Enzymatic determinants of the substrate specificity of CYP2C9: Role of B'-C loop residues in providing the π-stacking anchor site for warfarin binding

Biochemistry

Volumn 38, Issue 11, 1999, Pages 3285-3292

  Haining, Robert L ^a   Jones, Jeffrey P ^b   Henne, Kirk R ^a   Fisher, Michael B ^a   Koop, Dennis R ^c   Trager, William F ^a   Rettie, Allan E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

WARFARIN;

ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME PURIFICATION; ENZYME SPECIFICITY; EPOXIDATION; HYDROPHOBICITY; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS;

ARACHIDONIC ACID; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; BLOTTING, WESTERN; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; DICLOFENAC; ELECTROSTATICS; KINETICS; LAURIC ACIDS; LEUCINE; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; PROTEIN STRUCTURE, SECONDARY; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY; SULFAPHENAZOLE; WARFARIN;

EID: 0033574258     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi982161+     Document Type: Article

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