Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus

Journal of Immunology

Volumn 163, Issue 9, 1999, Pages 4833-4841

  DeBenedette, Mark A ^a   Wen, Tao ^a   Bachmann, Martin F ^a,b   Ohashi, Pamela S ^a   Barber, Brian H ^a   Stocking, Kim L ^c   Peschon, Jacques J ^c   Watts, Tania H ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 2; LIGAND;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; GRAFT REJECTION; INFLUENZA VIRUS; LIGAND BINDING; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN ALLOGRAFT; VESICULAR STOMATITIS VIRUS; VIRUS INFECTION;

4-1BB LIGAND; ANIMALS; ANTIBODIES, VIRAL; ANTIGENS, CD28; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; GENE TARGETING; GRAFT REJECTION; INFLUENZA A VIRUS; LIGANDS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MICE; MICE, INBRED A; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; SKIN TRANSPLANTATION; T-LYMPHOCYTES, CYTOTOXIC; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; VESICULAR STOMATITIS-INDIANA VIRUS;

EID: 0032754036     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Lenschow, D. J., T. L. Walunas, and J. A. Bluestone. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233.
2. Shahinian, A., K. Pfeffer, K. P. Lee, T. M. Kundig, K. Kishihara, A. Wakeham, K. Kawai, P. S. Ohashi, C. B. Thompson, and T. W. Mak. 1993. Differential T cell costimulatory requirements in CD28-deficient mice. Science 261:609.
3. Kawai, K., A. Shahinian, T. W. Mak, and P. S. Ohashi. 1996. Skin allograft rejection in CD28-deficient mice. Transplantation 61:352.
4. Gause, W. C., S. J. Chen, R. J. Greenwald, M. J. Halvorson, P. Lu, X. D. Zhou, S. C. Morris, K. P. Lee, C. H. June, F. D. Finkelman, J. F. Urban, and R. Abe. 1997. CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response. J. Immunol. 158:4082.
5. Wen, T., K. Kono, A. Shahinian, R. Kiessling, T. W. Mak, and G. Klein. 1997. CD28 is not required for rejection of unmanipulated syngeneic and autologous tumors. Eur. J. Immunol. 27:1988.
6. Kundig, T. M., A. Shahinian, K. Kawai, H. W. Mittrucker, E. Sebzda, M. F. Bachmann, T. W. Mak, and P. S. Ohashi. 1996. Duration of TCR stimulation determines costimulatory requirement of T cells. Immunity 5:41.
7. Bachmann, M. F., R. M. Zinkernagel, and A. Oxenius. 1998. Immune responses in the absence of costimulation: viruses know the trick. J. Immunol. 161:5791.
8. Vinay, D. S., and B. S. Kwon. 1998. Role of 4-1BB in immune responses. Semin. Immunol. 10:481.
9. Melero, I., J. V. Johnston, W. W. Shufford, R. S. Mittler, and L. Chen. 1998. NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell. Immunol. 190:167.
10. - T lymphocytes by 4-1BB ligand. J. Immunol. 158:551.
11. - T cells. J. Immunol. 158:3081.
12. Saoulli, K., S. Y. Lee, J. L. Cannons, W. C. Yen, A. Santana, M. D. Goldstein, N. Bangia, M. A. DeBenedette, T. W. Mak, Y. Choi, and T. H. Watts. 1998. CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand. J. Exp. Med. 187:1849.
13. Hurtado, J. C., Y. J. Kim, and B. S. Kwon. 1997. Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death. J. Immunol. 158:2600.
14. Goodwin, R. G., W. S. Din, T. Davis-Smith, D. M. Anderson, S. D. Gimpel, T. A. Sato, C. R. Maliszewski, C. I. Brannan, N. G. Copeland, N. A. Jenkins, T. Farrah, R. J. Armitage, W. C. Fanslow, and C. A. Smith. 1993. Molecular cloning of a ligand for the inducible T cell gene 4-1BB : a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur. J. Immunol. 1993:2631.
15. Pollok, K. E., Y.-J. Kim, J. Hurtado, Z. Zhou, K. K. Kim, and B. S. Kwon. 1994. 4-1BB T cell antigen binds to mature B cells and macrophages, and costimulates anti-μ-primed splenic B cells. Eur. J. Immunol. 24:367.
16. DeBenedette, M. A., N. R. Chu, K. E. Pollok, J. Hurtado, W. F. Wade, B. S. Kwon, and T. H. Watts. 1995. Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP. J. Exp. Med. 181:985.
17. Kim, Y. J., S. H. Kim, P. Mantel, and B. S. Kwon. 1998. Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses. Eur. J. Immunol. 28:881.
18. + T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J. Exp. Med. 186:47.
19. Melero, I., W. W. Shuford, S. A. Newby, A. Aruffo, J. A. Ledbetter, K. E. Hellstr[umlaut]om, R. S. Mittler, and L. Chen. 1997. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat. Med. 3:682.
20. Melero, I., N. Bach, K. E. Hellstrom, A. Aruffo, R. S. Mittler, and L. Chen. 1998. Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway. Eur. J. Immunol. 28: 1116.
21. Guinn, B. A., M. A. DeBenedette, T. H. Watts, and N. L. Berinstein. 1999. 4-1BBL co-operates with B7-1 and B7-2 in converting a B cell lymphoma cell line into a long lasting anti-tumor vaccine. J. Immunol. 162:5003.
22. + splenic T cells after CD28 receptor ligation. J. Immunol. 154:985.
23. Liu, Y., R. H. Wenger, M. Zhao, and P. J. Nielsen. 1997. Distinct costimulatory molecules are required for the induction of effector and memory cytotoxic T lymphocytes. J. Exp. Med. 185:251.
24. Kim, K. J., C. Kanellopoulos-Langevin, R. M. Merwin, D. H. Sachs, and R. A. Asofsky. 1979. Establishment and characterization of BALB/c lymphoma lines with B cell properties. J Immunol. 122:549.
25. Pollok, K. E., Y.-J. Kim, Z. Zhou, J. Hurtado, K. K. Kim, R. T. Pickard, and B. S. Kwon. 1993. Inducible T cell antigen 4-1BB: analysis of expression and function. J. Immunol. 150:771.
26. Peschon, J. J., P. J. Morrissey, K. H. Grabstein, F. J. Ramsdell, E. Maraskovsky, B. C. Gliniak, L. S. Park, S. F. Ziegler, D. E. Williams, C. B. Ware, J. D. Meyer, and B. L. Davidson. 1994. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180:1955.
27. + T cell functions. J. Exp. Med. 183:2209.
28. Karasuyama, H., and F. Melchers. 1988. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5 using modified cDNA expression vectors. Eur. J. Immunol. 18:97.
29. 2-microglobulin constructs. J. Immunol. 160:1598.
30. Baez, M., P. Palese, and E. D. Kilbourne. 1980. Gene composition of high-yielding influenza vaccine strains obtained by recombination. J. Infect. Dis. 141: 362.
31. lck. Eur. J. Immunol. 25:3155.
32. Bachmann, M. F., K. McKall-Faienza, R. Schmits, D. Bouchard, J. Beach, D. E. Speiser, T. W. Mak, and P. S. Ohashi. 1997. Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation. Immunity 7:549.
33. Oehen, S., and K. Brduscha-Riem. 1998. Differentiation of naive CTL to effector and memory CTL: Correlation of effector function with phenotype and cell division. J. Immunol. 161:5338.
34. Lens, S. M. A., K. Tesselaar, M. H. J. van Oers, and R. A. W. van Lier. 1998. Control of lymphocyte function through CD27-CD70 interaction. Semin. Immunol. 10:491.
35. Weinberg, A. D., A. T. Vella, and M. Croft. 1998. OX-40: life beyond the effector T cell stage. Semin. Immunol. 10:471.
36. Larsen, C. P., E. T. Elwood, D. Z. Alexander, S. C. Ritchie, R. Hendrix, C. Tucker-Burden, H. R. Cho, A. Aruffo, D. Hollenbaugh, P. S. Linsley, K. J. Winn, and T. C. Pearson. 1996. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 381:434.
37. Kato, T., R. Hakamada, H. Yamane, and H. Nariuchi. 1996. Induction of IL-12 p40 messenger RNA expression and IL-12 production of macrophages via CD40-CD40 ligand interaction. J. Immunol. 156:3932.
38. Hartwig, U. F., L. Karlsson, P. A. Peterson, and S. R. Webb. 1997. CD40 and IL-4 regulate murine CD27L expression. J. Immunol. 159:6000.
39. Langstein, J., J. Michel, J. Fritsche, M. Kreutz, R. Andreesen, and H. Schwarz. 1998. CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling. J. Immunol. 160:2488.
40. Watts, T. H., and M. A. DeBenedette. 1999. T cell costimulatory molecules other than CD28. Curr. Opin. Immunol. 11:286.
41. Metlay, J. P., M. D. Witmer-Pack, R. Agger, M. T. Crowley, D. Lawless, and R. M. Steinman. 1990. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J. Exp. Med. 171: 1753 .
42. Leist, T. P., S. P. Cobbold, H. Waldmann, M. Aguet, and R. M. Zinkernagel. 1987. Functional analysis of T lymphocyte subsets in antiviral host defense. J. Immunol. 133:2278.