Immunologic self-tolerance maintained by CD25+CD4+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4

Journal of Experimental Medicine

Volumn 192, Issue 2, 2000, Pages 303-309

  Takahashi, Takeshi ^a   Tagami, Tomoyuki ^b   Yamazaki, Sayuri ^a   Uede, Toshimitsu ^c   Shimizu, Jun ^b   Sakaguchi, Noriko ^a   Mak, Tak W ^d   Sakaguchi, Shimon ^a  

^a KYOTO UNIVERSITY   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Autoimmune disease; Cd25; CTLA 4; Regulatory T cell; Self tolerance

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2 RECEPTOR;

ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; CELL PROLIFERATION; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOLOGY; IMMUNOREGULATION; MOUSE; NONHUMAN; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; IMMUNE TOLERANCE; IMMUNOCONJUGATES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, SCID; RECEPTORS, INTERLEUKIN-2;

EID: 0034679560     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.2.303     Document Type: Article

References (31)

1. Thompson, C.B., and J.P. Allison. 1997. The emerging role of CTLA-4 as an immune attenuator. Immunity. 7:445-450.
2. Bluestone, J.A. 1997. Is CTLA-4 a master switch for peripheral T cell tolerance? J. Immunol. 158:1989-1993.
3. Waterhouse, P., J.M. Penninger, E. Timms, A. Wakeham, A. Shahinian, K.P. Lee, C.B. Thompson, H. Griesser, and T.W. Mak. 1995. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science. 270:985-988.
4. Tivol, E.A., F. Borriello, A.N. Schweitzer, W.P. Lynch, J.A. Bluestone, and A.M. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 3:541-547.
5. Karandikar, N.J., C.L. Vanderlugt, T.L. Walunas, S.D. Miller, and J.A. Bluestone. 1996. CTLA-4: a negative regulator of autoimmune disease. J. Exp. Med. 184:783-788.
6. Perrin, P.J., J.H. Maldonado, T.A. Davis, C.H. June, and M.K. Racke. 1996. CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis. J. Immunol. 157:1333-1336.
7. Luhder, F., P. Hoglund, J.P. Allison, C. Benoist, and D. Mathis. 1998. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J. Exp. Med. 187:427-432.
8. Leach, D.R., M.F. Krummel, and J.P. Allison. 1996. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 271:1734-1736.
9. Perez, V.L., L. Van Parijs, A. Biuckians, X.X. Zheng, T.B. Strom, and A.K. Abbas. 1997. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity. 6:411-417.
10. Bachmann, M.F., G. Kohler, B. Ecabert, T.W. Mak, and M. Kopf. 1999. Lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous. J. Immunol. 163:1128-1131.
11. Moller, G. 1996. Dominant immunological tolerance. Immunol. Rev. 149:1-243.
12. Sakaguchi, S., K. Fukuma, K. Kuribayashi, and T. Masuda. 1985. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance: deficit of a T cell subset as a possible cause of autoimmune disease. J. Exp. Med. 161:72-85.
13. low subset. J. Exp. Med. 172:1701-1708.
14. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151-1164.
15. Asano, M., M. Toda, N. Sakaguchi, and S. Sakaguchi. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:387-396.
16. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol. 160: 1212-1218.
17. + T cells: a common basis between tumor immunity and autoimmunity. J. Immunol. 163:5211-5218.
18. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10:1969-1980.
19. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162: 5317-5326.
20. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287-296.
21. Shahinian, A., K. Pfeffer, K.P. Lee, T.M. Kundig, K. Kishihara, A. Wakeham, K. Kawai, P.S. Ohashi, C.B. Thompson, and T.W. Mak. 1993. Differential T cell co-stimulatory requirements in CD28-deficient mice. Science. 261:609-612.
22. Walunas, T.L., D.J. Lenschow, C.Y. Bakker, P.S. Linsley, G.J. Freeman, J.M. Green, C.B. Thompson, and J.A. Bluestone. 1994. CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1:405-413.
23. Krummel, M.F., and Allison, J.P. 1995. CD28 and CTLA-4 have opposing effects of the response of T cells to stimulation. J. Exp. Med. 182:459-465.
24. June, C.H., J.A. Bluestone, L.M. Nadler, and C.B. Thompson. 1994. The B7 and CD28 receptor families. Immunol. Today. 15:321-331.
25. + T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J. Immunol. 155:1032-1036.
26. Gleeson, P.A., and B.H. Toh. 1991. Molecular targets in pernicious anemia. Immunol. Today. 12:233-238.
27. + T cells: a population of T cells with immune regulatory activities in vitro. Eur. J. Immunol. 28:3435-3447.
28. Alegre, M.L., P.J. Noel, B.J. Eisfelder, E. Chuang, M.R. Clark, S.L. Reiner, and C.B. Thompson. 1996. Regulation of surface and intracellular expression of CTLA-4 on mouse T cells. J. Immunol. 157:4762-4770.
29. Fallarino, F., P.E. Fields, and T.F. Gajewski. 1998. B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28. J. Exp. Med. 188:205-210.
30. + T cells. J. Exp. Med. 188:1849-1857.
31. + regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295-302.