New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme Structural features of CYP2D6 B. Wang et al.

Drug Metabolism Reviews

Volumn 41, Issue 4, 2009, Pages 573-643

  Wang, Bo ^a   Yang, Li Ping ^b   Zhang, Xiao Zhuang ^a   Huang, Shui Qing ^a   Bartlam, Mark ^c   Zhou, Shu Feng ^d  

^a Guangdong Women and Childrens Hospital ^*  (China)

^b BEIJING HOSPITAL   (China)

^c NANKAI UNIVERSITY   (China)

^d RMIT UNIVERSITY   (Australia)

Author keywords

Active site; CYP2D6; Homology modeling; Pharmacophore; Site directed mutagenesis

Indexed keywords

1,2,3,4 TETRAHYDROQUINOLINE DERIVATIVE; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3 [2 (N,N DIETHYL N METHYLAMMONIUM)ETHYL] 7 METHOXY 4 METHYLCOUMARIN; ALKALOID; ALMOTRIPTAN; ANTIEMETIC AGENT; BUFURALOL; CARCINOGEN; CENTRAL NERVOUS SYSTEM AGENTS; CHOLESTEROL 7ALPHA MONOOXYGENASE; CIMETIDINE; COUMARIN DERIVATIVE; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DEBRISOQUINE; DEXTROMETHORPHAN; DEXTRORPHAN; NEUROLEPTIC AGENT; NEUROSTEROID; NEUROTOXIN; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; SPARTEINE; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

CLINICAL PRACTICE; CRYSTAL STRUCTURE; DRUG METABOLISM; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME POLYMORPHISM; ENZYME SPECIFICITY; EVOLUTIONARY HOMOLOGY; HUMAN; LIGAND BINDING; METABOLITE; MOLECULAR MODEL; NONHUMAN; OXIDATION; PH; PHARMACOPHORE; REVIEW; SITE DIRECTED MUTAGENESIS;

ANIMALS; BINDING SITES; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; METABOLIC DETOXICATION, DRUG; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 70350044889     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.1080/03602530903118729     Document Type: Review

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