Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: Insight into P450 conformational plasticity and membrane interaction

Journal of Biological Chemistry

Volumn 281, Issue 9, 2006, Pages 5973-5981

  Zhao, Yonghong ^a   White, Mark A ^a   Muralidhara, B K ^a   Sun, Ling ^a   Halpert, James R ^a   Stout, C David ^b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; COMPLEXATION; CRYSTAL STRUCTURE; ENZYME INHIBITION; MOLECULAR STRUCTURE; PLASTICITY; REACTION KINETICS; SUBSTRATES;

ANTIFUNGAL AGENT; CONFORMATIONAL PLASTICITY; MEMBRANE INTERACTION; MICROSOMAL CYTOCHROME;

CYTOLOGY;

BIFONAZOLE; CYTOCHROME P450; TRYPTOPHAN; ANTIFUNGAL AGENT; CYTOCHROME P 450 CYP2B4 (RABBIT); CYTOCHROME P-450 CYP2B4 (RABBIT); IMIDAZOLE DERIVATIVE; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG ANALYSIS; DRUG INHIBITION; DRUG MECHANISM; ISOTHERMAL TITRATION CALORIMETRY; LIPOPHILICITY; NONHUMAN; PRIORITY JOURNAL; BINDING SITE; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; METABOLISM; MICROSOME; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

MAMMALIA;

ANTIFUNGAL AGENTS; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CELL MEMBRANE; CRYSTALLOGRAPHY, X-RAY; IMIDAZOLES; MICROSOMES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 33646854265     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M511464200     Document Type: Article

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