumor microenvironment. J Immunother. 2006;29:233-240.
    • (2006) J Immunother , vol.29 , pp. 233-240
    • Gajewski, T.F.1    Meng, Y.2    Harlin, H.3
  • 21
    • 33751536158 scopus 로고    scopus 로고
    • Immune selective pressure and HLA class i antigen defects in malignant lesions
    • Chang CC, Ferrone S. Immune selective pressure and HLA class I antigen defects in malignant lesions. Cancer Immunol Immunother. 2007;56:227-236.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 227-236
    • Chang, C.C.1    Ferrone, S.2
  • 22
    • 33847401888 scopus 로고    scopus 로고
    • Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: An update on implications for chronic infections and tumor evasion
    • Blank C, Mackensen A. Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion. Cancer Immunol Immunother. 2007;56:739-745.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 739-745
    • Blank, C.1    MacKensen, A.2
  • 23
    • 36549032065 scopus 로고    scopus 로고
    • Imiqimod: Mode of action
    • Schon MP, Schon M. Imiqimod: Mode of action. Br J Dermatol. 2007;157(suppl 2):8-13.
    • (2007) Br J Dermatol , vol.157 , Issue.SUPPL. 2 , pp. 8-13
    • Schon, M.P.1    Schon, M.2
  • 24
    • 19044390232 scopus 로고    scopus 로고
    • Imiquimod for the treatment of genital warts: A quantitative systematic review
    • Moore RA, Edwards JE, Hopwood J, et al. Imiquimod for the treatment of genital warts: a quantitative systematic review. BMC Infect Dis. 2001;1:3.
    • (2001) BMC Infect Dis , vol.1 , pp. 3
    • Moore, R.A.1    Edwards, J.E.2    Hopwood, J.3
  • 25
    • 15444377017 scopus 로고    scopus 로고
    • Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors
    • Yu P, Lee Y, Liu W, et al. Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors. J Exp Med. 2005;201:779-791.
    • (2005) J Exp Med , vol.201 , pp. 779-791
    • Yu, P.1    Lee, Y.2    Liu, W.3
  • 26
    • 52749083287 scopus 로고    scopus 로고
    • Biological basis for a proper clinical application of alpha-interferons
    • Antonelli G. Biological basis for a proper clinical application of alpha-interferons. New Microbiol. 2008;31:305-318.
    • (2008) New Microbiol , vol.31 , pp. 305-318
    • Antonelli, G.1
  • 27
    • 0037248784 scopus 로고    scopus 로고
    • Recombinant human interferon gamma in the treatment of cervical intraepithelial neoplasia (CIN) associated with human papillomavirus (HPV) infection
    • Sikorski M, Zrubek H. Recombinant human interferon gamma in the treatment of cervical intraepithelial neoplasia (CIN) associated with human papillomavirus (HPV) infection. Eur J Gynaecol Oncol. 2003;24:147-150. (Pubitemid 36389357)
    • (2003) European Journal of Gynaecological Oncology , vol.24 , Issue.2 , pp. 147-150
    • Sikorski, M.1    Zrubek, H.2
  • 28
    • 0025340029 scopus 로고
    • No effect of intralesional injection of interferon on moderate cervical intraepithelial neoplasia
    • Frost L, Skajaa K, Hvidman LE, et al. No effect of intralesional injection of interferon on moderate cervical intraepithelial neoplasia. Br J Obstet Gynaecol. 1990;97:626-630.
    • (1990) Br J Obstet Gynaecol , vol.97 , pp. 626-630
    • Frost, L.1    Skajaa, K.2    Hvidman, L.E.3
  • 29
    • 0026411167 scopus 로고
    • Systemic alpha-interferon (Wellferon) treatment of genital human papillomavirus (HPV) type 6, 11, 16, and 18 infections: Double-blind, placebo-controlled trial
    • Yliskoski M, Syrjanen K, Syrjanen S, et al. Systemic alpha-interferon (Wellferon) treatment of genital human papillomavirus (HPV) type 6, 11, 16, and 18 infections: double-blind, placebo-controlled trial. Gynecol Oncol. 1991; 43:55-60.
    • (1991) Gynecol Oncol , Issue.43 , pp. 55-60
    • Yliskoski, M.1    Syrjanen, K.2    Syrjanen, S.3
  • 30
    • 25844517914 scopus 로고    scopus 로고
    • Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells
    • Ko K, Yamazaki S, Nakamura K, et al. Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. J Exp Med. 2005;202:885-891.
    • (2005) J Exp Med , vol.202 , pp. 885-891
    • Ko, K.1    Yamazaki, S.2    Nakamura, K.3
  • 31
    • 33646876477 scopus 로고    scopus 로고
    • Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity
    • Ramirez-Montaqut T, Chow A, Hirschhorn-Cymerman D, et al. Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity. J Immunol. 2006;176:6434-6442.
    • (2006) J Immunol , vol.176 , pp. 6434-6442
    • Ramirez-Montaqut, T.1    Chow, A.2    Hirschhorn-Cymerman, D.3
  • 32
    • 59149095895 scopus 로고    scopus 로고
    • Glucocorticoid-induced tumor necrosis factor receptor-related protein ligand subverts immunosurveillance of acute myeloid leukemia in humans
    • Baessler T, Krusch M, Schmiedel BJ, et al. Glucocorticoid-induced tumor necrosis factor receptor-related protein ligand subverts immunosurveillance of acute myeloid leukemia in humans. Cancer Res. 2009;69:1037-1045.
    • (2009) Cancer Res , vol.69 , pp. 1037-1045
    • Baessler, T.1    Krusch, M.2    Schmiedel, B.J.3
  • 33
    • 43749101844 scopus 로고    scopus 로고
    • Glucocorticoid-induced tumor necrosis factor receptor negatively regulates activation of human primary natural killer (NK) cells by blocking pro-liferative signals and increasing NK cell apoptosis
    • Liu B, Li Z, Mahesh SP, et al. Glucocorticoid-induced tumor necrosis factor receptor negatively regulates activation of human primary natural killer (NK) cells by blocking pro-liferative signals and increasing NK cell apoptosis. J Biol Chem. 2008;283:2802-2810.
    • (2008) J Biol Chem , vol.283 , pp. 2802-2810
    • Liu, B.1    Li, Z.2    Mahesh, S.P.3
  • 34
    • 34547791385 scopus 로고    scopus 로고
    • Cancer immuno-editing by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions
    • Baltz KM, Krusch M, Bringmann A, et al. Cancer immuno-editing by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions. FASEB J. 2007;21:2442-2454.
    • (2007) FASEB J , vol.21 , pp. 2442-2454
    • Baltz, K.M.1    Krusch, M.2    Bringmann, A.3
  • 35
    • 12344253083 scopus 로고    scopus 로고
    • The role of human papilloma virus in the molecular biology of cervical carcinogenesis
    • Motoyama S, Ladines-Llave CA, Luis VS, et al. The role of human papilloma virus in the molecular biology of cervical carcinogenesis. Kobe J Med Sci. 2004;50:9-19.
    • (2004) Kobe J Med Sci , vol.50 , pp. 9-19
    • Motoyama, S.1    Ladines-Llave, C.A.2    Luis, V.S.3
  • 36
    • 0033552585 scopus 로고    scopus 로고
    • The role of the E6-p53 interaction in the molecular pathogenesis of HPV
    • Thomas M, Pim D, Banks L. The role of the E6-p53 interaction in the molecular pathogenesis of HPV. Oncogene. 1999;18:7690-7700.
    • (1999) Oncogene , vol.18 , pp. 7690-7700
    • Thomas, M.1    Pim, D.2    Banks, L.3
  • 37
    • 0032484989 scopus 로고    scopus 로고
    • Retinoblastoma protein recruits histone deacetylase to repress transcription
    • Brehm A, Miska EA, McCance DJ, et al. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature. 1998;391:597-601.
    • (1998) Nature , vol.391 , pp. 597-601
    • Brehm, A.1    Miska, E.A.2    McCance, D.J.3
  • 38
    • 0030008177 scopus 로고    scopus 로고
    • Telomerase activation by the E6 gene product of human papillomavirus type 16
    • Klingelhutz AJ, Foster SA, McDougall JK. Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature. 1996;380:79-82.
    • (1996) Nature , vol.380 , pp. 79-82
    • Klingelhutz, A.J.1    Foster, S.A.2    McDougall, J.K.3
  • 39
    • 0027169680 scopus 로고
    • Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins
    • Huibregtse JM, Scheffner M, Howley PM. Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins. Mol Cell Biol. 1993;13:4918-4927.
    • (1993) Mol Cell Biol , vol.13 , pp. 4918-4927
    • Huibregtse, J.M.1    Scheffner, M.2    Howley, P.M.3
  • 40
    • 0025863108 scopus 로고
    • Two immunodominant regions of the human papillomavirus type 16 E7 protein are masked in the nuclei of monkey COS-1 cells
    • Kanda T, Zanma S, Watanabe S, et al. Two immunodominant regions of the human papillomavirus type 16 E7 protein are masked in the nuclei of monkey COS-1 cells. Virology. 1991; 182:723-731.
    • (1991) Virology , vol.182 , pp. 723-731
    • Kanda, T.1    Zanma, S.2    Watanabe, S.3
  • 41
    • 0029968641 scopus 로고    scopus 로고
    • Serum-and calcium-induced differentiation of human keratinocytes is inhibited by the E6 oncoprotein of human papillomavirus type 16
    • Sherman L, Schlegel R. Serum-and calcium-induced differentiation of human keratinocytes is inhibited by the E6 oncoprotein of human papillomavirus type 16. J Virol. 1996; 70:3269-3279.
    • (1996) J Virol , vol.70 , pp. 3269-3279
    • Sherman, L.1    Schlegel, R.2
  • 42
    • 0030950410 scopus 로고    scopus 로고
    • Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein
    • Lee SS, Weiss RS, Javier RT. Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein. Proc Natl Acad Sci USA. 1997;94:6670-6675.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 6670-6675
    • Lee, S.S.1    Weiss, R.S.2    Javier, R.T.3
  • 43
    • 0030774987 scopus 로고    scopus 로고
    • Binding of high-risk human papillomavirus E6 oncoproteins to the human homo-logue of the Drosophila discs large tumor suppressor protein
    • Kiyono T, Hiraiwa A, Fujita M, et al. Binding of high-risk human papillomavirus E6 oncoproteins to the human homo-logue of the Drosophila discs large tumor suppressor protein. Proc Natl Acad Sci USA. 1997;94:11612-11616.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 11612-11616
    • Kiyono, T.1    Hiraiwa, A.2    Fujita, M.3
  • 44
    • 33947412686 scopus 로고    scopus 로고
    • Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: Mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein
    • Zhang Y, Dasgupta J, Ma RZ, et al. Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein. J Virol. 2007;81:3618-3626
    • (2007) J Virol , vol.81 , pp. 3618-3626
    • Zhang, Y.1    Dasgupta, J.2    Ma, R.Z.3
  • 45
    • 0027359827 scopus 로고
    • WAF1, a potential mediator of p53 tumor suppression
    • el Deiry WS, Tokino T, Velculescu VE, et al. WAF1, a potential mediator of p53 tumor suppression. Cell. 1993;75:817-825.
    • (1993) Cell , vol.75 , pp. 817-825
    • El Deiry, W.S.1    Tokino, T.2    Velculescu, V.E.3
  • 46
    • 0028176483 scopus 로고
    • Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
    • Polyak K, Lee MH, Erdjument-Bromage H, et al. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 1994;78:59-66.
    • (1994) Cell , vol.78 , pp. 59-66
    • Polyak, K.1    Lee, M.H.2    Erdjument-Bromage, H.3
  • 47
    • 0034597533 scopus 로고    scopus 로고
    • Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins
    • Glaunsinger BA, Lee SS, Thomas M, et al. Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins. Oncogene. 2000;19:5270-5280.
    • (2000) Oncogene , vol.19 , pp. 5270-5280
    • Glaunsinger, B.A.1    Lee, S.S.2    Thomas, M.3
  • 49
    • 15844365301 scopus 로고    scopus 로고
    • A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer
    • Borysiewicz LK, Fiander A, Nimako M, et al. A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer. Lancet. 1996;347:1523-1527.
    • (1996) Lancet , Issue.347 , pp. 1523-1527
    • Borysiewicz, L.K.1    Fiander, A.2    Nimako, M.3
  • 50
    • 0030068375 scopus 로고    scopus 로고
    • Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen
    • Lin KY, Guarnieri FG, Staveley-O'Carroll KF, et al. Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen. Cancer Res. 1996;56:21-26.
    • (1996) Cancer Res. , vol.56 , pp. 21-26
    • Lin, K.Y.1    Guarnieri, F.G.2    Staveley-O'Carroll, K.F.3
  • 51
    • 0035866607 scopus 로고    scopus 로고
    • Modified HPV16 E7 genes as DNA vaccine against E7-containing oncogenic cells
    • Smahel M, Sima P, Ludvikova V, et al. Modified HPV16 E7 genes as DNA vaccine against E7-containing oncogenic cells. Virology. 2001;281:231-238.
    • (2001) Virology , vol.281 , pp. 231-238
    • Smahel, M.1    Sima, P.2    Ludvikova, V.3
  • 52
    • 33644888264 scopus 로고    scopus 로고
    • An improved rearranged Human Papillomavirus Type 16 E7 DNA vaccine candidate (HPV-16 E7SH) induces an E7 wildtype-specific T cell response
    • Ohlschlager P, Pes M, Osen W, et al. An improved rearranged Human Papillomavirus Type 16 E7 DNA vaccine candidate (HPV-16 E7SH) induces an E7 wildtype-specific T cell response. Vaccine. 2006;24:2880-2893.
    • (2006) Vaccine , vol.24 , pp. 2880-2893
    • Ohlschlager, P.1    Pes, M.2    Osen, W.3
  • 53
    • 0034751496 scopus 로고    scopus 로고
    • Foreign DNA integration perturbations of the genome-oncogenesis
    • Doerfler W, Hohlweg U, Muller K, et al. Foreign DNA integration perturbations of the genome-oncogenesis. Ann N Y Acad Sci. 2001;945:276-288.
    • (2001) Ann N y Acad Sci , vol.945 , pp. 276-288
    • Doerfler, W.1    Hohlweg, U.2    Muller, K.3
  • 54
    • 33645016634 scopus 로고    scopus 로고
    • Tissue distribution of a plasmid DNA encoding Hsp65 gene is dependent on the dose administered through intramuscular delivery
    • Coelho-Castelo AA, Trombone AP, Rosada RS, et al. Tissue distribution of a plasmid DNA encoding Hsp65 gene is dependent on the dose administered through intramuscular delivery. Genet Vaccines Ther. 2006;4:1.
    • (2006) Genet Vaccines Ther , vol.4 , pp. 1
    • Coelho-Castelo, A.A.1    Trombone, A.P.2    Rosada, R.S.3
  • 55
    • 0034950612 scopus 로고    scopus 로고
    • Long-term and therapeutic-level hepatic gene expression of human factor IX after naked plasmid transfer in vivo
    • Miao CH, Thompson AR, Loeb K, et al. Long-term and therapeutic-level hepatic gene expression of human factor IX after naked plasmid transfer in vivo. Mol Ther. 2001;3: 947-957.
    • (2001) Mol Ther , vol.3 , pp. 947-957
    • Miao, C.H.1    Thompson, A.R.2    Loeb, K.3
  • 56
    • 0023883716 scopus 로고
    • A simple technique for the rescue of early region i mutations into infectious human adenovirus type 5
    • McGrory WJ, Bautista DS, Graham FL. A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5. Virology. 1988;163:614-617.
    • (1988) Virology , vol.163 , pp. 614-617
    • McGrory, W.J.1    Bautista, D.S.2    Graham, F.L.3
  • 57
    • 0029836780 scopus 로고    scopus 로고
    • Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy
    • Mittereder N, March KL, Trapnell BC. Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy. J Virol. 1996;70:7498-7509.
    • (1996) J Virol , vol.70 , pp. 7498-7509
    • Mittereder, N.1    March, K.L.2    Trapnell, B.C.3
  • 58
    • 31644432589 scopus 로고    scopus 로고
    • Regulatory T cells in immune surveillance and treatment of cancer
    • Yamaguchi T, Sakaguchi S. Regulatory T cells in immune surveillance and treatment of cancer. Semin Cancer Biol. 2006; 16:115-123.
    • (2006) Semin Cancer Biol , vol.16 , pp. 115-123
    • Yamaguchi, T.1    Sakaguchi, S.2
  • 60
    • 34247634525 scopus 로고    scopus 로고
    • GITR-GITRL system, a novel player in shock and inflammation
    • Krausz LT, Bianchini R, Ronchetti S, et al. GITR-GITRL system, a novel player in shock and inflammation. Scientific World J. 2007;7:533-566.
    • (2007) Scientific World J , vol.7 , pp. 533-566
    • Krausz, L.T.1    Bianchini, R.2    Ronchetti, S.3
  • 61
    • 33646387978 scopus 로고    scopus 로고
    • Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL)
    • Hanabuchi S, Watanabe N, Wang YH, et al. Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). Blood. 2006;107:3617-3623.
    • (2006) Blood , vol.107 , pp. 3617-3623
    • Hanabuchi, S.1    Watanabe, N.2    Wang, Y.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.