The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses

Journal of Clinical Investigation

Volumn 115, Issue 3, 2005, Pages 711-717

  Wang, Yang ^a   Subudhi, Sumit K ^a   Anders, Robert A ^a   Lo, James ^a   Sun, Yonglian ^a   Blink, Sarah ^a   Wang, Yugang ^a   Wang, Jing ^a   Liu, Xiaojuan ^a   Mink, Karin ^b   Degrandi, Daniel ^c   Pfeffer, Klaus ^c   Fu, Yang Xin ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CONCANAVALIN A; CYTOKINE; HERPESVIRUS ENTRY MEDIATOR; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE HEPATITIS; BRAIN DISEASE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; HERPES VIRUS; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; CONCANAVALIN A; CYTOKINES; DISEASE SUSCEPTIBILITY; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HUMANS; LIVER; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, MEMBER 14; RECEPTORS, VIRUS; SPLEEN; SURVIVAL RATE; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14; TUMOR NECROSIS FACTOR-ALPHA;

EID: 20044389839     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200522982     Document Type: Article

References (35)

1. Croft, M. 2003. Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? Nat. Rev. Immunol. 3:609-620.
2. Chen, L. 2004. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat. Rev. Immunol. 4:336-347.
3. Sharpe, A.H., and Freeman, G.J. 2002. The B7-CD28 superfamily. Nat. Rev. Immunol. 2:116-126.
4. Salomon, B., and Bluestone, J.A. 2001. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu. Rev. Immunol. 19:225-252.
5. Mauri, D.N., et al. 1998. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Immunity. 8:21-30.
6. Tamada, K., et al. 2000. Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nat. Med. 6:283-289.
7. Zhai, Y., et al. 1998. LIGHT, a novel ligand for lymphotoxin β receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer. J. Clin. Invest. 102:1142-1151.
8. Rooney, I.A., et al. 2000. The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. J. Biol. Chem. 275:14307-14315.
9. Shaikh, R.B., et al. 2001. Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction. J. Immunol. 167:6330-6337.
10. Wang, J., et al. 2001. The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. J. Clin. Invest. 108:1771-1780. doi:10.1172/ JCI200113827.
11. Wang, J., et al. 2004. Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy. J. Clin. Invest. 113:826-835. doi:10.1172/JCI200420096.
12. Yu, P., et al. 2004. Priming of naive T cells inside tumors leads to eradication of established tumors. Nat. Immunol. 5:141-149.
13. Ye, Q., et al. 2002. Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survival. J. Exp. Med. 195:795-800.
14. Scheu, S., et al. 2002. Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis. J. Exp. Med. 195:1613-1624.
15. Tamada, K., et al. 2002. Cutting edge: selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT. J. Immunol. 168:4832-4835.
16. Marsters, S.A., et al. 1997. Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1. J. Biol. Chem. 272:14029-14032.
17. Granger, S.W., and Rickert, S. 2003. LIGHT-HVEM signaling and the regulation of T cell-mediated immunity. Cytokine Growth Factor Rev. 14:289-296.
18. Cauwels, A., et al. 2000. Protection against TNF-induced lethal shock by soluble guanylate cyclase inhibition requires functional inducible nitric oxide synthase. Immunity. 13:223-231.
19. Ferrara, J.L. 1995. Cytokine inhibitors and graft-versus-host disease. Ann. N. Y. Acad. Sci. 770:227-236.
20. Sun, R., Tian, Z., Kulkarni, S., and Gao, B. 2004. IL-6 prevents T cell-mediated hepatitis via inhibition of NKT cells in CD4+ T cell- and STAT3-dependent manners. J. Immunol. 172:5648-5655.
21. Tamada, K., et al. 2000. LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. J. Immunol. 164:4105-4110.
22. Lenschow, D.J., Walunas, T.L., and Bluestone, J.A. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233-258.
23. Chambers, C.A., Kuhns, M.S., Egen, J.G., and Allison, J.P. 2001. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu. Rev. Immunol. 19:565-594.
24. Dong, H., Zhu, G., Tamada, K., and Chen, L. 1999. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 5:1365-1369.
25. Tamura, H., et al. 2001. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood. 97:1809-1816.
26. Freeman, G.J., et al. 2000. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192:1027-1034.
27. Dong, H., et al. 2002. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 8:793-800.
28. Subudhi, S.K., et al. 2004. Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. J. Clin. Invest. 113:694-700. doi:10.1172/JCI200419210.
29. Chapoval, A.I., et al. 2001. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat. Immunol. 2:269-274.
30. Suh, W.K., et al. 2003. The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat. Immunol. 4:899-906.
31. Chen, L. 2002. Antibody gene therapy: old wine in a new bottle. Nat. Med. 8:333-334.
32. 1 mice. J. Clin. Invest. 111:1505-1518. doi:10.1172/JCI200317662.
33. Sun, Y., et al. 2002. Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Nat Med. 8:1405-1413.
34. Sedy, J.R., et al. 2005. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat. Immunol. 6:90-98.
35. Neubauer, H., et al. 1998. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell. 93:397-409.