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Volumn 447, Issue 1, 2006, Pages 53-58

Topological role of cytochrome P450 2D6 active site residues

(5) Van Waterschoot, Robert A B a Keizers, Peter H J a De Graaf, Chris a Vermeulen, Nico P E a Tschirret Guth, Richard A b

a VU UNIVERSITY AMSTERDAM (Netherlands)

b MERCK RESEARCH LABORATORIES (United States)

Author keywords

Active site topology; Aryldiazenes; Cytochrome P450 2D6; Molecular modeling; Mutagenesis

Indexed keywords

AMINO ACID; ASPARTIC ACID; CYTOCHROME P450; CYTOCHROME P450 2D6; GLUTAMIC ACID; ISOLEUCINE; NITROGEN; OXYGEN; PHENYLALANINE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRROLE; THREONINE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; ELECTRICITY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SUBSTRATE COMPLEX; ISOMER; KINETICS; MODEL; MOLECULAR MODEL; MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; COMPUTER SIMULATION; CYTOCHROME P-450 CYP2D6; ENZYME ACTIVATION; ESCHERICHIA COLI; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 33644631544 PISSN: 00039861 EISSN: None Source Type: Journal
DOI: 10.1016/j.abb.2006.01.002 Document Type: Article

Times cited : (11)

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