Effect of carbonate anion on cytochrome P450 2D6-mediated metabolism in vitro: The potential role of multiple oxygenating species

Archives of Biochemistry and Biophysics

Volumn 417, Issue 2, 2003, Pages 165-175

  Hutzler, J Matthew ^a   Powers, Frank J ^a   Wynalda, Michael A ^a   Wienkers, Larry C ^a  

^a PFIZER INC   (United States)

Author keywords

Activated oxygen; Anion; Buffer; Carbonate; Cytochrome P450 2D6; Dextromethorphan; O dealkylation

Indexed keywords

3 [3 (METHYLSULFONYL)PHENYL] 1 PROPYLPIPERIDINE; ACETIC ACID; AMITRIPTYLINE; BUFFER; CARBONIC ACID; COUMARIN DERIVATIVE; CUMENE HYDROPEROXIDE; CYTOCHROME P450; DEXTROMETHORPHAN; OXYGEN; PHOSPHATE; SULFATE;

ARTICLE; DEALKYLATION; ENZYME METABOLISM; IN VITRO STUDY; KINETICS; PH; PRIORITY JOURNAL;

EID: 0042664035     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-9861(03)00350-3     Document Type: Article

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