CD28-independent, TRAF2-dependent costimulation of resting T cells by 4- 1BB ligand

Journal of Experimental Medicine

Volumn 187, Issue 11, 1998, Pages 1849-1862

  Saoulli, Katina ^a   Lee, Soo Young ^c   Cannons, Jennifer L ^a   Yeh, Wen Chen ^a   Santana, Angela ^a   Goldstein, Marni D ^a   Bangia, Naveen ^a   DeBenedette, Mark A ^a   Mak, Tak W ^a   Choi, Yongwon ^b,c   Watts, Tania H ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

4 1BB; Costimulation; Signaling; T cells; TRAF2

Indexed keywords

CD28 ANTIGEN;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; BACULOVIRUS; DRUG RECEPTOR BINDING; LIGAND BINDING; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; VIRUS EXPRESSION;

ANIMALS; ANTIBODIES; ANTIGENS, CD; ANTIGENS, CD137; ANTIGENS, CD28; CELL LINE; GENETIC VECTORS; INTERLEUKIN-2; LIGANDS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NUCLEOPOLYHEDROVIRUS; PROTEINS; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; T-LYMPHOCYTES; TNF RECEPTOR-ASSOCIATED FACTOR 1; TNF RECEPTOR-ASSOCIATED FACTOR 2;

EID: 0032101119     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.11.1849     Document Type: Article

References (50)

1. Lenschow, D.J., T.L. Walunas, and J.A. Bluestone. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233-258.
2. Shahinian, A., K. Pfeffer, K.P. Lee, T.M. Kundig, K. Kishihara, A. Wakeham, K. Kawai, P.S. Ohashi, C.B. Thompson, and T.W. Mak. 1993. Differential T cell costimulatory requirements in CD28-deficient mice. Science. 261:609-612.
3. Green, J.M., P.J. Noel, A.I. Sperling, T.L. Walunas, G.S. Gray, J.A. Bluestone, and C.B. Thompson. 1994. Absence of B7-dependent responses in CD28-deficient mice. Immunity. 1:501-508.
4. Kawai, K., A. Shahinian, T.W. Mak, and P.S. Ohashi. 1996. Skin allograft rejection in CD28-deficient mice. Transplantation. 61:352-355.
5. Kwon, B.S., and S.M. Weissman. 1989. cDNA sequences of two inducible T-cell genes. Proc. Natl. Acad. Sci. USA. 86: 1963-1967.
6. Pollok, K.E., Y.-J. Kim, Z. Zhou, J. Hurtado, K.K. Kim, R. T. Pickard, and B.S. Kwon. 1993 Inducible T cell antigen 4-1BB: analysis of expression and function. J. Immunol. 150: 771-781.
7. Goodwin, R.G., W.S. Din, T. Davis-Smith, D.M. Anderson, S. D. Gimpel, T.A. Sato, C.R. Maliszewski, C.I. Brannan, N.G. Copeland, N.A. Jenkins, et al. 1993. Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur. J. Immunol. 23:2631-2641.
8. Alderson, M.R., C.A. Smith, T.W. Tough, T. Davis-Smith, R.J. Armitage, B. Falk, E. Roux, E. Baker, G.R. Sutherland, W.S. Din, and R.G. Goodwin. 1994. Molecular and biological characterization of human 4-1BB and its ligand. Eur. J. Immunol. 24:2219-2227.
9. Pollok, K.E., Y.-J. Kim, J. Hurtado, Z. Zhou, K.K. Kim, and B.S. Kwon. 1994. 4-1BB T cell antigen binds to mature B cells and macrophages, and costimulates anti-μ-primed splenic B cells. Eur. J. Immunol. 24:367-374.
10. DeBenedette, M.A., N.R. Chu, K.E. Pollok, J. Hurtado, W.F. Wade, B.S. Kwon, and T.H. Watts. 1995. Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP. J. Exp. Med. 181:985-992.
11. - T lymphocytes by 4-1BB ligand. J. Immunol. 158:551-559.
12. Hurtado, J.C., Y.-J. Kim, and B.S. Kwon. 1997. Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death. J. Immunol. 158:2600-2609.
13. Melero, I., W.W. Shuford, S.A. Newby, A. Aruffo, J.A. Ledbetter, K.E. Hellstrom, R.S. Mittler, and L. Chen. 1997. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat. Med. 3:682-685.
14. + T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J. Exp. Med. 186:47-55.
15. Hurtado, J.C., S.H. Kim, K.E. Pollok, Z.H. Lee, and B.S. Kwon. 1995. Potential role of 4-1BB in T cell activation: comparison with the costimulatory molecule CD28. J. Immunol. 155:3360-3367.
16. - T cells. J. Immunol. 158:3081-3089.
17. Hu, H.M., K. O'Rourke, M.S. Boguski, and V.M. Dixit. 1994. A novel RING finger protein interacts with the cytoplasmic domain of CD40. J. Biol. Chem. 269:30069-30072.
18. Rothe, M., S.C. Wong, W.J. Henzel, and D.G. Goeddel. 1994. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell. 78:681-692.
19. Cheng, G., A.M. Cleary, Z.-S. Ye, D.I. Hong, S. Lederman, and D. Baltimore. 1995. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Scince. 267:1494-1498.
20. Mosialos, G., M. Birkenbach, R. Yalamanchili, T. VanArsdale, C. Ware, and E. Kieff. 1995. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell. 80:389-399.
21. Régnier, C.H., C. Tomasetto, C. Moog-Lutz, M.-P. Chenard, C. Wendling, P. Basset, and M.-C. Rio. 1995. Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma. J. Biol. Chem. 270:25715-25721.
22. Song, H.Y., and D.B. Donner. 1995. Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor. Biochem. J. 309:825-829.
23. Sato, T., S. Irie, and J.C. Reed. 1995. A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. FEBS Lett. 358:113-118.
24. Nakano, H., H. Oshima, W. Chung, L. Williams-Abbott, C.F. Ware, H. Yagita, and K. Okumura. 1996. TRAF5, an activator of NF-κB and putative signal transducer for the lymphotoxin-β receptor. J. Biol. Chem. 271:14661-14664.
25. Cao, Z., J. Xiong, M. Takeuchi, T. Kurama, and D.V. Goeddel. 1996. TRAF6 is a signal transducer for interleukin-1. Science. 383:443-446.
26. Rothe, M., V. Sarma, V.M. Dixit, and D.V. Goeddel. 1995. TRAF2-mediated activation of NF-κB by TNF receptor 2 and CD40. Science 269:1424-1427.
27. Takeuchi, M., M. Rothe, and D.V. Goeddel. 1996. Anatomy of TRAF2: distinct domains for nuclear factor-κB activation and association with tumor necrosis factor signaling proteins. J. Biol. Chem. 271:19935-19942.
28. Lee, S.Y., C.G. Park, and Y. Choi. 1996. T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors. J. Exp. Med. 183:669-674.
29. Ansieau, S., I. Scheffrahn, G. Mosialos, H. Brand, J. Duyster, K. Kaye, J. Harada, B. Dougall, G. Hubinger, E. Kieff, et al. 1996. Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with CD30 cytoplasmic domain: TRAF-2 mediates CD30-induced nuclear factor kappa B activation. Proc. Natl. Acad. Sci. USA. 93:14053-14058.
30. Boucher, L.-M., L.E.M. Marengere, Y. Lu, S. Thukral, and T.W. Mak. 1997. Binding sites of cytoplasmic effectors TRAF1, 2 and 3 on CD30 and other members of the TNF receptor superfamily. Biochem. Biophys. Res. Commun. 233: 592-600.
31. Gedrich, R.W., M.C. Gilfillan, C.S. Duckett, J.L. Van Dongen, and C.B. Thompson. 1996. CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins. J. Biol. Chem. 271:12852-12858.
32. Liu, Z.-g., H. Hsu, D.V. Goeddel, and M. Karin. 1996. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell. 87:565-576.
33. Natoli, G., A. Costanzo, A. Ianni, D.J. Templeton, J.R. Woodgett, C. Balsano, and M. Levrero. 1997. Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway. Science. 275:200-203.
34. Reinhard, C., B. Shamoon, V. Shyamala, and L.T. Williams 1997. Tumor necrosis factor α-induced activation of c-jun N-terminal kinase is mediated by TRAF2. EMBO (Eur. Mol. Biol. Organt.) J. 16:1080-1092.
35. Lee, S.Y., A. Reichlin, A. Santana, K.A. Sokol, M.C. Nussenzweig, and Y. Choi. 1997. TRAF2 is essential for JNK but not NF-κB activation and regulates lymphocyte proliferation and survival. Immunity. 7:703-713.
36. Yeh, W.-C., A. Shahinian, D. Speiser, J. Kraunus, F. Billia, A. Wakeham, J.L. de la Pompa, D. Ferrick, B. Hum, N. Iscove, et al. 1997. Early lethality, functional NF-κB activation and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity. 7:715-725.
37. Kim, K.J., C. Kanellopoulos-Langevin, R.M. Merwin, D.H. Sachs, and R.A. Asofsky. 1979. Establishment and characterization of Balb/c lymphoma lines with B cell properties. J. Immunol. 122:549-554.
38. Speiser, D.E., S.Y. Lee, B. Wong, J. Arron, A. Santana, Y.-Y. Kong, P.S. Ohashi, and Y. Choi. 1997. A regulatory role for TRAF1 in antigen-induced apoptosis of T cells. J. Exp. Med. 185:1777-1783.
39. Leo, O., M. Foo, D.H. Sachs, L.E. Samelson, and J.A. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA. 84: 1374-1378.
40. Field, J., J.-I. Nikawa, D. Broek, B. MacDonald, L. Rodgers, I.A. Wilson, R.A. Lerner, and M. Wigler. 1988. Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyres cerevisiae by use of an epitope addition method. Mol. Cell. Biol. 8:2159-2165.
41. Gross, J.A., E. Callas, and J.P. Allison. 1992. Identification and distribution of the costimulatory receptor CD28 in the mouse. J. Immunol. 149:380-388.
42. Attia, J., S. Gupta, and R.J. Dunn. 1995. Expression and secretion of a soluble form of myelin-associated glycoprotein (MAG). In Methods in Molecular Biology, Vol. 39: Baculovirus Expression Protocols. C.D. Richardson, editor. Humana Press Inc., Totowa, NJ. 363-384.
43. Lalumière, M., and C.D. Richardson. 1995. Production of recombinant baculoviruses using rapid screening vectors that contain the gene for β-galactosidase. In Methods in Molecular Biology, Vol. 39: Baculovirus Expression Protocols. C.D. Richardson, editor. Humana Press Inc., Totowa, NJ. 161-177.
44. Kuhne, M.R., J.E. Hambor, M.F. Mackey, Y. Kosaka, T. Nishimura, J.P. Gigley, R.J. Noelle, and D.M. Calderhead. 1997. Assembly and regulation of the CD40 receptor complex in human B cells. J. Exp. Med. 186:377-342.
45. Kwon, B.S., G.S. Kim, M.B. Prystowsky, D.W. Lancki, D.E. Sabath, J.L. Pan, and S.M. Weissman. 1987. Isolation and initial characterization of multiple species of T-lymphocyte subset cDNA clones. Proc. Natl. Acad. Sci. USA. 84:2896-2900.
46. Schwartz, R.H. 1996. Models of T cell anergy: is there a common molecular mechanism?. Exp. Med. 184:1-8.
47. Kündig, T.M., A. Shahinian, K. Kawai, H.-W. Mittrücker. E. Sebzda, M.F. Bachmann, T.W. Mak, and P.S. Ohashi. 1996. Duration of TCR stimulation determines costimulatory requirement of T cells. Immunity. 5:41-52.
48. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell. 77:727-736.
49. Arch, R.H., and C.B. Thompson. 1998. 4-1BB and OX40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor κB. Mol. Cell. Biol. 18: 558-565.
50. Jang, I.K., Z.H. Lee, Y.J. Kim, S.H. Kim, and B.S. Kwon. 1998. Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-κB. Biochem. Biophys. Res. Commun. 242:613-620.