Expression and regulation of the PD-L1 immunoinhibitory molecule on micro vascular endothelial cells

Microcirculation

Volumn 9, Issue 2, 2002, Pages 133-145

  Eppihimer, Michael J ^a   Gunn, Jason ^a   Freeman, Gordon J ^a   Greenfield, Edward A ^b   Chernova, Tetyana ^b   Erickson, Jamie ^a   Leonard, John P ^a  

^a PFIZER INC   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Cellular activation; Costimulation; Endothelial cell; T lymphocyte

Indexed keywords

MURINAE;

B7 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; MEMBRANE PROTEIN; MESSENGER RNA; PDCD1LG1 PROTEIN, MOUSE; PEPTIDE; PLASMA PROTEIN; RECOMBINANT GAMMA INTERFERON;

ANIMAL; ARTICLE; C57BL MOUSE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; MALE; METABOLISM; MICROCIRCULATION; MOUSE; MOUSE MUTANT; T LYMPHOCYTE; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIGENS, CD80; BLOOD PROTEINS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; INTERFERON TYPE II; INTERFERON-GAMMA, RECOMBINANT; INTERLEUKIN-12; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROCIRCULATION; PEPTIDES; RNA, MESSENGER; T-LYMPHOCYTES;

EID: 0036549835     PISSN: 10739688     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mn.7800123     Document Type: Article

References (36)

1. 1 Arbiser JL, Moses MA, Fernandez CA, Ghiso N., Cao Y., Klauber N., et al. (1997). Oncogenic H‐ras stimulates tumor angiogenesis by two distinct pathways. Proc Natl Acad Sci USA 94: 861–866.
2. 2 Billiau A., Heremans H., Vandekerckhove F., Dijkmans R., Sobis H., Meulepas E., Carton H.. (1988). Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN‐gamma. J Immunol 140: 1506–1510.
3. 3 Briscoe DM, Henault LE, Geehan C., Alexander S., Lichtman AH. (1997). Human endothelial cell co‐stimulation of T cell IFN‐gamma production. J Immunol 159: 3247–3256.
4. 4 Dalton DK, Pitts‐Meek S., Keshav S., Figari IS, Bradley A., Stewart TA. (1993). Multiple defects of immune cell function in mice with disrupted interferon‐g genes. Science 259: 1739–1742.
5. 5 Duong TT, St. Louis J., Gilbert JJ, Finkelman FD, Strejan GH. (1992). Effect of anti‐interferon‐gamma and anti‐interleukin‐2 monoclonal antibody treatment on the development of actively and passively induced experimental allergic encephalomyelitis in the SJL/J mouse. J Neuroimmunol 36: 105–115.
6. 6 Epperson DE, Pober JS. (1994). Antigen‐presenting function of human endothelial cells: direct activation of resting CD8 T cells. J Immunol 153: 5402–5412.
7. 7 Eppihimer MJ, Granger DN. (1999). In vivo measurements of endothelial cell adhesion molecule expression. Methods Enzymol 301: 14–22.
8. 8 Eppihimer MJ, Russell J., Anderson DC, Wolitzky BA, Granger, DN. (1997). Endothelial cell adhesion molecule expression in gene‐targeted mice. Am J Physiol 273: H1903–H1908.
9. 9 Eppihimer MJ, Russell J., Langley R., Vallien G., Anderson DC, Granger DN. (1998). Differential expression of platelet‐endothelial cell adhesion molecule‐1 (PECAM‐1) in murine tissues. Microcirculation 5: 179–188.
10. 10 Eppihimer MJ, Wolitzky B., Anderson DC, Labow MA, Granger DN. (1996). Heterogeneity of E‐ and P‐selectins in vivo. Circ Res 79: 560–569.
11. 11 Freeman GJ, Long AJ, Iwai Y., Bourque K., Chernova T., Nishimura H., et al. (2000). Engagement of the PD‐1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 192: 1027–1034.
12. 12 Gately MK, Warrier RR, Honasoge S., Carvajal DM, Faherty DA, Connaughton SE, et al. (1994). Administration of recombinant IL‐12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN‐gamma in vivo. Int Immunol 6: 157–167.
13. 13 Hancock WW, Sayegh MH, Zheng XG, Peach R., Linsley PS, Turka LA. (1996). Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc Natl Acad Sci USA 93: 13967–13972.
14. 14 Henninger DW, Panes J., Eppihimer MJ, Russell J., Gerritsen M., Anderson DC, et al. (1997). Cytokine‐induced VCAM‐1 and ICAM‐1 expression in different organs of the mouse. J Immunol 158: 1825–1832.
15. 15 Heremans H., Dillen C., Groenen M., Martens E., Billiau A.. (1996). Chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice: enhancement by monoclonal antibodies against interferon‐gamma. Eur J Immunol 26: 2393–2398.
16. 16 Jollow KC, Zimring JC, Sundstrom JB, Ansari AA. (1999). CD40 ligation induced phenotypic and functional expression of CD80 by human cardiac microvascular endothelial cells. Transplantation 68: 430–439.
17. 17 Karmann K., Hughes CC, Schechner J., Fanslow WC, Pober JS. (1995). CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression. Proc Natl Acad Sci USA 92: 4342–4346.
18. 18 Kawashima H., Gregerson DS. (1994). Corneal endothelial cells block T cell proliferation, but not T cell activation or responsiveness to exogenous IL‐2. Curr Eye Res 13: 575–585.
19. 19 Kawashima H., Prasad SA, Gregerson DS. (1994). Corneal endothelial cells inhibit T cell proliferation by blocking IL‐2 production. J Immunol 153: 1982–1989.
20. 20 Knolle PA, Schmitt E., Jin S., Germann T., Duchmann R., Hegenbarth S., et al. (1999). Induction of cytokine production in naive CD4 (+) T cells by antigen‐presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells. Gastroenterology 116: 1428–1440.
21. 21 Krakowski M., Owens T.. (1996). Interferon‐gamma confers resistance to experimental allergic encephalomyelitis. Eur J Immunol 26: 1641–1646.
22. 22 Latchman Y., Wood CR, Chernova T., Chaudhary D., Borde M., Chernova I., et al. (2001). PD‐L2 is a second ligand for PD‐I and inhibits T cell activation. Nat Immunol 2: 261–268.
23. 23 Limmer A., Ohl J., Kurts C., Ljunggren HG, Reiss Y., Groettrup M., et al. (2000). Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen‐specific T‐cell tolerance. Nat Med 6: 1348–1354.
24. 24 Ma W., Pober JS. (1998). Human endothelial cells effectively costimulate cytokine production by, but not differentiation of, naive CD4+ T cells. J Immunol 161: 2158–2167.
25. 25 Marelli‐Berg FM, Frasca L., Weng L., Lombardi G., Lechler RI. (1999). Antigen recognition influences transendothelial migration of CD4+ T cells. J Immunol 162: 696–703.
26. 26 Marelli‐Berg FM, Hargreaves RE, Carmichael P., Dorling A., Lombardi G., Lechler RI. (1996). Major histocompatibility complex class II‐expressing endothelial cells induce allospecific nonresponsiveness in naive T cells. J Exp Med 183: 1603–1612.
27. 27 Marelli‐Berg FM, Scott D., Bartok I., Peek E., Dyson J., Lechler RI. (2000). Activated murine endothelial cells have reduced immunogenicity for CD8+ T cells: a mechanism of immunoregulation? J Immunol 165: 4182–4189.
28. 28 Murray AG, Libby P., Pober JS. (1995). Human vascular smooth muscle cells poorly co‐stimulate and actively inhibit allogeneic CD4+ T cell proliferation in vitro. J Immunol 54: 151–161.
29. 29 Nishimura H., Nose M., Hiai H., Minato N., Honjo T.. (1999). Development of lupus‐like autoimmune diseases by disruption of the PD‐1 gene encoding an ITIM motif‐carrying immunoreceptor. Immunity 11: 141–151.
30. 30 Panes J., Perry MA, Anderson DC, Manning A., Leone B., Cepinskas G., et al. (1995). Regional differences in constitutive and induced ICAM‐1 expression in vivo. Am J Physiol 269: H1955–H1964.
31. 31 Platanias LC, Fish EN. (1999). Signaling pathways activated by interferons. Exp Hematol 27: 1583–1592.
32. 32 Savage CO, Hughes CC, Pepinsky RB, Wallner BP, Freedman AS, Pober JS. (1991). Endothelial cell lymphocyte function‐associated antigen‐3 and an unidentified ligand act in concert to provide costimulation to human peripheral blood CD4+ T cells. Cell Immunol 137: 150–163.
33. 33 Springer TA, Lasky LA. (1991). Sticky sugars for selecting Nature 349: 196–197.
34. 34 Tallarida RJ, Murray RB. (1987). Manual of Pharmacologic Calculations with Computer Programs. Springer‐Verlag. New York, pp. 1–297.
35. 35 Vermeire K., Heremans H., Vandeputte M., Huang S., Billiau A., Matthys P.. (1997). Accelerated collagen‐induced arthritis in IFN‐gamma receptor‐deficient mice. J Immunol 158: 5507–5513.
36. 36 Williams RO, Williams DG, Feldmann M., Maini RN. (1993). Increased limb involvement in murine collagen‐induced arthritis following treatment with anti‐interferon‐gamma. Clin Exp Immunol 192: 323–327.