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Volumn 41, Issue 36, 2002, Pages 11025-11034

Diversity in the oxidation of substrates by cytochrome P450 2D6: Lack of an obligatory role of aspartate 301-substrate electrostatic bonding

(11) Guengerich, F Peter a Yergey, James A d Nicoll Griffith, Deborah A d Miller, Grover P b Hanna, Imad H a,c Martin, Martha V a Léger, Serge d Black, Cameron d Chauret, Nathalie d Silva, José M d Trimble, Laird A d

a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE (United States)

b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES (United States)

c MERCK RESEARCH LABORATORIES (United States)

d MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROSTATIC INTERACTIONS;

AROMATIC COMPOUNDS; CATALYSIS; DRUG PRODUCTS; MUTAGENESIS; OXIDATION;

BIOCHEMISTRY;

4 [3 (4 FLUOROPHENYL) 2 OXO 1 OXASPIRO[4.4]NON 3 EN 4 YL]BENZENESULFONAMIDE; AMIDE; ASPARAGINE; ASPARTIC ACID; BUFURALOL; CARBENE; CYTOCHROME P450 2D6; DIMETHYL SULFONE; GLYCINE; HYDROGEN; LIGAND; NITROGEN; SERINE; SPIROSULFONAMIDE; SULFONAMIDE; THIOAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; ELECTRICITY; ENZYME SUBSTRATE; GENE MUTATION; HYDROGEN BOND; HYDROXYLATION; LIGAND BINDING; OXIDATION; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

AMINES; AMINO ACID SUBSTITUTION; ASPARTIC ACID; BACULOVIRIDAE; BINDING SITES; CATALYSIS; CYTOCHROME P-450 CYP2D6; ELECTROSTATICS; HUMANS; HYDROGEN BONDING; LIGANDS; MICROSOMES, LIVER; OXIDATION-REDUCTION; RECOMBINANT PROTEINS; SPIRO COMPOUNDS; SUBSTRATE SPECIFICITY; SULFONAMIDES;

CANIS;

EID: 0036712187 PISSN: 00062960 EISSN: None Source Type: Journal
DOI: 10.1021/bi020341k Document Type: Article

Times cited : (63)

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