A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma

Journal of Translational Medicine

Volumn 9, Issue 1, 2011, Pages

  Hamid, Omid ^a   Schmidt, Henrik ^b   Nissan, Aviram ^c   Ridolfi, Laura ^d   Aamdal, Steinar ^e   Hansson, Johan ^f   Guida, Michele ^g   Hyams, David M ^h   Gómez, Henry ⁱ   Bastholt, Lars ^j   Chasalow, Scott D ^k   Berman, David ^k  

^a Angeles Clinic and Research Institute   (United States)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^d DEPARTMENT OF MEDICAL ONCOLOGY   (Italy)

^e OSLO UNIVERSITY HOSPITAL   (Norway)

^f KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^g NATIONAL CANCER INSTITUTE GIOVANNI PAOLO II   (Italy)

^h Desert Surgical Oncology   (United States)

ⁱ INSTITUTO NACIONAL DE ENFERMEDADES NEOPLÁSICAS   (Peru)

^j ODENSE UNIVERSITY HOSPITAL   (Denmark)

^k BRISTOL MYERS SQUIBB   (United States)

more..

Author keywords

Cytotoxic t lymphocyte antigen 4; Foxp3; Indoleamine 2,3 dioxygenase; Ipilimumab; Melanoma; Tumor biomarker; Tumor infiltrating lymphocytes

Indexed keywords

INDOLEAMINE 2,3 DIOXYGENASE; IPILIMUMAB; MESSENGER RNA; TRANSCRIPTION FACTOR FOXP3; TUMOR MARKER; ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY;

ADULT; ADVANCED CANCER; AGED; ANTINEOPLASTIC ACTIVITY; ARTICLE; BTNL2 GENE; CANCER STAGING; CCR5 GENE; CD86 GENE; CONTROLLED STUDY; CTLA 4 GENE; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG FATALITY; DRUG SAFETY; DRUG WITHDRAWAL; ENDOCRINE DISEASE; FEMALE; GASTROINTESTINAL SYMPTOM; GENE; GENE EXPRESSION PROFILING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IFNAR1 GENE; IFNAR2 GENE; IFNG GENE; IL23R GENE; IMMUNOHISTOCHEMISTRY; INOPERABLE CANCER; INTESTINE PERFORATION; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; MELANOMA; MICROARRAY ANALYSIS; MULTICENTER STUDY; NOD2 GENE; PHARMACODYNAMICS; PHASE 2 CLINICAL TRIAL; PREDICTIVE VALUE; PROSPECTIVE STUDY; PROTEIN EXPRESSION; PTPN22 GENE; RANDOMIZED CONTROLLED TRIAL; SKIN TOXICITY; TREATMENT DURATION; TREATMENT RESPONSE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR BIOPSY; TUMOR MICROENVIRONMENT; UNSPECIFIED SIDE EFFECT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; SKIN TUMOR; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA; MIDDLE AGED; NEOPLASM STAGING; POLYMORPHISM, GENETIC; PROSPECTIVE STUDIES; RNA, MESSENGER; SKIN NEOPLASMS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; TUMOR MICROENVIRONMENT; YOUNG ADULT;

EID: 82155168544     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-9-204     Document Type: Article

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