메뉴 건너뛰기




Volumn 164, Issue 10, 2000, Pages 5319-5327

Structural analysis of CTLA-4 function in vivo

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

EID: 0034658408     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.10.5319     Document Type: Article
Times cited : (212)

References (50)
  • 1
    • 0030694234 scopus 로고    scopus 로고
    • The emerging role of CTLA-4 as an immune attenuator
    • Thompson, C. B., and J. P. Allison. 1997. The emerging role of CTLA-4 as an immune attenuator. Immunity 7:445.
    • (1997) Immunity , vol.7 , pp. 445
    • Thompson, C.B.1    Allison, J.P.2
  • 2
    • 0032931973 scopus 로고    scopus 로고
    • Costimulatory regulation of T cell function
    • Chambers, C. A., and J. P. Allison. 1999. Costimulatory regulation of T cell function. Curr. Opin. Cell Biol. 11:203.
    • (1999) Curr. Opin. Cell Biol. , vol.11 , pp. 203
    • Chambers, C.A.1    Allison, J.P.2
  • 4
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach, D. R., M. F. Krummel, and J. P. Allison. 1996. Enhancement of antitumor immunity by CTLA-4 blockade. Science 271:1734.
    • (1996) Science , vol.271 , pp. 1734
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 6
    • 0030853610 scopus 로고    scopus 로고
    • Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: The effect is manifested only at the restricted tumor-bearing stages
    • Yang, Y. F., J. P. Zou, J. Mu, R. Wijesuriya, S. Ono, T. Walunas, J. Bluestone, H. Fujiwara, and T. Hamaoka. 1997. Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: the effect is manifested only at the restricted tumor-bearing stages. Cancer Res. 57:4036.
    • (1997) Cancer Res. , vol.57 , pp. 4036
    • Yang, Y.F.1    Zou, J.P.2    Mu, J.3    Wijesuriya, R.4    Ono, S.5    Walunas, T.6    Bluestone, J.7    Fujiwara, H.8    Hamaoka, T.9
  • 7
    • 0032544067 scopus 로고    scopus 로고
    • CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
    • Hurwitz, A. A., T. F. Yu, D. R. Leach, and J. P. Allison. 1998. CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma. Proc. Natl. Acad. Sci. USA 95:10067.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10067
    • Hurwitz, A.A.1    Yu, T.F.2    Leach, D.R.3    Allison, J.P.4
  • 8
    • 0030872154 scopus 로고    scopus 로고
    • Protective immunity to nematode infection is induced by CTLA-4 blockade
    • McCoy, K., M. Camberis, and G. L. Gros. 1997. Protective immunity to nematode infection is induced by CTLA-4 blockade. J. Exp. Med. 186:183.
    • (1997) J. Exp. Med. , vol.186 , pp. 183
    • McCoy, K.1    Camberis, M.2    Gros, G.L.3
  • 9
    • 0032532640 scopus 로고    scopus 로고
    • Blockade of CTLA-4 enhances host resistance to the intracellular pathogen, Leishmania donovani
    • Murphy, M. L., S. E. Cotterell, P. M. Gorak, C. R. Engwerda, and P. M. Kaye. 1998. Blockade of CTLA-4 enhances host resistance to the intracellular pathogen, Leishmania donovani. J. Immunol. 161:4153.
    • (1998) J. Immunol. , vol.161 , pp. 4153
    • Murphy, M.L.1    Cotterell, S.E.2    Gorak, P.M.3    Engwerda, C.R.4    Kaye, P.M.5
  • 10
    • 0031739697 scopus 로고    scopus 로고
    • CTLA4 (CD152) modulates the Th subset response and alters the course of experimental Leishmania major infection
    • Saha, B., S. Chattopadhyay, R. Germond, D. M. Harlan, and P. J. Perrin. 1998. CTLA4 (CD152) modulates the Th subset response and alters the course of experimental Leishmania major infection. Eur. J. Immunol. 28:4213.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 4213
    • Saha, B.1    Chattopadhyay, S.2    Germond, R.3    Harlan, D.M.4    Perrin, P.J.5
  • 11
    • 0033517152 scopus 로고    scopus 로고
    • Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
    • van Elsas, A., A. A. Hurwitz, and J. P. Allison. 1999. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J. Exp. Med. 190:355.
    • (1999) J. Exp. Med. , vol.190 , pp. 355
    • Van Elsas, A.1    Hurwitz, A.A.2    Allison, J.P.3
  • 13
    • 0030586626 scopus 로고    scopus 로고
    • CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis
    • Perrin, P. J., J. H. Maldonado, T. A. Davis, C. H. June, and M. K. Racke. 1996. CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis. J. Immunol. 157:1333.
    • (1996) J. Immunol. , vol.157 , pp. 1333
    • Perrin, P.J.1    Maldonado, J.H.2    Davis, T.A.3    June, C.H.4    Racke, M.K.5
  • 14
    • 2642655282 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes
    • Luhder, F., P. Hoglund, J. P. Allison, C. Benoist, and D. Mathis. 1998. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J. Exp. Med. 187:427.
    • (1998) J. Exp. Med. , vol.187 , pp. 427
    • Luhder, F.1    Hoglund, P.2    Allison, J.P.3    Benoist, C.4    Mathis, D.5
  • 15
    • 0032490620 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28
    • Lin, H., J. C. Rathmell, G. S. Gray, C. B. Thompson, J. M. Leiden, and M. L. Alegre. 1998. Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. J. Exp. Med. 188:199.
    • (1998) J. Exp. Med. , vol.188 , pp. 199
    • Lin, H.1    Rathmell, J.C.2    Gray, G.S.3    Thompson, C.B.4    Leiden, J.M.5    Alegre, M.L.6
  • 16
    • 0032080384 scopus 로고    scopus 로고
    • Involvement of CD40 ligand-CD40 and CTLA4-B7 pathways in murine acute graft-versus-host disease induced by allogeneic T cells lacking CD28
    • Saito, K., J. Sakurai, J. Ohata, T. Kohsaka, H. Hashimoto, K. Okumura, R. Abe, and M. Azuma. 1998. Involvement of CD40 ligand-CD40 and CTLA4-B7 pathways in murine acute graft-versus-host disease induced by allogeneic T cells lacking CD28. J. Immunol. 160:4225.
    • (1998) J. Immunol. , vol.160 , pp. 4225
    • Saito, K.1    Sakurai, J.2    Ohata, J.3    Kohsaka, T.4    Hashimoto, H.5    Okumura, K.6    Abe, R.7    Azuma, M.8
  • 18
    • 0032522488 scopus 로고    scopus 로고
    • CTLA-4 regulates tolerance induction and T cell differentiation in vivo
    • Walunas, T. L., and J. A. Bluestone. 1998. CTLA-4 regulates tolerance induction and T cell differentiation in vivo. J. Immunol. 160:3855.
    • (1998) J. Immunol. , vol.160 , pp. 3855
    • Walunas, T.L.1    Bluestone, J.A.2
  • 20
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol, E. A., F. Borriello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone, and A. H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3:541.
    • (1995) Immunity , vol.3 , pp. 541
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 22
    • 0030740572 scopus 로고    scopus 로고
    • Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice
    • Waterhouse, P., M. F. Bachmann, J. M. Penninger, P. S. Ohashi, and T. W. Mak. 1997. Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice. Eur. J. Immunol. 27: 1887.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 1887
    • Waterhouse, P.1    Bachmann, M.F.2    Penninger, J.M.3    Ohashi, P.S.4    Mak, T.W.5
  • 24
    • 0031154577 scopus 로고    scopus 로고
    • CTLA41g prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice
    • Tivol, E. A., S. D. Boyd, S. McKeon, F. Borriello, P. Nickerson, T. B. Strom, and A. H. Sharpe. 1997. CTLA41g prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice. J. Immunol. 158:5091.
    • (1997) J. Immunol. , vol.158 , pp. 5091
    • Tivol, E.A.1    Boyd, S.D.2    McKeon, S.3    Borriello, F.4    Nickerson, P.5    Strom, T.B.6    Sharpe, A.H.7
  • 25
    • 0033579816 scopus 로고    scopus 로고
    • B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
    • Mandelbrot, D. A., A. J. McAdam, and A. H. Sharpe. 1999. B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). J. Exp. Med. 189:435.
    • (1999) J. Exp. Med. , vol.189 , pp. 435
    • Mandelbrot, D.A.1    McAdam, A.J.2    Sharpe, A.H.3
  • 26
    • 0344299189 scopus 로고    scopus 로고
    • Cutting edge: Lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous
    • Bachmann, M. F., G. Kohler, B. Ecabert, T. W. Mak, and M. Kopf. 1999. Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous. J. Immunol. 163:1128.
    • (1999) J. Immunol. , vol.163 , pp. 1128
    • Bachmann, M.F.1    Kohler, G.2    Ecabert, B.3    Mak, T.W.4    Kopf, M.5
  • 28
    • 0028675006 scopus 로고
    • Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
    • Linsley, P. S., J. L. Greene, W. Brady, J. Bajorath, J. A. Ledbetter, and R. Peach. 1994. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1:793.
    • (1994) Immunity , vol.1 , pp. 793
    • Linsley, P.S.1    Greene, J.L.2    Brady, W.3    Bajorath, J.4    Ledbetter, J.A.5    Peach, R.6
  • 29
    • 0031054242 scopus 로고    scopus 로고
    • CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics
    • van der Merwe, P. A., D. L. Bodian, S. Daenke, P. Linsley, and S. J. Davis. 1997. CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. J. Exp. Med. 185:393.
    • (1997) J. Exp. Med. , vol.185 , pp. 393
    • Van Der Merwe, P.A.1    Bodian, D.L.2    Daenke, S.3    Linsley, P.4    Davis, S.J.5
  • 30
    • 0028910221 scopus 로고
    • CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
    • Schneider, H., K. V. Prasad, S. E. Shoelson, and C. E. Rudd. 1995. CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells. J. Exp. Med. 181:351.
    • (1995) J. Exp. Med. , vol.181 , pp. 351
    • Schneider, H.1    Prasad, K.V.2    Shoelson, S.E.3    Rudd, C.E.4
  • 31
    • 0030707866 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor ζ and ZAP70
    • Calvo, C. R., D. Amsen, and A. M. Kruisbeek. 1997. Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor ζ and ZAP70. J. Exp. Med. 186:1645.
    • (1997) J. Exp. Med. , vol.186 , pp. 1645
    • Calvo, C.R.1    Amsen, D.2    Kruisbeek, A.M.3
  • 33
    • 0030001318 scopus 로고    scopus 로고
    • Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4
    • Marengere, L. E., P. Waterhouse, G. S. Duncan, H. W. Mittrucker, G. S. Feng, and T. W. Mak. 1996. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272:1170.
    • (1996) Science , vol.272 , pp. 1170
    • Marengere, L.E.1    Waterhouse, P.2    Duncan, G.S.3    Mittrucker, H.W.4    Feng, G.S.5    Mak, T.W.6
  • 34
    • 0028852073 scopus 로고
    • Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail
    • Leung, H. T., J. Bradshaw, J. S. Cleaveland, and P. S. Linsley. 1995. Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail. J. Biol. Chem. 270:25107.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25107
    • Leung, H.T.1    Bradshaw, J.2    Cleaveland, J.S.3    Linsley, P.S.4
  • 35
    • 0030176371 scopus 로고    scopus 로고
    • Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement
    • Linsley, P. S., J. Bradshaw, J. Greene, R. Peach, K. L. Bennett, and R. S. Mittler. 1996. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 4:535.
    • (1996) Immunity , vol.4 , pp. 535
    • Linsley, P.S.1    Bradshaw, J.2    Greene, J.3    Peach, R.4    Bennett, K.L.5    Mittler, R.S.6
  • 37
    • 0033567050 scopus 로고    scopus 로고
    • Cytolytic T lymphocyte-associated antigen-4 and the TCRζ/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2
    • Schneider, H., M. Martin, F. A. Agarraberes, L. Yin, I. Rapoport, T. Kirchhausen, and C. E. Rudd. 1999. Cytolytic T lymphocyte-associated antigen-4 and the TCRζ/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2. J. Immunol. 163:1868.
    • (1999) J. Immunol. , vol.163 , pp. 1868
    • Schneider, H.1    Martin, M.2    Agarraberes, F.A.3    Yin, L.4    Rapoport, I.5    Kirchhausen, T.6    Rudd, C.E.7
  • 38
    • 0031181647 scopus 로고    scopus 로고
    • Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression
    • Chuang, E., M. L. Alegre, C. S. Duckett, P. J. Noel, M. G. Vander Heiden, and C. B. Thompson. 1997. Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. J. Immunol. 159:144.
    • (1997) J. Immunol. , vol.159 , pp. 144
    • Chuang, E.1    Alegre, M.L.2    Duckett, C.S.3    Noel, P.J.4    Vander Heiden, M.G.5    Thompson, C.B.6
  • 39
    • 0030917081 scopus 로고    scopus 로고
    • Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP- 2
    • Shiratori, T., S. Miyatake, H. Ohno, C. Nakaseko, K. Isono, J. S. Bonifacino, and T. Saito. 1997. Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP- 2. Immunity 6:583.
    • (1997) Immunity , vol.6 , pp. 583
    • Shiratori, T.1    Miyatake, S.2    Ohno, H.3    Nakaseko, C.4    Isono, K.5    Bonifacino, J.S.6    Saito, T.7
  • 40
    • 0030611358 scopus 로고    scopus 로고
    • Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
    • Zhang, Y., and J. P. Allison. 1997. Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. Proc. Natl. Acad. Sci. USA 94:9273.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9273
    • Zhang, Y.1    Allison, J.P.2
  • 41
    • 0031471027 scopus 로고    scopus 로고
    • Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation
    • Bradshaw, J. D., P. Lu, G. Leytze, J. Rodgers, G. L. Schieven, K L. Bennett, P. S. Linsley, and S-E. Kurtz. 1997. Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation. Biochemistry 36:15975.
    • (1997) Biochemistry , vol.36 , pp. 15975
    • Bradshaw, J.D.1    Lu, P.2    Leytze, G.3    Rodgers, J.4    Schieven, G.L.5    Bennett, K.L.6    Linsley, P.S.7    Kurtz, S.-E.8
  • 43
  • 44
    • 0025025955 scopus 로고
    • A 3′ transcriptional enhancer regulates tissue-specific expression of the human CD2 gene
    • Lake, R. A., D. Wotton, and M. J. Owen. 1990. A 3′ transcriptional enhancer regulates tissue-specific expression of the human CD2 gene. EMBO J. 9:3129.
    • (1990) EMBO J. , vol.9 , pp. 3129
    • Lake, R.A.1    Wotton, D.2    Owen, M.J.3
  • 46
    • 0028933795 scopus 로고
    • The regulation of immunity to Leishmania major
    • Reiner, S. L., and R. M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 151
    • Reiner, S.L.1    Locksley, R.M.2
  • 47
    • 0033563265 scopus 로고    scopus 로고
    • Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses
    • Khattri, R., J. A. Auger, M. D. Griffin, A. H. Sharpe, and J. A. Bluestone. 1999. Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses. J. Immunol. 162:5784.
    • (1999) J. Immunol. , vol.162 , pp. 5784
    • Khattri, R.1    Auger, J.A.2    Griffin, M.D.3    Sharpe, A.H.4    Bluestone, J.A.5
  • 49
    • 0032033419 scopus 로고    scopus 로고
    • Cytokines induce the development of functionally heterogeneous T helper cell subsets
    • O'Garra, A. 1998. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8:275.
    • (1998) Immunity , vol.8 , pp. 275
    • O'Garra, A.1
  • 50
    • 0033166538 scopus 로고    scopus 로고
    • Dealing from the evolutionary pawn shop: How lymphocytes make decisions
    • Reiner, S. L., and R. A. Seder. 1999. Dealing from the evolutionary pawn shop: how lymphocytes make decisions. Immunity 11:1.
    • (1999) Immunity , vol.11 , pp. 1
    • Reiner, S.L.1    Seder, R.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.