Structural and functional analysis of the costimulatory receptor programmed death-1

Immunity

Volumn 20, Issue 3, 2004, Pages 337-347

  Zhang, Xuewu ^a,d   Schwartz, Jean Claude D ^a,e   Guo, Xiaoling ^a   Bhatia, Sumeena ^a   Cao, Erhu ^a   Chen, Lieping ^b   Zhang, Zhong Yin ^a   Edidin, Michael A ^c   Nathenson, Stanley G ^a   Almo, Steven C ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e EMORY UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; PROGRAMMED DEATH 1 RECEPTOR; RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL SURFACE; CRYSTAL STRUCTURE; IMMUNOGLOBULIN VARIABLE REGION; LIGAND BINDING; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; RECEPTOR BINDING; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION; BLOOD PROTEINS; IMMUNOGLOBULIN VARIABLE REGION; LIGANDS; MEMBRANE GLYCOPROTEINS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDES; RECEPTORS, IMMUNOLOGIC; SEQUENCE ALIGNMENT;

EID: 12144290320     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(04)00051-2     Document Type: Article

References (37)

1. Agata Y., Kawasaki A., Nishimura H., Ishida Y., Tsubata T., Yagita H., Honjo T. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 8:1996;765-772.
2. Bogan A.A., Thorn K.S. Anatomy of hot spots in protein interfaces. J. Mol. Biol. 280:1998;1-9.
3. Brunger A.T., Adams P.D., Clore G.M., DeLano W.L., Gros P., Grosse-Kunstleve R.W., Jiang J.S., Kuszewski J., Nilges M., Pannu N.S.et al. Crystallography and NMR system. a new software suite for macromolecular structure determination Acta Crystallogr. D Biol. Crystallogr. 54:1998;905-921.
4. Carreno B.M., Collins M. The B7 family of ligands and its receptors. new pathways for costimulation and inhibition of immune responses Annu. Rev. Immunol. 20:2002;29-53.
5. Collins A.V., Brodie D.W., Gilbert R.J., Iaboni A., Manso-Sancho R., Walse B., Stuart D.I., van der Merwe P.A., Davis S.J. The interaction properties of costimulatory molecules revisited. Immunity. 17:2002;201-210.
6. Davis S.J., Ikemizu S., Wild M.K., van der Merwe P.A. CD2 and the nature of protein interactions mediating cell-cell recognition. Immunol. Rev. 163:1998;217-236.
7. Dong H., Zhu G., Tamada K., Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 5:1999;1365-1369.
8. Dong H., Strome S.E., Salomao D.R., Tamura H., Hirano F., Flies D.B., Roche P.C., Lu J., Zhu G., Tamada K.et al. Tumor-associated B7-H1 promotes T-cell apoptosis. a potential mechanism of immune evasion Nat. Med. 8:2002;793-800.
9. Evans S.V. Setor. hardware-lighted three-dimensional solid model representations of macromolecules J Mol Graph. 11:1993;134-138.
10. Finger L.R., Pu J., Wasserman R., Vibhakar R., Louie E., Hardy R.R., Burrows P.D., Billips L.G. The human PD-1 gene. complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors Gene. 197:1997;177-187.
11. Freeman G.J., Long A.J., Iwai Y., Bourque K., Chernova T., Nishimura H., Fitz L.J., Malenkovich N., Okazaki T., Byrne M.C.et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192:2000;1027-1034.
12. Gouet P., Courcelle E., Stuart D.I., Metoz F. ESPript. analysis of multiple sequence alignments in PostScript Bioinformatics. 15:1999;305-308.
13. Iwai Y., Ishida M., Tanaka Y., Okazaki T., Honjo T., Minato N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl. Acad. Sci. USA. 99:2002;12293-12297.
14. Jones T.A., Zou J.Y., Cowan S.W., Kjeldgaard M. Improved methods for binding protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A. 47:1991;110-119.
15. Kenworthy A.K., Edidin M. Distribution of a glycosylphosphatidylinositol- anchored protein at the apical surface of MDCK cells examined at a resolution of <100 A using imaging fluorescence resonance energy transfer. J. Cell Biol. 142:1998;69-84.
16. Kissinger C.R., Gehlhaar D.K., Fogel D.B. Rapid automated molecular replacement by evolutionary search. Acta Crystallogr. D Biol. Crystallogr. 55:1999;484-491.
17. Latchman Y., Wood C.R., Chernova T., Chaudhary D., Borde M., Chernova I., Iwai Y., Long A.J., Brown J.A., Nunes R.et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 2:2001;261-268.
18. Metzler W.J., Bajorath J., Fenderson W., Shaw S.Y., Constantine K.L., Naemura J., Leytze G., Peach R.J., Lavoie T.B., Mueller L.et al. Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28. Nat. Struct. Biol. 4:1997;527-531.
19. Morton P.A., Fu X.T., Stewart J.A., Giacoletto K.S., White S.L., Leysath C.E., Evans R.J., Shieh J.J., Karr R.W. Differential effects of CTLA-4 substitutions on the binding of human CD80 (B7-1) and CD86 (B7-2). J. Immunol. 156:1996;1047-1054.
20. Nicholls A., Sharp K.A., Honig B. Protein folding and association. insights from the interfacial and thermodynamic properties of hydrocarbons Proteins. 11:1991;281-296.
21. Nishimura H., Nose M., Hiai H., Minato N., Honjo T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity. 11:1999;141-151.
22. Nishimura H., Okazaki T., Tanaka Y., Nakatani K., Hara M., Matsumori A., Sasayama S., Mizoguchi A., Hiai H., Minato N.et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science. 291:2001;319-322.
23. Okazaki T., Maeda A., Nishimura H., Kurosaki T., Honjo T. PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Proc. Natl. Acad. Sci. USA. 98:2001;13866-13871.
24. Ostrov D.A., Shi W., Schwartz J.C., Almo S.C., Nathenson S.G. Structure of murine CTLA-4 and its role in modulating T cell responsiveness. Science. 290:2000;816-819.
25. Otwinowski Z., Minor W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276:1997;307-326.
26. Pentcheva T., Edidin M. Clustering of peptide-loaded MHC class I molecules for endoplasmic reticulum export imaged by fluorescence resonance energy transfer. J. Immunol. 166:2001;6625-6632.
27. Reyes-Moreno C., Girouard J., Lapointe R., Darveau A., Mourad W. CD40/CD40 homodimers are required for CD40-induced phosphatidylinositol-3 kinase-dependent expression of B7.2 by human B cells. J. Biol. Chem. 279:2003;7799-7806.
28. Schwartz J.C., Zhang X., Nathenson S.G., Almo S.C. Structural mechanisms of costimulation. Nat. Immunol. 3:2002;427-434.
29. Schwartz J.C., Zhang X., Fedorov A.A., Nathenson S.G., Almo S.C. Structural basis for co-stimulation by the human CTLA-4/B7-2 complex. Nature. 410:2001;604-608.
30. Sharpe A.H., Freeman G.J. The B7-CD28 superfamily. Nat. Rev. Immunol. 2:2002;116-126.
31. Stamper C.C., Zhang Y., Tobin J.F., Erbe D.V., Ikemizu S., Davis S.J., Stahl M.L., Seehra J., Somers W.S., Mosyak L. Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses. Nature. 410:2001;608-611.
32. Tseng S.Y., Otsuji M., Gorski K., Huang X., Slansky J.E., Pai S.I., Shalabi A., Shin T., Pardoll D.M., Tsuchiya H. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 193:2001;839-846.
33. Wang J., Springer T.A. Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses. Immunol. Rev. 163:1998;197-215.
34. Wang J.H., Smolyar A., Tan K., Liu J.H., Kim M., Sun Z.Y., Wagner G., Reinherz E.L. Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors. Cell. 97:1999;791-803.
35. Wang S., Zhu G., Tamada K., Chen L., Bajorath J. Ligand binding sites of inducible costimulator and high avidity mutants with improved function. J. Exp. Med. 195:2002;1033-1041.
36. Wang S., Bajorath J., Flies D.B., Dong H., Honjo T., Chen L. Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. J. Exp. Med. 197:2003;1083-1091.
37. Zhang X., Schwartz J.C., Almo S.C., Nathenson S.G. Expression, refolding, purification, molecular characterization, crystallization, and preliminary X-ray analysis of the receptor binding domain of human B7-2. Protein Expr. Purif. 25:2002;105-113.