New designer drug 4′-methyl-α-pyrrolidinohexanophenone: Studies on its metabolism and toxicological detection in urine using gas chromatography-mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 789, Issue 1, 2003, Pages 79-91

  Springer, Dietmar ^a   Peters, Frank T ^a   Fritschi, Giselher ^b   Maurer, Hans H ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b Hessisches Landeskriminalamt   (Germany)

Author keywords

4 Methyl pyrrolidinohexanophenone; Designer drug; Metabolism

Indexed keywords

ACETYLATION; DRUG PRODUCTS; EXTRACTION; HYDROXYLATION; MASS SPECTROMETRY;

DRUG MARKETS;

GAS CHROMATOGRAPHY;

4' METHYL ALPHA PYRROLIDINOHEXANOPHENONE; CARBOXYLIC ACID; DESIGNER DRUG; DRUG METABOLITE; LACTAM; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ACETYLATION; CHEMICAL REACTION; CONFERENCE PAPER; ETHYLATION; GAS CHROMATOGRAPHY; HYDROGENATION; HYDROXYLATION; MASS SPECTROMETRY; PRIORITY JOURNAL; SCREENING; SOLID PHASE EXTRACTION; URINALYSIS; URINE;

EID: 0037420911     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(03)00043-6     Document Type: Conference Paper

References (33)

1. Roesner P., Junge T., Fritschi G., Klein B., Thielert K., Kozlowski M. Toxichem. Krimtech. 66:1999;81.
2. Springer D., Peters F.T., Fritschi G., Maurer H.H. Pragst F., Aderjan R. Proceedings of the XIIth GTFCh Symposium in Mosbach. 2001;156 Helm, Heppenheim, Germany.
3. Springer D., Peters F.T., Fritschi G., Maurer H.H. Balikova M., Navakova E. Proceedings of the 39th International TIAFT Meeting in Prague, 2001, Charles University, Prague. 2002. 122.
4. Springer D., Peters F.T., Fritschi G., Maurer H.H. J. Chromatogr. B. 773:2002;25.
5. Martinez M., Mercado O., Santamaria A., Galvan S., Vazquez M., Bucio V., Hall C., Hernandez R., Hurtazo A., Pego E., Rodriguez F., Salvatierra R., Sosa A., Rios C. Proc. West. Pharmacol. Soc. 41:1998;125.
6. Glennon R.A., Yousif M., Naiman N., Kalix P. Pharmacol. Biochem. Behav. 26:1987;547.
7. Kalix P., Glennon R.A. Biochem. Pharmacol. 35:1986;3015.
8. Bryant S.G., Guernsey B.G., Ingrim N.B. Clin. Pharm. 2:1983;525.
9. Maurer H.H. Pfleger K., Maurer H.H., Weber A. Mass Spectral and GC Data of Drugs, Poisons, Pesticides, Pollutants and Their Metabolites. 2nd ed:2000;3 Wiley-VCH, Weinheim. Part 4.
10. McKay A.F., Ott W.L., Taylor G.W., Buchanan M.N., Crooker J.F. Can. J. Res. (Sec. B). 28:1950;683.
11. Kraemer T., Weber A.A., Maurer H.H. Pragst F. Proceedings of the 10th GTFCh Symposium in Mosbach. 1997;200 Helm, Heppenheim. ISBN 3-923032-10-2.
12. Maurer H.H., Bickeboeller-Friedrich J., Kraemer T., Peters F.T. Toxicol. Lett. 112:2000;133.
13. Maurer H.H. Spectroscopy Europe. 6:1994;21.
14. K. Pfleger, H.H. Maurer, A. Weber, Mass Spectral Library of Drugs, Poisons, Pesticides, Pollutants and their Metabolites, 4th Rev., Agilent Technologies, Palo Alto, CA, 2003 (in preparation).
15. Staack R.F., Fritschi G., Maurer H.H. J. Chromatogr. B. 773:2002;35.
16. Bickeboeller-Friedrich J., Maurer H.H. Ther. Drug Monit. 23:2001;61.
17. Maurer H.H. Comb. Chem. High Throughput Screen. 3:2000;461.
18. Maurer H.H., Bickeboeller-Friedrich J. J. Anal. Toxicol. 24:2000;340.
19. Pokrajac M., Miljkovic B., Misailovic B. Rapid. Commun. Mass Spectrom. 5:1991;59.
20. Brenneisen R., Geisshusler S. Pharm. Acta Helv. 60:1985;290.
21. Kraemer T., Bickeboeller-Friedrich J., Maurer H.H. Drug Metab. Dispos. 28:2000;339.
22. Pfleger K., Maurer H.H., Weber A. Mass Spectral and GC Data of Drugs, Poisons, Pesticides, Pollutants and Their Metabolites. 2nd ed:2000;Wiley-VCH, Weinheim. Part 4.
23. McLafferty F.W., Turecek F. Interpretation of Mass Spectra. 1993;University Science Books, Mill Valley, CA.
24. Pfleger K., Maurer H.H., Weber A. Mass Spectral and GC Data of Drugs, Poisons, Pesticides, Pollutants and Their Metabolites. 2nd ed:1992;VCH, Weinheim.
25. Maurer H.H., Bickeboeller-Friedrich J. Ther. Drug Monit. 19:1997;583.
26. Kraemer T., Maurer H.H. Ther. Drug Monit. 24:2002;277.
27. Beckett A.H., Stanojcic M. J. Pharm. Pharmacol. 39:1987;409.
28. Markantonis S.L., Kyroudis A., Beckett A.H. Biochem. Pharmacol. 35:1986;529.
29. Schwetlick K. Organikum. 2001;Wiley-VCH, Weinheim.
30. K. Pfleger, H.H. Maurer, A. Weber, Mass Spectral and GC Data of Drugs, Poisons, Pesticides, Pollutants and their Metabolites, 2nd ed., Part 5, Wiley-VCH, Weinheim, 2003 (in preparation).
31. Kovats E. Helv. Chim. Acta. 41:1958;1915.
32. de-Zeeuw R.A., Franke J.P., Maurer H.H., Pfleger K. Gas Chromatographic Retention Indices of Toxicologically Relevant Substances and Their Metabolites. 1992;VCH, Weinheim. report of the DFG Commission for Clinical Toxicological Analysis, special issue of the TIAFT Bulletin.
33. DFG Senatskommission für Klinisch-toxikologische Analytik. J. Clin. Chem. Clin. Biochem. 20:1982;699.