메뉴 건너뛰기




Volumn 13, Issue 4, 2007, Pages 1083-1088

Prospect of targeting the CD40 pathway for cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; CD40 LIGAND MONOCLONAL ANTIBODY; CP 870 893; HCD 122; RECOMBINANT CD40 LIGAND; SGN 40; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

EID: 33947223664     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-06-1893     Document Type: Review
Times cited : (157)

References (78)
  • 1
    • 0031944607 scopus 로고    scopus 로고
    • CD40 and CD154 in cell-mediated immunity
    • Grewal IS, Flavell RA. CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol 1998;16: 111-35.
    • (1998) Annu Rev Immunol , vol.16 , pp. 111-135
    • Grewal, I.S.1    Flavell, R.A.2
  • 5
    • 0026528181 scopus 로고
    • Molecular and biological characterization of a murine ligand for CD40
    • Armitage RJ, Fanslow WC, Strockbine L, et al. Molecular and biological characterization of a murine ligand for CD40. Nature 1992;357:80-2.
    • (1992) Nature , vol.357 , pp. 80-82
    • Armitage, R.J.1    Fanslow, W.C.2    Strockbine, L.3
  • 6
    • 0037022362 scopus 로고    scopus 로고
    • Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes
    • Dadgostar H, Zarnegar B, Hoffmann A, et al. Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes. Proc Natl Acad Sci U S A 2002;99:1497-502.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 1497-1502
    • Dadgostar, H.1    Zarnegar, B.2    Hoffmann, A.3
  • 7
    • 0027414691 scopus 로고
    • CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome
    • Allen RC, Armitage RJ, Conley ME, et al. CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science 1993;259:990-3.
    • (1993) Science , vol.259 , pp. 990-993
    • Allen, R.C.1    Armitage, R.J.2    Conley, M.E.3
  • 8
    • 0035940417 scopus 로고    scopus 로고
    • Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM
    • Ferrari S, Giliani S, Insalaco A, et al. Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. Proc Natl Acad Sci U S A 2001;98:12614-9.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 12614-12619
    • Ferrari, S.1    Giliani, S.2    Insalaco, A.3
  • 9
    • 4644292965 scopus 로고    scopus 로고
    • The hyper IgM syndrome - an evolving story
    • Etzioni A, Ochs HD. The hyper IgM syndrome - an evolving story. Pediatr Res 2004;56:519-25.
    • (2004) Pediatr Res , vol.56 , pp. 519-525
    • Etzioni, A.1    Ochs, H.D.2
  • 10
    • 0027960913 scopus 로고
    • CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation
    • Castigli E, Alt FW, Davidson L, et al. CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Proc Natl Acad Sci U S A 1994;91:12135-9.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 12135-12139
    • Castigli, E.1    Alt, F.W.2    Davidson, L.3
  • 11
    • 0028447437 scopus 로고
    • The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation
    • Kawabe T, Naka T, Yoshida K, et al. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1994;1:167-78.
    • (1994) Immunity , vol.1 , pp. 167-178
    • Kawabe, T.1    Naka, T.2    Yoshida, K.3
  • 12
    • 0028135424 scopus 로고
    • Humoral immune responses in CD40 ligand-deficient mice
    • Renshaw BR, Fanslow WC III, Armitage RJ, et al. Humoral immune responses in CD40 ligand-deficient mice. J Exp Med 1994;180:1889-900.
    • (1994) J Exp Med , vol.180 , pp. 1889-1900
    • Renshaw, B.R.1    Fanslow III, W.C.2    Armitage, R.J.3
  • 13
    • 0028486131 scopus 로고
    • Mice deficient for the CD40 ligand
    • Xu J, Foy TM, Laman JD, et al. Mice deficient for the CD40 ligand. Immunity 1994;1:423-31.
    • (1994) Immunity , vol.1 , pp. 423-431
    • Xu, J.1    Foy, T.M.2    Laman, J.D.3
  • 17
    • 0032896709 scopus 로고    scopus 로고
    • CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help
    • French RR, Chan HT, Tutt AL, Glennie MJ. CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help. Nat Med 1999;5:548-53.
    • (1999) Nat Med , vol.5 , pp. 548-553
    • French, R.R.1    Chan, H.T.2    Tutt, A.L.3    Glennie, M.J.4
  • 18
    • 0032984496 scopus 로고    scopus 로고
    • CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy
    • Diehl L, den Boer AT, Schoenberger SP, et al. CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy. Nat Med 1999;5:774-9.
    • (1999) Nat Med , vol.5 , pp. 774-779
    • Diehl, L.1    den Boer, A.T.2    Schoenberger, S.P.3
  • 19
    • 0032984347 scopus 로고    scopus 로고
    • + T-cell tolerance to T-cell priming through in vivo ligation of CD40
    • + T-cell tolerance to T-cell priming through in vivo ligation of CD40. Nat Med 1999;5:780-7.
    • (1999) Nat Med , vol.5 , pp. 780-787
    • Sotomayor, E.M.1    Borrello, I.2    Tubb, E.3
  • 20
    • 0037248746 scopus 로고    scopus 로고
    • Differential regulation of cell survival by CD40
    • Dallman C, Johnson PW, Packham G. Differential regulation of cell survival by CD40. Apoptosis 2003; 8:45-53.
    • (2003) Apoptosis , vol.8 , pp. 45-53
    • Dallman, C.1    Johnson, P.W.2    Packham, G.3
  • 21
    • 0028979118 scopus 로고
    • The role of bcl-XL in CD40-mediated rescue from anti-μ-induced apoptosis in WEHI-231 B lymphoma cells
    • Choi MS, Boise LH, Gottschalk AR, Quintans J, Thompson CB, Klaus GG. The role of bcl-XL in CD40-mediated rescue from anti-μ-induced apoptosis in WEHI-231 B lymphoma cells. Eur J Immunol 1995;25:1352-7.
    • (1995) Eur J Immunol , vol.25 , pp. 1352-1357
    • Choi, M.S.1    Boise, L.H.2    Gottschalk, A.R.3    Quintans, J.4    Thompson, C.B.5    Klaus, G.G.6
  • 22
    • 0029073035 scopus 로고
    • Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis
    • Sarma V, Lin Z, Clark L, et al. Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis. J Biol Chem 1995;270:12343-6.
    • (1995) J Biol Chem , vol.270 , pp. 12343-12346
    • Sarma, V.1    Lin, Z.2    Clark, L.3
  • 23
    • 0030579195 scopus 로고    scopus 로고
    • Up-regulation of Bcl-xL expression protects CD40-activated human B cells from Fas-mediated apoptosis
    • Zhang X, Li L, Choe J, et al. Up-regulation of Bcl-xL expression protects CD40-activated human B cells from Fas-mediated apoptosis. Cell Immunol 1996; 173:149-54.
    • (1996) Cell Immunol , vol.173 , pp. 149-154
    • Zhang, X.1    Li, L.2    Choe, J.3
  • 24
    • 0033529416 scopus 로고    scopus 로고
    • NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes
    • Lee HH, Dadgostar H, Cheng Q, Shu J, Cheng G. NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Proc Natl Acad Sci U S A 1999;96:9136-41.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 9136-9141
    • Lee, H.H.1    Dadgostar, H.2    Cheng, Q.3    Shu, J.4    Cheng, G.5
  • 25
    • 0035353212 scopus 로고    scopus 로고
    • Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia
    • Granziero L, Ghia P, Circosta P, et al. Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia. Blood 2001;97:2777-83.
    • (2001) Blood , vol.97 , pp. 2777-2783
    • Granziero, L.1    Ghia, P.2    Circosta, P.3
  • 26
    • 0031788449 scopus 로고    scopus 로고
    • CD40 is functionally expressed on human breast carcinomas: Variable inducibility by cytokines and enhancement of Fas-mediated apoptosis
    • Wingett DG, Vestal RE, Forcier K, Hadjokas N, Nielson CP. CD40 is functionally expressed on human breast carcinomas: variable inducibility by cytokines and enhancement of Fas-mediated apoptosis. Breast Cancer Res Treat 1998;50:27-36.
    • (1998) Breast Cancer Res Treat , vol.50 , pp. 27-36
    • Wingett, D.G.1    Vestal, R.E.2    Forcier, K.3    Hadjokas, N.4    Nielson, C.P.5
  • 27
    • 0033579819 scopus 로고    scopus 로고
    • CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection
    • Afford SC, Randhawa S, Eliopoulos AG, Hubscher SG, Young LS, Adams DH. CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection. J Exp Med 1999;189:441-6.
    • (1999) J Exp Med , vol.189 , pp. 441-446
    • Afford, S.C.1    Randhawa, S.2    Eliopoulos, A.G.3    Hubscher, S.G.4    Young, L.S.5    Adams, D.H.6
  • 28
    • 0033152828 scopus 로고    scopus 로고
    • Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: A role for TNF-R1 activation by endogenous membrane-anchored TNF
    • Grell M, Zimmermann G, Gottfried E, et al. Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF. EMBO J 1999;18:3034-43.
    • (1999) EMBO J , vol.18 , pp. 3034-3043
    • Grell, M.1    Zimmermann, G.2    Gottfried, E.3
  • 29
    • 0033912082 scopus 로고    scopus 로고
    • CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily
    • Eliopoulos AG, Davies C, Knox PG, et al. CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily. Mol Cell Biol 2000;20:5503-15.
    • (2000) Mol Cell Biol , vol.20 , pp. 5503-5515
    • Eliopoulos, A.G.1    Davies, C.2    Knox, P.G.3
  • 30
    • 0034900413 scopus 로고    scopus 로고
    • Growth-inhibitory effects of CD40 ligand (CD154) and its endogenous expression in human breast cancer
    • Tong AW, Papayoti MH, Netto G, et al. Growth-inhibitory effects of CD40 ligand (CD154) and its endogenous expression in human breast cancer. Clin Cancer Res 2001;7:691-703.
    • (2001) Clin Cancer Res , vol.7 , pp. 691-703
    • Tong, A.W.1    Papayoti, M.H.2    Netto, G.3
  • 31
    • 4143087307 scopus 로고    scopus 로고
    • Harnett MM. CD40: a growing cytoplasmic tale. Sci STKE 2004:pe25.
    • Harnett MM. CD40: a growing cytoplasmic tale. Sci STKE 2004:pe25.
  • 32
    • 0028834403 scopus 로고
    • CD40 signaling-mediated induction of Bcl-XL, Cdk4, and Cdk6. Implication of their cooperation in selective B cell growth
    • Ishida T Kobayashi N, Tojo T, Ishida S, Yamamoto T, Inoue J. CD40 signaling-mediated induction of Bcl-XL, Cdk4, and Cdk6. Implication of their cooperation in selective B cell growth. J Immunol 1995;155: 5527-35.
    • (1995) J Immunol , vol.155 , pp. 5527-5535
    • Ishida, T.1    Kobayashi, N.2    Tojo, T.3    Ishida, S.4    Yamamoto, T.5    Inoue, J.6
  • 33
    • 0029819960 scopus 로고    scopus 로고
    • Differential modulation of cyclin-dependent kinase inhibitor p27Kip1 by negative signaling via the antigen receptor of B cells and positive signaling via CD40
    • Han H, Nomura T, Honjo T, Tsubata T. Differential modulation of cyclin-dependent kinase inhibitor p27Kip1 by negative signaling via the antigen receptor of B cells and positive signaling via CD40. Eur J Immunol 1996;26:2425-32.
    • (1996) Eur J Immunol , vol.26 , pp. 2425-2432
    • Han, H.1    Nomura, T.2    Honjo, T.3    Tsubata, T.4
  • 34
    • 0037080197 scopus 로고    scopus 로고
    • CD40 signaling in B cells regulates the expression of the Pim-1 kinase via the NF-κB pathway
    • Zhu N, Ramirez LM, Lee RL, Magnuson NS, Bishop GA, Gold MR. CD40 signaling in B cells regulates the expression of the Pim-1 kinase via the NF-κB pathway. J Immunol 2002;168:744-54.
    • (2002) J Immunol , vol.168 , pp. 744-754
    • Zhu, N.1    Ramirez, L.M.2    Lee, R.L.3    Magnuson, N.S.4    Bishop, G.A.5    Gold, M.R.6
  • 35
    • 0029941255 scopus 로고    scopus 로고
    • Maintenance of nuclear factor-κB/Rel and c-myc expression during CD40 ligand rescue of WEHI 231 early B cells from receptor-mediated apoptosis through modulation of IκB proteins
    • Schauer SL, Wang Z, Sonenshein GE, Rothstein TL. Maintenance of nuclear factor-κB/Rel and c-myc expression during CD40 ligand rescue of WEHI 231 early B cells from receptor-mediated apoptosis through modulation of IκB proteins. J Immunol 1996; 157:81-6.
    • (1996) J Immunol , vol.157 , pp. 81-86
    • Schauer, S.L.1    Wang, Z.2    Sonenshein, G.E.3    Rothstein, T.L.4
  • 36
    • 0030061131 scopus 로고    scopus 로고
    • CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype
    • Galibert L, Burdin N, de Saint-Vis B, et al. CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype. J Exp Med 1996;183:77-85.
    • (1996) J Exp Med , vol.183 , pp. 77-85
    • Galibert, L.1    Burdin, N.2    de Saint-Vis, B.3
  • 37
    • 0031043509 scopus 로고    scopus 로고
    • Telomerase activity is induced in human peripheral B lymphocytes by the stimulation to antigen receptor
    • Igarashi H, Sakaguchi N. Telomerase activity is induced in human peripheral B lymphocytes by the stimulation to antigen receptor. Blood 1997;89: 1299-307.
    • (1997) Blood , vol.89 , pp. 1299-1307
    • Igarashi, H.1    Sakaguchi, N.2
  • 38
    • 0028265454 scopus 로고
    • Inhibition of human B-cell lymphoma growth by CD40 stimulation
    • Funakoshi S, Longo DL, Beckwith M, et al. Inhibition of human B-cell lymphoma growth by CD40 stimulation. Blood 1994;83:2787-94.
    • (1994) Blood , vol.83 , pp. 2787-2794
    • Funakoshi, S.1    Longo, D.L.2    Beckwith, M.3
  • 39
    • 0030067795 scopus 로고    scopus 로고
    • A novel function of CD40: Induction of cell death in transformed cells
    • Hess S, Engelmann H. A novel function of CD40: induction of cell death in transformed cells. J Exp Med 1996;183:159-67.
    • (1996) J Exp Med , vol.183 , pp. 159-167
    • Hess, S.1    Engelmann, H.2
  • 40
    • 10544246075 scopus 로고    scopus 로고
    • CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr Virus-encoded LMP1: Involvement of TRAF3 as a common mediator
    • Eliopoulos AG, Dawson CW, Mosialos G, et al. CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr Virus-encoded LMP1: involvement of TRAF3 as a common mediator. Oncogene 1996;13:2243-54.
    • (1996) Oncogene , vol.13 , pp. 2243-2254
    • Eliopoulos, A.G.1    Dawson, C.W.2    Mosialos, G.3
  • 41
    • 0033559616 scopus 로고    scopus 로고
    • Stimulation of CD40 on immunogenic human malignant melanomas augments their cytotoxic T lymphocyte-mediated lysis and induces apoptosis
    • von Leoprechting A, van der Bruggen P, Pahl HL, Aruffo A, Simon JC. Stimulation of CD40 on immunogenic human malignant melanomas augments their cytotoxic T lymphocyte-mediated lysis and induces apoptosis. Cancer Res 1999;59:1287-94.
    • (1999) Cancer Res , vol.59 , pp. 1287-1294
    • von Leoprechting, A.1    van der Bruggen, P.2    Pahl, H.L.3    Aruffo, A.4    Simon, J.C.5
  • 42
    • 0033135236 scopus 로고    scopus 로고
    • Inhibition of human breast carcinoma growth by a soluble recombinant human CD40 ligand
    • Hirano A, Longo DL, Taub DD, et al. Inhibition of human breast carcinoma growth by a soluble recombinant human CD40 ligand. Blood 1999;93: 2999-3007.
    • (1999) Blood , vol.93 , pp. 2999-3007
    • Hirano, A.1    Longo, D.L.2    Taub, D.D.3
  • 43
    • 0035886792 scopus 로고    scopus 로고
    • Recombinant CD40 ligand therapy has significant antitumor effects on CD40-positive ovarian tumor xenografts grown in SCID mice and demonstrates an augmented effect with cisplatin
    • Ghamande S, Hylander BL, Oflazoglu E, Lele S, Fanslow W, Repasky EA. Recombinant CD40 ligand therapy has significant antitumor effects on CD40-positive ovarian tumor xenografts grown in SCID mice and demonstrates an augmented effect with cisplatin. Cancer Res 2001;61:7556-62.
    • (2001) Cancer Res , vol.61 , pp. 7556-7562
    • Ghamande, S.1    Hylander, B.L.2    Oflazoglu, E.3    Lele, S.4    Fanslow, W.5    Repasky, E.A.6
  • 44
    • 0029835904 scopus 로고    scopus 로고
    • CD40 is a prognostic marker in primary cutaneous malignant melanoma
    • van den Oord JJ, Maes A, Stas M, et al. CD40 is a prognostic marker in primary cutaneous malignant melanoma. Am J Pathol 1996;149:1953-61.
    • (1996) Am J Pathol , vol.149 , pp. 1953-1961
    • van den Oord, J.J.1    Maes, A.2    Stas, M.3
  • 45
    • 0042591416 scopus 로고    scopus 로고
    • Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors
    • Nowak AK, Robinson BW, Lake RA. Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors. Cancer Res 2003;63:4490-6.
    • (2003) Cancer Res , vol.63 , pp. 4490-4496
    • Nowak, A.K.1    Robinson, B.W.2    Lake, R.A.3
  • 46
    • 0035397985 scopus 로고    scopus 로고
    • Phase I study of recombinant human CD40 ligand in cancer patients
    • Vonderheide RH, Dutcher JP, Anderson JE, et al. Phase I study of recombinant human CD40 ligand in cancer patients. J Clin Oncol 2001;19:3280-7.
    • (2001) J Clin Oncol , vol.19 , pp. 3280-3287
    • Vonderheide, R.H.1    Dutcher, J.P.2    Anderson, J.E.3
  • 47
    • 33947251868 scopus 로고    scopus 로고
    • In vivo efficacy of the CD40 agonist antibody CP-870,893 against a broad range of tumor types: Impact of tumor CD40 expression, dendritic cells, and chemotherapy
    • 103s
    • Gladue R, Cole S, Donovan C, et al. In vivo efficacy of the CD40 agonist antibody CP-870,893 against a broad range of tumor types: impact of tumor CD40 expression, dendritic cells, and chemotherapy. J Clin Oncol 2006;24:103s.
    • (2006) J Clin Oncol , vol.24
    • Gladue, R.1    Cole, S.2    Donovan, C.3
  • 48
    • 33947260196 scopus 로고    scopus 로고
    • In vitro characterization and pre-clinical pharmacokinetics of CP-870,893, a human anti-CD40 agonist antibody
    • 109s
    • Bedian V, Donovan C, Garder J, et al. In vitro characterization and pre-clinical pharmacokinetics of CP-870,893, a human anti-CD40 agonist antibody. J Clin Oncol 2006;24:109s.
    • (2006) J Clin Oncol , vol.24
    • Bedian, V.1    Donovan, C.2    Garder, J.3
  • 49
    • 33947506186 scopus 로고    scopus 로고
    • Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody
    • in press
    • Vonderheide RH, Flaherty KT, Khalil M, et al. Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody. J Clin Oncol 2007, in press.
    • (2007) J Clin Oncol
    • Vonderheide, R.H.1    Flaherty, K.T.2    Khalil, M.3
  • 50
    • 24944581157 scopus 로고    scopus 로고
    • Preclinical anti-lymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40
    • Law CL, Gordon KA, Collier J, et al. Preclinical anti-lymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40. Cancer Res 2005;65: 8331-8.
    • (2005) Cancer Res , vol.65 , pp. 8331-8338
    • Law, C.L.1    Gordon, K.A.2    Collier, J.3
  • 51
    • 6944247322 scopus 로고    scopus 로고
    • Mechanisms by which SGN-40, a humanized anti-CD40 antibody, induces cytotoxicity in human multiple myeloma cells: Clinical implications
    • Tai YT, Catley LP, Mitsiades CS, et al. Mechanisms by which SGN-40, a humanized anti-CD40 antibody, induces cytotoxicity in human multiple myeloma cells: clinical implications. Cancer Res 2004;64:2846-52.
    • (2004) Cancer Res , vol.64 , pp. 2846-2852
    • Tai, Y.T.1    Catley, L.P.2    Mitsiades, C.S.3
  • 52
    • 33747104543 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics, pharmacodynamics, and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates
    • Kelley SK, Gelzleichter T, Xie D, et al. Preclinical pharmacokinetics, pharmacodynamics, and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates. Br J Pharmacol 2006;148:1116-23.
    • (2006) Br J Pharmacol , vol.148 , pp. 1116-1123
    • Kelley, S.K.1    Gelzleichter, T.2    Xie, D.3
  • 53
    • 33947419944 scopus 로고    scopus 로고
    • A humanized antibody against CD40 (SGN-40) is well tolerated and active in non-Hodgkin's lymphoma (NHL): Results of a phase 1 study
    • 430s
    • Forero-Torres A, Furman RR, Rosenblatt JD, Younes A, Harrop K, Drachman JG. A humanized antibody against CD40 (SGN-40) is well tolerated and active in non-Hodgkin's lymphoma (NHL): results of a phase 1 study. J Clin Oncol 2006;24:430s.
    • (2006) J Clin Oncol , vol.24
    • Forero-Torres, A.1    Furman, R.R.2    Rosenblatt, J.D.3    Younes, A.4    Harrop, K.5    Drachman, J.G.6
  • 54
    • 33646250289 scopus 로고    scopus 로고
    • A phase I humanized anti-CD40 monoclonal antibody (SGN-40) in patients with multiple myeloma [abstract 2572]
    • Hussein MA, Berenson JR, Niesvizky R, et al. A phase I humanized anti-CD40 monoclonal antibody (SGN-40) in patients with multiple myeloma [abstract 2572]. Blood 2005;106.
    • (2005) Blood , pp. 106
    • Hussein, M.A.1    Berenson, J.R.2    Niesvizky, R.3
  • 55
    • 33947221616 scopus 로고    scopus 로고
    • In vitro activity of a novel fully human anti-CD40 antibody CHIR-12.12 in chronic lymphocytic leukemia: Blockade of CD40 activation and induction of ADCC [abstract 2504]
    • Tong X, Georgakis GV, Long L, O'Brien S, Younes A, Luqman M. In vitro activity of a novel fully human anti-CD40 antibody CHIR-12.12 in chronic lymphocytic leukemia: blockade of CD40 activation and induction of ADCC [abstract 2504]. Blood 2005;106.
    • (2005) Blood , pp. 106
    • Tong, X.1    Georgakis, G.V.2    Long, L.3    O'Brien, S.4    Younes, A.5    Luqman, M.6
  • 56
    • 0029115616 scopus 로고
    • Follicular lymphomas can be induced to present alloantigen efficiently: A conceptual model to improve their tumor immunogenicity
    • Schultze JL, Cardoso AA, Freeman GJ, et al. Follicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity. Proc Natl Acad Sci U S A 1995;92:8200-4.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 8200-8204
    • Schultze, J.L.1    Cardoso, A.A.2    Freeman, G.J.3
  • 58
    • 32644436462 scopus 로고    scopus 로고
    • Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and allogeneic stem cell transplantation
    • Rousseau RF, Biagi E, Dutour A, et al. Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and allogeneic stem cell transplantation. Blood 2006; 107:1332-41.
    • (2006) Blood , vol.107 , pp. 1332-1341
    • Rousseau, R.F.1    Biagi, E.2    Dutour, A.3
  • 59
    • 0031469361 scopus 로고    scopus 로고
    • CD40 activated human B cells: An alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapy
    • Schultze JL, Michalak S, Seamon MJ, et al. CD40 activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapy. J Clin Invest 1997;100:2757-65.
    • (1997) J Clin Invest , vol.100 , pp. 2757-2765
    • Schultze, J.L.1    Michalak, S.2    Seamon, M.J.3
  • 60
    • 1542343957 scopus 로고    scopus 로고
    • RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: Implications for pediatric immunotherapy
    • Coughlin CM, Vance BA, Grupp SA, Vonderheide RH. RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: implications for pediatric immunotherapy. Blood 2004;103:2046-54.
    • (2004) Blood , vol.103 , pp. 2046-2054
    • Coughlin, C.M.1    Vance, B.A.2    Grupp, S.A.3    Vonderheide, R.H.4
  • 61
    • 0033539302 scopus 로고    scopus 로고
    • A stimulating new target for cancer immunotherapy
    • Schultze J, Johnson P. A stimulating new target for cancer immunotherapy. Lancet 1999;354:1225-7.
    • (1999) Lancet , vol.354 , pp. 1225-1227
    • Schultze, J.1    Johnson, P.2
  • 62
    • 0037277480 scopus 로고    scopus 로고
    • Prospects for CD40-directed experimental therapy of human cancer
    • Tong AW, Stone MJ. Prospects for CD40-directed experimental therapy of human cancer. Cancer Gene Ther 2003;10:1-13.
    • (2003) Cancer Gene Ther , vol.10 , pp. 1-13
    • Tong, A.W.1    Stone, M.J.2
  • 63
    • 33644798247 scopus 로고    scopus 로고
    • CTLA-4 blockade: Autoimmunity as treatment
    • Kapadia D, Fong L. CTLA-4 blockade: autoimmunity as treatment. J Clin Oncol 2005;23:8926-8.
    • (2005) J Clin Oncol , vol.23 , pp. 8926-8928
    • Kapadia, D.1    Fong, L.2
  • 65
  • 66
    • 33744987907 scopus 로고    scopus 로고
    • Eradication of established tumors in mice by a combination antibody-based therapy
    • Uno T, Takeda K, Kojima Y, et al. Eradication of established tumors in mice by a combination antibody-based therapy. Nat Med 2006;12:693-8.
    • (2006) Nat Med , vol.12 , pp. 693-698
    • Uno, T.1    Takeda, K.2    Kojima, Y.3
  • 67
    • 0036173059 scopus 로고    scopus 로고
    • A CD40 signalosome anchored in lipid rafts leads to constitutive activation of NF-κB and autonomous cell growth in B cell lymphomas
    • Pham LV, Tamayo AT, Yoshimura LC, et al. A CD40 signalosome anchored in lipid rafts leads to constitutive activation of NF-κB and autonomous cell growth in B cell lymphomas. Immunity 2002;16:37-50.
    • (2002) Immunity , vol.16 , pp. 37-50
    • Pham, L.V.1    Tamayo, A.T.2    Yoshimura, L.C.3
  • 69
    • 0038658816 scopus 로고    scopus 로고
    • The CD40-154 interaction in B cell-T cell liaisons
    • Bishop GA, Hostager BS. The CD40-154 interaction in B cell-T cell liaisons. Cytokine Growth Factor Rev 2003;14:297-309.
    • (2003) Cytokine Growth Factor Rev , vol.14 , pp. 297-309
    • Bishop, G.A.1    Hostager, B.S.2
  • 70
    • 0034644474 scopus 로고    scopus 로고
    • Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
    • Deng L, Wang C, Spencer E, et al. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 2000;103:351-61.
    • (2000) Cell , vol.103 , pp. 351-361
    • Deng, L.1    Wang, C.2    Spencer, E.3
  • 72
    • 0033151951 scopus 로고    scopus 로고
    • Cutting edge: Contrasting roles of TNF receptor-associated factor 2 (TRAF2) and TRAF3 in CD40-activated B lymphocyte differentiation
    • Hostager BS, Bishop GA. Cutting edge: contrasting roles of TNF receptor-associated factor 2 (TRAF2) and TRAF3 in CD40-activated B lymphocyte differentiation. J Immunol 1999;162:6307-11.
    • (1999) J Immunol , vol.162 , pp. 6307-6311
    • Hostager, B.S.1    Bishop, G.A.2
  • 73
    • 0030917141 scopus 로고    scopus 로고
    • Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells
    • Hanissian SH, Geha RS. Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells. Immunity 1997;6:379-87.
    • (1997) Immunity , vol.6 , pp. 379-387
    • Hanissian, S.H.1    Geha, R.S.2
  • 74
    • 0027979446 scopus 로고
    • Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase Cγ2
    • Ren CL, Morio T, Fu SM, Geha RS. Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase Cγ2. J Exp Med 1994;179:673-80.
    • (1994) J Exp Med , vol.179 , pp. 673-680
    • Ren, C.L.1    Morio, T.2    Fu, S.M.3    Geha, R.S.4
  • 75
    • 0033556333 scopus 로고    scopus 로고
    • Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α
    • Fruman DA, Snapper SB, Yballe CM, et al. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α. Science 1999;283: 393-7.
    • (1999) Science , vol.283 , pp. 393-397
    • Fruman, D.A.1    Snapper, S.B.2    Yballe, C.M.3
  • 76
    • 0033555829 scopus 로고    scopus 로고
    • Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase
    • Suzuki H, Terauchi Y, Fujiwara M, et al. Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase. Science 1999;283:390-2.
    • (1999) Science , vol.283 , pp. 390-392
    • Suzuki, H.1    Terauchi, Y.2    Fujiwara, M.3
  • 77
    • 33947236920 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics from a first-in-human phase 1 dose escalation study with antagonist anti-CD40 antibody, HCD 122 (formerly CHIR-12.12), in patients with relapsed and refractory chronic lymphocytic leukemia [abstract 2837]
    • Byrd JC, Flinn IW, Khan KD, et al. Pharmacokinetics and pharmacodynamics from a first-in-human phase 1 dose escalation study with antagonist anti-CD40 antibody, HCD 122 (formerly CHIR-12.12), in patients with relapsed and refractory chronic lymphocytic leukemia [abstract 2837]. Blood 2006;108.
    • (2006) Blood , pp. 108
    • Byrd, J.C.1    Flinn, I.W.2    Khan, K.D.3
  • 78
    • 33947203349 scopus 로고    scopus 로고
    • A phase 1 dose escalation study of a fully human, antagonist anti-CD40 antibody, HCD 122 (formerly CHIR-12.12), in patients with relapsed and refractory multiple myeloma [abstract 3575]
    • Bensinger W, Jagannath S, Becker PS, et al. A phase 1 dose escalation study of a fully human, antagonist anti-CD40 antibody, HCD 122 (formerly CHIR-12.12), in patients with relapsed and refractory multiple myeloma [abstract 3575]. Blood 2006;108.
    • (2006) Blood , pp. 108
    • Bensinger, W.1    Jagannath, S.2    Becker, P.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.