Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6

Biochemical Journal

Volumn 345, Issue 3, 2000, Pages 565-571

  Ellis, S Wynne ^a   Hayhurst, Graham P ^a   Lightfoot, Tracy ^a   Smith, Gillian ^b   Harlow, Jacky ^a   Rowland Yeo, Karen ^a   Larsson, Cecilia ^a   Mahling, Jurgen ^a   Lim, Chang K ^c   Wolf, C Roland ^b   Blackburn, Michael G ^a   Lennard, Martin S ^a   Tucker, Geoffrey T ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Enantioselectivity; Hydrogen bonding; Metoprolol; Quinidine; Quinine

Indexed keywords

ALANINE; COMPLEMENTARY DNA; CYTOCHROME P450; DEBRISOQUINE; HYDROXYL GROUP; LIGAND; METHYL GROUP; METOPROLOL; QUINIDINE; QUININE; SERINE;

AMINO ACID SUBSTITUTION; ARTICLE; ENANTIOMER; ENZYME ACTIVE SITE; ENZYME KINETICS; HYDROGEN BOND; HYDROXYLATION; LIGAND BINDING; MICROSOME; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY; YEAST CELL;

ALANINE; AMINO ACID SUBSTITUTION; ASPARTIC ACID; BINDING SITES; CATALYTIC DOMAIN; CYTOCHROME P-450 CYP2D6; DEBRISOQUIN; ENZYME INHIBITORS; KINETICS; LIGANDS; METOPROLOL; MUTAGENESIS, SITE-DIRECTED; OXIDATION-REDUCTION; PROPRANOLOL; QUINIDINE; QUININE; SERINE; SUBSTRATE SPECIFICITY; YEASTS;

EID: 0034142293     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3450565     Document Type: Article

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