Influence of n-substitution of 7-methoxy-4-(aminomethyl)-coumarin on cytochrome p450 metabolism and selectivity

Drug Metabolism and Disposition

Volumn 28, Issue 12, 2000, Pages 1524-1532

  Venhorst, Jennifer ^a   Onderwater, Rob C A ^a   Meerman, John H N ^a   Commandeur, Jan N M ^a   Vermeulen, Nico P E ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

7 METHOXY 4 AMINOMETHYLCOUMARIN; COUMARIN DERIVATIVE; CYTOCHROME P450 1A2; CYTOCHROME P450 2D6; CYTOCHROME P450 ISOENZYME; DEXTROMETHORPHAN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DEALKYLATION; DEMETHYLATION; DRUG METABOLISM; DRUG STRUCTURE; ENZYME KINETICS; ENZYME METABOLISM; HUMAN; LIVER MICROSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALKYLATION; BINDING, COMPETITIVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARINS; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; DEALKYLATION; HUMANS; HYDROXYLATION; ISOENZYMES; KINETICS; MICROSOMES, LIVER; MODELS, BIOLOGICAL; PROTEIN CONFORMATION; PROTEINS;

EID: 0033669346     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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