A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in Th cells and regulates their responses

International Immunology

Volumn 14, Issue 6, 2002, Pages 555-566

  Arimura, Yutaka ^a   Kato, Hidehito ^a   Dianzani, Umberto ^b   Okamoto, Toshihiro ^a   Kamekura, Soichiro ^a   Buonfiglio, Donatella ^b   Miyoshi Akiyama, Tohru ^a   Uchiyama, Takehiko ^a   Yagi, Junji ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

Immunoregulation; Inducible co stimulator; Signal transduction; Th2 cells

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; GAMMA INTERFERON; INDUCIBLE COSTIMULATOR; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; LYMPHOKINE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; INDUCIBLE T CELL CO STIMULATOR; INDUCIBLE T-CELL CO-STIMULATOR; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; T LYMPHOCYTE ANTIGEN;

ANIMAL CELL; ARTICLE; CELL POLARITY; CELLULAR IMMUNITY; CONTROLLED STUDY; CROSS LINKING; CYTOKINE PRODUCTION; ENZYME ACTIVATION; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; COMPARATIVE STUDY; CYTOLOGY; FEMALE; HELPER CELL; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; SPECIES DIFFERENCE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; FEMALE; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; T-LYMPHOCYTES, HELPER-INDUCER; TH1 CELLS; TH2 CELLS;

EID: 0035988233     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxf022     Document Type: Article

References (45)

1. CD28 delivers a co-stimulatory signal involved in antigen-specific IL-2 production by human T cells
2. CD28-mediated signaling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
3. Signals and signs for lymphocyte response
4. CD28/B7 system of T cell co-stimulation
5. CTLA-4 can function as a negative regulator of T cell activation
6. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
7. Co-stimulation in T cell responses
8. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
9. T-cell co-stimulation through B7RP-1 and ICOS
10. B7h, a novel costimulatory homolog of B7.1 and B7.2 is induced by TNF
11. Characterization of human inducible co-stimulator ligand expression and function
12. Inducible co-stimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection
13. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses
14. + T cells
15. ICOS co-stimulatory receptor is essential for T-cell activation and function
16. ICOS is critical for CD40-mediated antibody class switching
17. ICOS is essential for effective T-helper-cell responses
18. ICOS co-stimulation requires IL-2 and can be prevented by CTLA-4 engagement
19. Characterization of H4: A murine T lymphocyte activation molecule functionally associated with the CD3/TCR
20. Characterization of a novel human surface molecule selectively expressed by mature thymocytes, activated T cells and subsets of T cell lymphomas
21. The T cell activation molecule H4 and the CD28-like molecule ICOS are identical
22. + T cells and responsiveness to a superantigen, Yersinia pseudotuberculosis-derived mitogen
23. ras
24. DNA sequencing of the gene encoding a bacterial superantigen, Yersinia pseudotuberculosis-derived mitogen (YPM), and characterization of the gene product, cloned YPM
25. Identification of murine T cells reactive with the bacterial superantigen Yersinia pseudotuberculosis-derived mitogen (YPM) and factors involved in YPM-induced toxicity in mice
26. + T cells
27. β domain of the T cell antigen receptor
28. Superantigenic properties of a novel mitogenic substance produced by Yersinia pseudotuberculosis isolated from patients manifesting acute and systemic symptoms
29. Mechanism of activation of protein kinase B by insulin and IGF-1
30. Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation
31. h2 cytokine gene expression in CD4 T cells
32. JNK is involved in signal integration during co-stimulation of T lymphocytes
33. JNK is required for effector T-cell function but not for T-cell activation
34. Binding of phosphatidyl-3-OH kinase to CD28 is required for T cell signaling
35. A negative role for phosphoinositide 3-kinase in T-cell antigen receptor function
36. Novel role of PI3-K in CD28-mediated co-stimulation
37. H2 cytokines
38. A novel functional interaction between Vav and PKCχ is required for TCR-induced T cell activation
39. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
40. The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A
41. h1 cells requires MAP kinase JNK2
42. Defective T cell differentiation in the absence of Jnk1
43. Expression of the novel T cell activation molecule hpH4 in HIV-infected patients: Correlation with disease status
44. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
45. + stage during positive selection and promotes thymocyte differentiation at several control points