The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-Å resolution

Journal of Biological Chemistry

Volumn 279, Issue 37, 2004, Pages 38091-38094

  Yano, Jason K ^a   Wester, Michael R ^a   Schoch, Guillaume A ^a   Griffin, Keith J ^a   Stout, C David ^a   Johnson, Eric F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CATALYSIS; CLINICAL LABORATORIES; DRUG INTERACTIONS; ENZYME INHIBITION; METABOLISM; OXIDATION; SUBSTRATES; X RAY CRYSTALLOGRAPHY;

CLINICAL DRUGS; CYTOCHROMES; SUBSTRATE OXIDATION;

CELLS;

ALPHA NAPHTHOFLAVONE; ANTIBIOTIC AGENT; CYCLOSPORIN; CYTOCHROME P450 2C8; CYTOCHROME P450 3A4; ERYTHROMYCIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MACROLIDE; TAXANE DERIVATIVE; TESTOSTERONE;

ARTICLE; CATALYSIS; CRYSTALLIZATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; MICROSOME; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ARGININE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; HEME; HUMANS; KINETICS; MICROSOMES; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

STAPHYLOCOCCUS PHAGE 3A;

EID: 4644301430     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C400293200     Document Type: Article

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