Catalytic specificity of CYPD2D isoforms in rat and human

Drug Metabolism and Disposition

Volumn 30, Issue 9, 2002, Pages 970-976

  Hiroi, Toyoko ^a   Chow, Toshio ^a   Imaoka, Susumu ^a   Funae, Yoshihiko ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1' HYDROXYBUFURALOL; 1',2' ETHENYLBUFURALOL; 3 HYDROXYDEBRISOQUINE; 4 HYDROXYDEBRISOQUINE; BUFURALOL; CYTOCHROME P450; CYTOCHROME P450 2D; CYTOCHROME P450 2D1; CYTOCHROME P450 2D2; CYTOCHROME P450 2D3; CYTOCHROME P450 2D4; CYTOCHROME P450 2D6; DEBRISOQUINE; DRUG METABOLITE; PROPRANOLOL; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; ALCOHOL DEHYDROGENASE; CYP2D2 PROTEIN, RAT; CYP2D22 PROTEIN, RAT; CYP2D9 PROTEIN, RAT; ETHANOLAMINE DERIVATIVE; ISOENZYME; MIXED FUNCTION OXIDASE; RECOMBINANT PROTEIN; UNSPECIFIC MONOOXYGENASE;

ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG CONFORMATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE IDENTIFICATION; HUMAN; HUMAN TISSUE; HYDROXYLATION; LIVER METABOLISM; LIVER MICROSOME; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; ANIMAL; IN VITRO STUDY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANIMALIA; RODENTIA;

ALCOHOL OXIDOREDUCTASES; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CATALYSIS; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; DEBRISOQUIN; ETHANOLAMINES; HUMANS; ISOENZYMES; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; PROPRANOLOL; RATS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 0036707625     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.9.970     Document Type: Article

References (37)

1. Animal modelling of human polymorphic drug oxidation-the metabolism of debrisoquine and phenacetin in rat inbred strains
2. CYP2D6 mRNA expression in circulating peripheral blood mononuclear cells correlates with in vivo debrisoquine hydroxylase activity in extensive metabolizers
3. Developmental changes in the catalytic activity and expression of CYP2D isoforms in the rat liver
4. The genetic polymorphism of debrisoquine/sparteine metabolism-clinical aspects
5. 1- and 3-Hydroxylations, in addition to 4-hydroxylation, of debrisoquine are catalyzed by cytochrome P450 2D6 in humans
6. Regio- and stereoselective propranolol metabolism by 15 forms of purified cytochromes P-450 from rat liver
7. Simultaneous purification of multiple forms of rat liver microsomal cytochrome P-450 by high-performance liquid chromatography
8. Purification and characterization of liver microsomal cytochrome P-450 from untreated male rats
9. Purification and characterization of diabetes-inducible cytochrome P-450
10. The CYP2D subfamily
11. Debrisoquine 4-hydroxylase: Characterization of a new P450 gene subfamily, regulation, chromosomal mapping and molecular analysis of the DA rat polymorphism
12. Evidence for CYP2D6 expression in human lung
13. Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy
14. Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity
15. Developmental and endocrine regulation of P450 isoforms in rat breast
16. Tissue distributions of CYP2D1, 2D2, 2D3 and 2D4 mRNA in rats detected by RT-PCR
17. Alternative splicing of CYP2D mRNA in human breast tissue
18. Multiple forms of human P450 expressed in Saccharomyces cerevisiae. Systematic characterization and comparison with those of the rat
19. cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily
20. A novel P450 expressed at the high level in rat brain
21. Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase
22. Regioselective contribution of the cytochrome P-450 2D subfamily to propranolol metabolism in rat liver microsomes
23. Characterization of the oxidation reactions catalyzed by CYP2D enzyme in rat renal microsomes
24. The CYP2D gene subfamily: Analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats
25. max of the enzyme for bufuralol but not debrisoquine hydroxylation
26. Differential roles of cytochromes P450 2D1, 2C11 and 1A1/2 in the hydroxylation of bufuralol by rat liver microsomes
27. P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
28. 3H]GBR-12935 binding proteins
29. Characterization of two P-450 isozymes placed in the rat CYP2D subfamily
30. Competitive inhibition of sparteine oxidation in human liver by beta-adrenoceptor antagonists and other cardiovascular drugs
31. Correlation of polymorphic expression of CYP2D6 mRNA in bladder mucosa and tumor tissue to in vivo debrisoquine hydroxylase activity
32. Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae and their catalytic specificity
33. Debrisoquin hydroxylation polymorphism among Ghanaians and Caucasians
34. Molecular basis of the Dark Agouti rat drug oxidation polymorphism: Importance of CYP2D1 and CYP2D2
35. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes
36. Identification of human CYP isoforms involved in the metabolism of propanolol enantiomers-N-desisopropylation is mediated mainly by CYP1A2
37. Characterization of rat small intestinal cytochrome P450 composition and inducibility