CTLA-4-mediated inhibition of early events of T cell proliferation

Journal of Immunology

Volumn 162, Issue 10, 1999, Pages 5813-5820

  Brunner, Monika C ^a,c   Chambers, Cynthia A ^a   Chan, Francis Ka Ming ^a   Hanke, Jeff ^b   Winoto, Astar ^a   Allison, James P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b PFIZER INC   (United States)

^c DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CYCLIN D3; CYCLIN DEPENDENT KINASE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CROSS LINKING; CYTOKINE PRODUCTION; HELPER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD3; ANTIGENS, DIFFERENTIATION; BIOLOGICAL TRANSPORT; CD4-POSITIVE T-LYMPHOCYTES; CELL CYCLE; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA-BINDING PROTEINS; GENES, REPORTER; HUMANS; IMMUNOCONJUGATES; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; S-PHASE KINASE-ASSOCIATED PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

EID: 0033563271     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (71)

1. van der Merwe, P. A., D. L. Bodian, S. Daenke, P. Linsley, and S. J. Davis. 1997. CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. J. Exp. Med. 185:393.
2. Linsley, P. S., S. G. Nadler, J. Bajoirath, R. Peach, H. T. Leung, J. Rogers, J. Bradshaw, M. Stebbins, G. Leytze, W. Brady, et al. 1995. Binding stoichiometry of the cytotoxic T lymphocyte-associated molecule-4 (CTLA-4): a disulfide-linked homodimer binds two CD86 molecules. J. Biol. Chem. 270:15417.
3. Linsley, P. S., J. Bradshaw, J. Greene, R. Peach. K. L. Bennett, and R. S. Mittler. 1996. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 4:535.
4. Leung, H. T., J. Bradshaw, J. S. Cleaveland, and P. S. Linsley. 1995. Cytotoxic T lymphocyte-associated molecule-4, a high avidity receptor for CD80 and CD86. contains an intracellular localization motif in its cytoplasmic tail. J. Biol. Chem. 270:1.
5. Wu, Y., Y. Guo, A. Huang, P. Zheng, and Y. Liu. 1997. CTLA-4-B7 interaction is sufficient to costimulate T cell clonal expansion. J. Exp. Med. 185:1.
6. Zheng, P., Y. Wu, Y. Guo, C. Lee, and Y. Liu. 1998. B7-CTLA-4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge. Proc. Natl. Acad. Sci. USA 95:6284.
7. Walunas, T. L., D. J. Lenschow, C. Y. Bakker, P. S. Linsley, G. J. Freeman, J. M. Green, C. B. Thompson, and J. A. Bluestone. 1994. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1:405.
8. Krummel, M. F., and J. P. Allison. 1995. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182:459.
9. + T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J. Immunol. 155:1032.
10. Krummel, M. F., T. J. Sullivan, and J. P. Allison. 1996. Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo. InI. Immunol. 8:519.
11. Leach, D. R., M. F. Krummel, and J. P. Allison. 1996. Enhancement of antitumor immunity by CTLA-4 blockade. Science 271:1734.
12. Kwon, E. D., A. A. Hurwitz, B. A. Foster, C. Madias, A. L. Feldhaus, N. M. Greenberg, M. B. Burg, and J. P. Allison. 1997. Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer. Proc. Natl. Acad. Sci. USA 94:8099.
13. McCoy, K., M. Camberis, and G. Le Gros. 1997. Protective immunity to nematode infection is induced by CTLA-4 blockade. J. Exp. Med. 186:183.
14. Chambers, C. A., and J. P. Allison. 1997. Co-stimulation in T cell responses. Curr. Opin. Immunol. 9:396.
15. Lühder, F., P. Höglund, J. P. Allison, C. Benoist, and D. Mathis. 1998. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J. Exp. Med. 187:427.
16. Walunas, T. L., A. I. Sperling, R. Khattri, C. B. Thompson, and J. A. Bluestone. 1996. CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance. J. Immunol. 156:1006.
17. Krummel, M. F., and J. P. Allison. 1996. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. 183:2533.
18. L induction. J. Immunol. 160:12.
19. Green, J. M., P. J. Noel, A. I. Sperling, T. L. Walunas, G. S. Gray, J. A. Bluestone, and C. B. Thompson. 1994. Absence of B7-dependent responses in CD28-deficient mice. Immunity 1:501.
20. Saito, K., J. Sakurai, J. Ohata, T. Kohsaka, H. Hashimoto, K. Okumura, R. Abe, and M. Azuma. 1998. Involvement of CD40 ligand-CD40 and CTLA-4/B7 pathways in murine acute graft-versus-host disease induced by allogeneic T cells lacking CD28. J. Immunol. 160:4225.
21. Lin, H., J. C. Rathmell, G. S. Gray, C. B. Thompson, J. M. Leiden, and M.-L. Alegre. 1998. Cytotoxic T lymphocyte antigen 4 (CTLA-4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA-4 can function independently of CD28. J. Exp. Med. 188:199.
22. Fallarino, F., P. E. Fields, and T. F. Gajewski. 1998. B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28. J. Exp. Med. 188:205.
23. Waterhouse, P., J. M. Penninger, E. Timms, A. Wakeham, A Shahinian, K. P. Lee, C. B. Thompson, H. Griesser, and T. W. Mak. 1995. CTLA-4 deficiency causes lymphoproliferalive disorder with early lethality. Science 270:985.
24. Tivol, E. A., F. Borriello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone, and A. H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role for CTLA-4. Immunity 3:541.
25. Chambers, C. A., D. Cado, T. Truong, and J. P. Allison. 1997. Thymocyte differentiation is normal in the CTLA-4-deficient mice. Proc. Natl. Acad. Sci. USA 94:9296.
26. Waterhouse, P., M. E. Bachmann, J. M. Penninger, P. S. Ohashi, and T. W. Mak. 1997. Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice. Eur. J. Immunol. 27: 1887.
27. + T cells. Immunity 7:885.
28. Tivol, E., S. D. Boyd, S. McKeon, F. Borriello, P. Nickerson, T. B. Strom, and A. Sharpe. 1997. CTLA-4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice. J. Immunol. 158:5091.
29. Freeman, G. J., D. B. Lombard, C. D. Gimmi, S. A. Brod, K. Lee, J. C. Laning, D. A. Hafler, M. E. Dorf, G. S. Gray, H. Reiser, et al. 1992. CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation: evidence of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production. J. Immunol. 149:3795.
30. Lindsten, T., K. P. Lee, E. S. Harris, B. Petryniak, N. Craighead, P. J. Reynolds, D. B. Lombard, G. J. Freeman, L. M. Nadler, G. S. Gray, C. B. Thompson, and C. H. June. 1993. Characterization of CTLA-4 structure and expression on human T cells. J. Immunol. 151:3489.
31. Linsley, P. S., J. L. Greene, P. Tan, J. Bradshaw, J. A. Ledbetter, C. Anasetti, and N. K. Damle. 1992. Coexpression and functional cooperativity of CTLA-4 and CD28 on activated T lymphocytes. J. Exp. Med. 176:1595.
32. Perkins, D., Z. Wang, C. Donovan, H. He, D. Mark, G. Guan, Y. Wang, T. Walunas, J. Bluestone, and J. E. A. Listman. 1996. Regulation of CTLA-4 expression during T cell activation. J. Immunol. 156:4154.
33. Alegre, M.-L., P. J. Noel, B. J. Eisfelder, E. Chuang, M. R. Clark, S. L. Reiner, and C. B. Thompson. 1996. Regulation of surface and intracellular expression of CTLA-4 on mouse T cells. J. Immunol. 157:4762.
34. Jenkins, M. K. 1994. The ups and downs of costimulation. Immunity 1:443.
35. Gribben, J. G., G. J. Freeman, V. A. Boussiotis, P. Rennert, C. J. Jellis, E. Greenfield, M. Barber, V. A. Restivo, X. Ke, G. S. Gray, and L. M. Nadler. 1995. CTLA-4 mediates antigen-specific apoptosis of human T cells. Proc. Natl. Acad. Sci. USA 92:811.
36. Linsley, P. S., and J. A. Ledbetter. 1993. The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11:191.
37. Lindsten, T., C. H. June, J. A. Ledbetter, G. Stella, and C. B. Thompson. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244:339.
38. Umlauf, S. W., B. Beverly, O. Lantz, and R. H. Schwartz. 1995. Regulation of interleukin 2 gene expression by CD28 costimulation in mouse T-cell clones: both nuclear and cytoplasmic RNAs are regulated with complex kinetics. Mol. Cell. Biol. 15:3197.
39. Brorson, K. A., B. Beverley, S. M. Kang, M. Lenardo, and R. H. Schwartz. 1991. Transcriptional regulation of cytokine genes in nontransformed T cells: apparent constitutive signals in run-on assays can be caused by repeat sequences. J. Immunol. 147:3601.
40. Rooney, J. W., T. Hoey, and L. H. Glimcher. 1995. Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene. Immunity 2:473.
41. Sherr, C. J., and J. M. Roberts. 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9:1149.
42. Chaffin, K. E., C. R. Beals, T. M. Wilkie, K. A. Forbush, M. I. Simon, and R. M. Perlmutter. 1990. Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase. EMBO J. 9:3821.
43. Novak, T. J., P. M. White, and E. V. Rothenberg. 1990. Regulatory anatomy of the murine interleukin-2 gene. Nucleic Acids Res. 18:4523.
44. Cockerill, P. N., and W. T. Garrard. 1986. Chromosomal loop anchorage of the κ immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II. Cell 44:273.
45. Allison, J. P., W. L. Havran, M. Poenie, J. Kimura, L. Degraffenreid, S. Ajami, G. Duwe, A. Weiss, and R. Tsien. 1987. Expression and function of CD3 on murine thymocytes. In The T Cell Receptor, UCLA Symposia on Molecular and Cellular Biology, New Series. J. Kappler, and M. Davis, eds. Alan R. Liss, New York, p. 33.
46. Gross, J. A., E. Callas, and J. P. Allison. 1992. Identification and distribution of the costimulatory receptor CD28 in the mouse. J. Immunol. 149:380.
47. + dendritic epidermal cells revealed by Vγ3-specific monoclonal antibody. Proc. Natl. Acad. Sci. USA 86: 4185.
48. Ozato, K., and D. H. Sachs. 1981. Monoclonal antibodies to mouse MHC antigens. J. Immunol. 126:317.
49. Symington, F., and J. Sprent. 1981. A monoclonal antibody detecting an Ia specificity mapping in the I-A or I-E subregion. Immunogenetics 14:53.
50. Sarmiento, M., S. Glasebrook, and F. W. Fitch. 1980. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt2 antigen block T cell-mediated cytolysis in the absence of complement. J. Immunol. 125:2665.
51. Murray, L. J., R. Lee, and C. Martens. 1990. In vivo cytokine gene expression in T cells of the autoimmune MRL/mp-lpr/lpr mouse. Eur. J. Immunol. 20:163.
52. Platzer, C., G. Richter, K. Uberla, W. Muller, H. Blocker, T. Diamantstein, and T. Blankenstein. 1992. Analysis of cytokine mRNA levels in interleukin-4 transgenic mice by quantitative polymerase chain reaction. Eur. J. Immunol. 22:1179.
53. b allele on the response to allo-HPPD. Eur. J. Immunol. 25:3285.
54. Woronicz, J. D., A. Lina, B. J. Calnan, S. Szychowski, L. Cheng, and A. Winoto. 1995. Regulation of the Nur77 orphan receptor in activation-induced apoptosis. Mol. Cell. Biol. 15:6364.
55. ink4. Mol. Cell. Biol. 15:2682.
56. Lucas, J. J., A. Szepesi, J. F. Modiano, J. Domenico, and E. W. Gelfand. 1995. Regulation of synthesis and activity of the PLSTIRE protein (cyclin-dependent kinase 6 (cdk6), a major cyclin D-associated cdk4 homologue in normal human T lymphocytes. J. Immunol. 154:6275.
57. Lucas, J. J., A. Szepesi, J. Domenico, A. Tordai, N. Terada, and E. W. Gelfand. 1995. Differential regulation of the synthesis and activity of the major cyclin-dependent kinases, p34cdc2, p33cdk2, p34cdk4, during cell cycle entry and progression in normal human T lymphocytes. J. Cell. Physiol. 165:406.
58. Jain, J., C. Loh, and A. Rao. 1995. Transcriptional regulation of the IL-2 gene. Curr. Biol. 7:333.
59. Northrop, L. P., S. N. Ho, L. Chen, D. J. Thomas, L. A. Timmerman, G. P. Nolan, A. Admon, and G. R. Crabtree, 1994. NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 369:497.
60. Firpo, E. J., A. Koff, M. J. Solomon, and J. M. Roberts. 1994. Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes. Mol. Cell Biol. 14:4889.
61. Nourse, J., E. Firpo, W. M. Flanagan, S. Coats, K. Polyak, M. H. Lee, J. Massague, G. R. Crabtree, and J. M. Roberts. 1994. Interleukin 2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570.
62. Meyerson, M., and E. Harlow. 1994. Identification of Gl kinase activity for cdk6, a novel cyclin D partner. Mol. Cell. Biol. 14:2077.
63. Modiano, J. F., J. Domenico, A. Szepesi, N. Terada, J. J. Lucas, and E. W. Gelfand. 1995. Symmetry of the activation of cyclin-dependent kinases in mitogen and growth factor-stimulated T lymphocytes. Ann. NY Acad. Sci. 766:134.
64. Modiano, J. F., J. Domenicao, A. Szepeso, J. J. Lucas, and E. W. Gelfand. 1994. Differential requirements for interleukin-2 distinguish the expression and activity of the cyclin-dependent kinases cdk4 and cdk2 in human T cells. J. Biol. Chem. 269:2972.
65. 2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor ζ and ZAP70. J. Exp. Med. 186:1645.
66. Bachmann, M. F., P. Waterhouse, D. E. Speiser, McKall-Faienza, T. W. Mak, and P. S. Ohashi. 1998. Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells. J. Immunol. 160:95.
67. + T cells. Eur. J. Immunol. 28:3137.
68. Walunas, T. L., C. Y. Bakker, and J. A. Bluestone. 1996. CTLA-4-ligation blocks CD28-dependent T cell activation. J. Exp. Med. 183:2541.
69. Shapiro, V. S., K. E. Truitt, J. B. Imboden, and A. Weiss. 1997. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites. Mol. Cell. Biol. 17:4051.
70. Su, B. E., M. Jacinto, T. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77:727.
71. Tusto, L., and O. Acuto. 1998. CD28 affects the earliest signaling events generated by TCR engagement. Eur. J. Immunol. 28:2131.