Novel reversible inactivation of cytochrome P450 2E1 T303A by tert-butyl acetylene: The role of threonine 303 in proton delivery to the active site of cytochrome P450 2E1

Journal of Pharmacology and Experimental Therapeutics

Volumn 310, Issue 1, 2004, Pages 281-290

  Blobaum, Anna L ^a   Kent, Ute M ^a   Alworth, William L ^b   Hollenberg, Paul F ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b Tulane University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLENE DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 2E1; CYTOCHROME P450 2E1 T303A; CYTOCHROME P450 HEME; HEME DERIVATIVE; PROTON; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TERT BUTYL ACETYLENE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DNA ADDUCT; DOSE TIME EFFECT RELATION; DRUG MECHANISM; ELECTROSPRAY IONIZATION LIQUID CHROMATOGRAPHY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME KINETICS; ENZYME METABOLISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; GEL FILTRATION; INCUBATION TIME; ION FRAGMENTATION; ION TRANSPORT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTON TRANSPORT; RABBIT; TANDEM MASS SPECTROMETRY;

ACETYLENE; ALANINE; ALKYNES; ANIMALS; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2E1; ENZYME INHIBITORS; MUTATION; PROTONS; RABBITS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THREONINE;

EID: 3042593022     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.065508     Document Type: Article

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