Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity

Nature Medicine

Volumn 9, Issue 5, 2003, Pages 562-567

  Curiel, Tyler J ^a   Wei, Shuang ^a   Dong, Haidong ^b   Alvarez, Xavier ^a   Cheng, Pui ^a   Mottram, Peter ^a   Krzysiek, Roman ^c   Knutson, Keith L ^d   Daniel, Ben ^a   Zimmermann, Maria Carla ^a   David, Odile ^a   Burow, Matthew ^a   Gordon, Alan ^e   Dhurandhar, Nina ^a   Myers, Leann ^a   Berggren, Ruth ^a   Hemminki, Akseli ^f   Alvarez, Ronald D ^f   Emilie, Dominique ^c   Curiel, David T ^f   Chen, Lieping ^b   Zou, Weiping ^a   more..

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c INSERM   (France)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^e BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^f UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CELL SURFACE PROTEIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; PROTEIN B7 H1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CANCER; CANCER GROWTH; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CANCER PATIENT; CELL FUNCTION; CELL ISOLATION; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; DISEASE ASSOCIATION; DISEASE COURSE; DOWN REGULATION; ENVIRONMENTAL FACTOR; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE DEFICIENCY; IMMUNE RESPONSE; LYMPH NODE; MICROENVIRONMENT; MONOCYTE; MOUSE; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UPREGULATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD80; BLOOD PROTEINS; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; FEMALE; HUMANS; INTERLEUKIN-10; INTERLEUKIN-12; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED NOD; MICE, SCID; MYELOID CELLS; OVARIAN NEOPLASMS; PEPTIDES; T-LYMPHOCYTES;

ANIMALIA;

EID: 0038273853     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm863     Document Type: Article

References (37)

1. Banchereau, J. & Steinman, R.M. Dendritic cells and the control of immunity. Nature 392, 245-252 (1998).
2. Zitvogel, L. et al. Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines. J. Exp. Med. 183, 87-97 (1996).
3. Zitvogel, L. et al. IL-12-engineered dendritic cells serve as effective tumor vaccine adjuvants in vivo. Ann. NY Acad. Sci. 795, 284-293 (1996).
4. Mayordomo, J.I. et al. Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity. Nat. Med. 1, 1297-1302 (1995).
5. Nestle, F.O., Banchereau, J. & Hart, D. Dendritic cells: on the move from bench to bedside. Nat. Med. 7, 761-765 (2001).
6. Hsu, F.J. et al. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nat. Med. 2, 52-58 (1996).
7. Pardoll, D. T cells and tumors. Nature 411, 1010-1012 (2001).
8. Zou, W. et al. Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells. Nat. Med. 7, 1339-1346 (2001).
9. Gabrilovich, D.I. et al. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat. Med. 2, 1096-1103 (1996).
10. Dong, H., Zhu, G., Tamada, K. & Chen, L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 5, 1365-1369 (1999).
11. Tamura, H. et al. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 97, 1809-1816 (2001).
12. Dong, H. et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 8, 793-800 (2002).
13. Freeman, G.J. et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192, 1027-1034 (2000).
14. Agata, Y. et al. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 8, 765-772 (1996).
15. Nishimura, H., Nose, M., Hiai, H., Minato, N. & Honio, T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11, 141-151 (1999).
16. Nishimura, H. et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 291, 319-322 (2001).
17. Mazanet, M.M. & Hughes, C.C. B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis. J. Immunol. 169, 3581-3588 (2002).
18. Steinbrink, K., Wolfl, M., Jonuleit, H., Knop, J. & Enk, A.H. Induction of tolerance by IL-10-treated dendrit[c cells. J. Immunol. 159, 4772-4780 (1997).
19. Loercher, A.E., Nash, M.A., Kavanagh, J.J., Platsoucas, C.D. & Freedman, R.S. Identification of an IL-10-producing HLA-DR-negative monocyte subset in the malignant ascites of patients with ovarian carcinoma that inhibits cytokine protein expression and proliferation of autologous T cells. J. Immunol. 163, 6251-6260 (1999).
20. Carmeliet, P. & Jain, R.K. Angiogenesis in cancer and other diseases. Nature 407, 249-257 (2000).
21. Menetrier-Caux, C. et al. Inhibition of the differentiation of dendritic cells from CD34(+) progenitors by tumor cells: role of interleukin-6 and macrophage colonystimulating factor. Blood 92, 4778-4791 (1998).
22. Bennett, S.R. et al. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393, 478-480 (1998).
23. + T-helper and a T-killer cell. Nature 393, 474-478 (1998).
24. Schoenberger, S.P., Toes, R.E., van der Voort, E.I., Offringa, R. & Melief, C.J. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393, 480-483 (1998).
25. Chang, C.C. et al. Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. Nat. Immunol. 3, 237-243 (2002).
26. Trinchieri, G. & Scott, P. Interleukin-12: basic principles and clinical applications. Curr. Top. Microbiol. Immunol. 238, 57-78 (1999).
27. Dong, H. et al. Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis. J. Clin. Invest. 111:363-370, 2003
28. Wang, S.-D. et al. Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. J. Exp. Med. In press.
29. Takahashi, A. et al. Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis. Cancer Res. 54, 4233-4237 (1994).
30. Takahashi, Y., Kitadai, Y., Bucana, C.D., Cleary, K.R. & Ellis, L.M. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res. 55, 3964-3968 (1995).
31. Brown, L.F. et al. Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas. Am. J. Pathol. 143, 1255-1262 (1993).
32. Toi, M. et al. Quantitative analysis of vascular endothelial growth factor in primary breast cancer. Cancer 77, 1101-1106 (1996).
33. Zou, W. et al. Macrophage-derived dendritic cells have strong Th1-polarizing potential mediated by β-chemokines rather than IL-12. J. Immunol. 165, 4388-4396 (2000).
34. Zou, W. et al. Quantification of cytokine gene expression by competitive PCR using a colorimetric assay. Eur. Cytokine Netw. 6, 257-264 (1995).
35. Strome, S.E. et al. Strategies for antigen loading of dendritic cells to enhance the antitumor immune response. Cancer Res. 62, 1884-1889 (2002).
36. Llorente, L. et al. Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J. Exp. Med. 181, 839-844 (1995).
37. Mesiano, S., Ferrara, N. & Jaffe, R.B. Role of vascular endothelial growth factor in ovarian cancer: inhibition of ascites formation by immunoneutralization. Am. J. Pathol. 153, 1249-1256 (1998).