Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: A new high affinity and turnover enzyme-specific probe substrate

Journal of Pharmacology and Experimental Therapeutics

Volumn 300, Issue 2, 2002, Pages 399-407

  Li, Xue Qing ^a,b   Björkman, Anders ^b   Andersson, Tommy B ^a   Ridderström, Marianne ^a   Masimirembwa, Collen M ^a,b  

^a ASTRAZENECA R AND D   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; CYTOCHROME P450; CYTOCHROME P450 2C8; N DESETHYLAMODIAQUINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CORRELATION ANALYSIS; DRUG CLEARANCE; DRUG DISPOSITION; DRUG METABOLISM; ENZYME ANALYSIS; ENZYME METABOLISM; ENZYME SPECIFICITY; HUMAN; HUMAN TISSUE; HYDROXYLATION; LIVER MICROSOME; PRIORITY JOURNAL;

AMODIAQUINE; ANTIMALARIALS; ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DEALKYLATION; HUMANS; ISOENZYMES; LIVER; MASS SPECTROMETRY; MICROSOMES, LIVER; MODELS, MOLECULAR; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY, ULTRAVIOLET; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY;

EID: 0036154008     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.300.2.399     Document Type: Article

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