Distinct Roles for the OX40-OX40 Ligand Interaction in Regulatory and Nonregulatory T Cells

Journal of Immunology

Volumn 172, Issue 6, 2004, Pages 3580-3589

  Takeda, Ikuo ^a   Ine, Shoji ^a   Killeen, Nigel ^b   Ndhlovu, Lishomwa C ^a   Murata, Kazuko ^a   Satomi, Susumu ^a   Sugamura, Kazuo ^a   Ishii, Naoto ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD134 ANTIGEN; LIGAND;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL FUNCTION; CELL MATURATION; CONTROLLED STUDY; HOMEOSTASIS; LIGAND BINDING; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPENIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 1542514775     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.6.3580     Document Type: Article

References (60)

1. Sakaguchi, S. 2000. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 101:455.
2. + regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182:18.
3. + suppressor T cells. Immunol. Rev. 182:58.
4. Chatenoud, L., B. Salomon, and J. A. Bluestone. 2001. Suppressor T cells-they're back and critical for regulation of autoimmunity. Immunol. Rev. 182:149.
5. Singh, B., S. Read, C. Asseman, V. Malmström, C. Mottet, L. A. Stephens, R. Stepankova, H. Tlaskalova, and F. Powrie. 2001. Control of intestinal inflammation by regulatory T cells. Immunol. Rev. 182:190.
6. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:389.
7. + T cells. Immunity 1:553.
8. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151.
9. Asano, M., M. Toda, N. Sakaguchi, and S. Sakaguchi. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:387.
10. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12:431.
11. Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A. C. Feller, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75:253.
12. + T cells. Eur. J. Immunol. 25:3053.
13. Willerford, D. M., J. Chen, J. Ferry, L. Davidson, A. Ma, and F. W. Alt. 1995. Interleukin-2 receptor a chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3:521.
14. Suzuki, H., T. M. Kunding, C. Furlonger, A. Wakeham, E. Timms, T. Matsuyama, R. Schmits, J. J. Simard, P. S. Ohashi, H. Griesser, et al. 1995. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β. Science 268:1472.
15. Malek, T. R., A. Yu, V. Vincek, P. Scibelli, and L. Kong. 2002. CD4 regulatory T cells prevent lethal autoimmunity in IL-2R β-deficient mice: implications for the ponredundant function of IL-2. Immunity 17:167.
16. + regulatory T cell function. J. Exp. Med. 196:851.
17. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287.
18. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10:1969.
19. + suppressor T cells in vivo. Nat. Immunol. 3:33.
20. + regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295.
21. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192:303.
22. + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3:135.
23. + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16:311.
24. Mallett, S., S. Fossum, and A. N. Barclay. 1990. Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes - a molecule related to nerve growth factor receptor. EMBO J. 9:1063.
25. tax. Mol. Cell. Biol. 11:1313.
26. Baum, P. R., R. B. Gayle III, F. Ramsdell, S. Srinivasan, R. A. Sorensen, M. L. Watson, M. F. Seldin, E. Baker, G. R. Sutherland, K. N. Clifford, et al. 1994. Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. EMBO J. 13:3992.
27. + T cells with homology to tumor necrosis factor. J. Exp. Med. 180:757.
28. Paterson, D. J., W. A. Jefferies, J. R. Green, M. R. Brandon, P. Corthesy, M. Puklavec, and A. F. Williams. 1987. Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol. Immunol. 24:1281.
29. Stüber, E., M. Neurath, D. Calderhead, H. P. Fell, and W. Strober. 1995. Crosslinking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity 2:507.
30. Ohshima, Y., Y. Tanaka, H. Tozawa, Y. Takahashi, C. Maliszewski, and G. Delespesse. 1997. Expression and function of OX40 ligand on human dendritic cells. J. Immunol. 159:3838.
31. Brocker, T., A. Gulbranson-Judge, S. Flynn, M. Riedinger, C. Raykundalia, and P. Lane. 1999. CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles. Eur. J. Immunol. 29:1610.
32. Weinberg, A. D., K. W. Wegmann, C. Funatake, and R. H. Whitham. 1999. Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis. J. Immunol. 162:1818.
33. Imura, A., T. Hori, K. Imada, T. Ishikawa, Y. Tanaka, M. Maeda, S. Imamura, and T. Uchiyama. 1996. The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells. J. Exp. Med. 183:2185.
34. Pippig, S. D., C. Pena-Rossi, J. Long, W. R. Godfrey, D. J. Fowell, S. L. Reiner, M. L. Birkeland, R. M. Locksley, A. N. Barclay, and N. Killeen. 1999. Robust B cell immunity but impaired T cell proliferation in the absence of CD 134 (OX40). J. Immunol. 163:6520.
35. Chen, A. I., A. J. McAdam, J. E. Buhlmann, S. Scott, M. L. Lupher, Jr., E. A. Greenfield, P. R. Baum, W. C. Fanslow, D. M. Calderhead, G. J. Freeman, and A. H. Sharpe. 1999. Ox40-ligand has a critical costimulatory role in dendritic cell: T cell interactions. Immunity 11:689.
36. Kopf, M., C. Ruedl, N. Schmitz, A. Gallimore, K. Lefrang, B. Ecabert, B. Odermatt, and M. F. Bachmann. 1999. OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL responses after virus infection. Immunity 11:699.
37. Murata, K., N. Ishii, H. Takano, S. Miura, L. C. Ndhlovu, M. Nose, T. Noda, and K. Sugamura. 2000. Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. J. Exp. Med. 191:365.
38. Maxwell, J. R., A. Weinberg, R. A. Prell, and A. T Vella. 2000. Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion. J. Immunol. 164:107.
39. Gramaglia, I., A. Jember, S. D. Pippig, A. D. Weinberg, N. Killeen, and M. Croft. 2000. The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion. J. Immunol. 165:3043.
40. Rogers, P. R., J. Song, I. Gramaglia, N. Killeen, and M. Croft. 2001. OX40 promotes Bcl-XL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity 15:445.
41. Bansal-Pakala, P. B., A. G. H. Jember, and M. Croft. 2001. Signaling through OX40 (CD134) breaks peripheral T-cell tolerance. Nat. Med. 7:907.
42. +) T cells with chronic graft-versus-host disease in patients who underwent allogeneic hematopoietic stem cell transplantation. Blood 98:3162.
43. Aten, J., A. Roos, N. Claessen, E. J. Schilder-Tol, I. J. Ten Berge, and J. J. Weening. 2000. Strong and selective glomerular localization of CD134 ligand and TNF receptor-1 in proliferative lupus nephritis. J. Am. Soc. Nephrol. 11:1426.
44. Giacomelli, R., A. Passacantando, R. Perricone, I. Parzanese, M. Rascente, G. Minisola, and G. Tonietti. 2001. T lymphocytes in the synovial fluid of patients with active rheumatoid arthritis display CD134-OX40 surface antigen. Clin. Exp. Rheumatol. 19:2317.
45. 7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patient with inflammatory bowel disease. Gut 45:856.
46. Stüber, E., A. Buschenfeld, J. Luttges, A. Von Freier, T. Arendt, and U. R. Folsch. 2000. The expression of OX40 in immunologically mediated diseases of the gastrointestinal tract (celiac diseases, Crohn's disease, ulcerative colitis). Eur. J. Clin. Invest. 30:594.
47. Tateyama, M., K. Fujihara, N. Ishii, K. Sugamura, Y. Onodera, and Y. Itoyama. 2002. Expression of OX40 in muscles of polymyositis and granulomatous myopathy. J. Neurol. Sci. 194:29.
48. Onodera, J., T. Nagata, K. Fujihara, M. Ohuchi, N. Ishii, K. Sugamura, and Y. Itoyama. 2000. Expression of OX40 and OX40 ligand (gp34) in the normal and myasthenic thymus. Acta Neurol. Scand. 102:236.
49. Murata, K., M. Nose, L. C. Ndhlovu, T. Sato, K. Sugamura, and N. Ishii. 2002. Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases. J. Immunol. 169:4628.
50. Malmström, V., D. Shipton, B. Singh, A. Al-Shamkhani, M. J. Puklavec, A. N. Barclay. and F. Powrie. 2001. CD 134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice. J. Immunol. 166:6972.
51. Sato, T., N. Ishii, K. Murata, K. Kikuchi, S. Nakagawa, L. C. Ndhlovu, and K. Sugamura. 2002. Consequences of OX40-OX40 ligand interactions in Langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice. Eur. J. Immunol. 32:3326.
52. Asseman, C., S. Mauze, M. W. Leach, R. L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190:995.
53. Lavelle, E. C., E. McNeela, M. E. Armstrong, O. Leavy, S. C. Higgins, and K. H. Mills. 2003. Cholera toxin promotes the induction of regulatory T cells specific for bystander antigens by modulating dendritic cell activation. J. Immunol. 171:2384.
54. Baba, E., Y. Takahashi, J. Lichtenfeld, R. Tanaka, A. Yoshida, K. Sugamura, N. Yamamoto, and Y. Tanaka. 2001. Functional CD4 T cells after intercellular molecular transfer of OX40 ligand. J. Immunol. 167:875.
55. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 164: 183.
56. Ndhlovu, L. C., N. Ishii, K. Murata, T. Sato, and K. Sugamura. 2001. Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis. J. Immunol. 167:2991.
57. + T regulatory cells suppress Helicobacter hepaticus-induced colitis. J. Exp. Med. 196:505.
58. Campieri, M., and P. Gionchetti. 1999. Probiotics in inflammatory bowel disease: new insight to pathogenesis or a possible therapeutic alternative? Gastroenterology 116:1246.
59. Linton, P. J., B. Bautista, E. Biederman, E. S. Bradley, J. Harbertson, R. M. Kondrack, R. C. Padrick, and L. M. Bradley. 2003. Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo. J. Exp. Med. 197:875.
60. + T cell-mediated suppression by dendritic cells. Science 299:1033.