Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy

Cancer Immunology, Immunotherapy

Volumn 59, Issue 9, 2010, Pages 1367-1377

  Coe, David ^a   Begom, Shaima ^a   Addey, Caroline ^a   White, Matthew ^a   Dyson, Julian ^a   Chai, Jian Guo ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Anti GITR; Depletion; HY; Regulatory T cells; Therapy; Tumour

Indexed keywords

GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; MONOCLONAL ANTIBODY DTA 1; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER IMMUNOTHERAPY; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG SELECTIVITY; FEMALE; LYMPH NODE; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SINGLE DRUG DOSE; T CELL DEPLETION; TUMOR;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; CELL LINE, TUMOR; FORKHEAD TRANSCRIPTION FACTORS; GENE KNOCK-IN TECHNIQUES; IMMUNOTHERAPY; LYMPHOCYTE DEPLETION; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; NEOPLASM TRANSPLANTATION; RATS; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; T-LYMPHOCYTES, REGULATORY; URINARY BLADDER NEOPLASMS;

EID: 77955515915     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-010-0866-5     Document Type: Article

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