Cutting edge: Selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT

Journal of Immunology

Volumn 168, Issue 10, 2002, Pages 4832-4835

  Tamada, Koji ^a   Ni, Jian ^a   Zhu, Gefeng ^a   Fiscella, Michele ^a   Teng, Baiqin ^a   Van Deursen, Jan M A ^a   Chen, Lieping ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; PROTEIN LIGHT; STAPHYLOCOCCUS ENTEROTOXIN A; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; CELLULAR IMMUNITY; IMMUNOSTIMULATION; KNOCKOUT MOUSE; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; LYMPHOID ORGAN; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; T LYMPHOCYTE;

EID: 0037094087     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.10.4832     Document Type: Article

References (22)

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3. LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response
4. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis
5. LIGHT, a novel ligand for lymphotoxin β receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer
6. The lymphotoxin-β receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells
7. Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway
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12. The TNF superfamily members LIGHT and CD154 (CD40 ligand) costimulate induction of dendritic cell maturation and elicit specific CTL activity
13. The lymphotoxin β receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues
14. Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice
15. Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity
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