Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

Journal of Experimental Medicine

Volumn 192, Issue 7, 2000, Pages 1027-1034

  Freeman, Gordon J ^a   Long, Andrew J ^b   Iwai, Yoshiko ^c   Bourque, Karen ^b   Chernova, Tatyana ^a   Nishimura, Hiroyuki ^c   Fitz, Lori J ^b   Malenkovich, Nelly ^a   Okazaki, Taku ^c   Byrne, Michael C ^b   Horton, Heidi F ^b   Fouser, Lynette ^b   Carter, Laura ^b   Ling, Vincent ^b   Bowman, Michael R ^b   Carreno, Beatriz M ^b   Collins, Mary ^b   Wood, Clive R ^b   Honjo, Tasuku ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b PFIZER INC   (United States)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Binding; Cytokine secretion inhibition; Peripheral tolerance; Proliferation inhibition; Tissue expression

Indexed keywords

CD28 ANTIGEN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; PD1 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; BONE MARROW CELL; CYTOKINE RELEASE; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; INFLAMMATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MONOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD3; ANTIGENS, CD80; ANTIGENS, CD86; ANTIGENS, SURFACE; APOPTOSIS REGULATORY PROTEINS; BASE SEQUENCE; CELL DIVISION; DNA, COMPLEMENTARY; GENE EXPRESSION; HUMANS; LIGANDS; MEMBRANE GLYCOPROTEINS; MICE; MOLECULAR SEQUENCE DATA; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0034596948     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.7.1027     Document Type: Article

References (28)

1. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
2. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
3. Activation-induced expression of human programmed death-1 gene in T-lymphocytes
4. Structure and chromosomal localization of the human PD-1 gene (PDCD1)
5. Immunoreceptor tyrosine-based inhibition motifs
6. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
7. The complexities of T-cell costimulation: CD28 and beyond
8. The emerging role of CTLA-4 as an immune attenuator
9. CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location
10. The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-B1 (CD80), resolving the question regarding a third CD28/CTLA-4 counter receptor
11. Identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor
12. CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X(L) induction
13. Preparation of mRNA for expression monitoring
14. CTLA-4 and CD28 are coexpressed in most T-cells after activation
15. The role of B7-1/B7-2:CD28/CTLA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response
16. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
17. B7h, a novel costimulatory homolog of B7-1 and B7-2, is induced by TNFα
18. T-cell co-stimulation through B7RP-1 and ICOS
19. The costimulatory genes CD80 and CD86 are linked on mouse chromosome 16 and human chromosome 3
20. Structure and evolution of the extended B7 family
21. Immunological studies on PD-1 deficient mice: Implication of PD-1 as a negative regulator for B cell responses
22. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
23. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4
24. Discordant expression of CD28 ligands, BB-1, and B7-1 on keratinocytes in vitro and psoriatic cells in vivo
25. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family
26. Structure and dimerization of a soluble form of B7-1
27. Characterization of murine Flt4 ligand/VEGF-C
28. Selective induction of B7/BB-1 on interferon-gamma stimulated monocytes: A potential mechanism for amplification of T cell activation through the CD28 pathway