Human liver mitochondrial cytochrome P450 2D6 - Individual variations and implications in drug metabolism

FEBS Journal

Volumn 276, Issue 13, 2009, Pages 3440-3453

  Sangar, Michelle Cook ^a   Anandatheerthavarada, Hindupur K ^a   Tang, Weigang ^a   Prabu, Subbuswamy K ^a   Martin, Martha V ^b   Dostalek, Miroslav ^b   Guengerich, F Peter ^b   Avadhani, Narayan G ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

Bimodal targeting signal; Bufuralol 1 hydroxylase; Human CYP2D6; Liver mitochondrial CYP2D6 content; Mitochondrial targeting

Indexed keywords

BUFURALOL; CYTOCHROME P450 2D6; PROADIFEN; QUINIDINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL STRAIN COS7; DRUG METABOLISM; ENDOPLASMIC RETICULUM; GENE DELETION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIVER MICROSOME; LIVER MITOCHONDRION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; COUMARINS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOCHROME P-450 CYP2D6; ETHANOLAMINES; HUMANS; ISOENZYMES; MICROSOMES, LIVER; MOLECULAR SEQUENCE DATA; PHARMACEUTICAL PREPARATIONS; PROTEIN SORTING SIGNALS;

EID: 67650474117     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2009.07067.x     Document Type: Article

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