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Volumn 24, Issue 6, 2001, Pages 678-682
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Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities
a
a
TSUMURA AND CO
(Japan)
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Author keywords
Cephaeline; Emetine; Human; Ipecac syrup; Metabolism; P450
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Indexed keywords
1 METHYLXANTHINE;
1,7 DIMETHYLURIC ACID;
4' HYDROXYMEPHENYTOIN;
ALKALOID DERIVATIVE;
BUFURALOL;
CEPHAELINE;
CYTOCHROME P450;
CYTOCHROME P450 2D6;
CYTOCHROME P450 3A4;
DRUG METABOLITE;
EMETINE;
HYDROXYTOLBUTAMIDE;
IPECAC;
MEPHENYTOIN;
PHENOBARBITAL;
PROADIFEN;
PROPRANOLOL;
QUINIDINE;
SULFAPHENAZOLE;
TESTOSTERONE;
THEOPHYLLINE;
TOLBUTAMIDE;
TRANYLCYPROMINE;
ARTICLE;
COMPARATIVE STUDY;
CONTROLLED STUDY;
DEMETHYLATION;
DRUG BLOOD LEVEL;
DRUG EFFECT;
DRUG METABOLISM;
DRUG STRUCTURE;
ENZYME ACTIVITY;
ENZYME INHIBITION;
ENZYME SUBSTRATE;
FEMALE;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
HUMAN;
HUMAN TISSUE;
IC 50;
IN VITRO STUDY;
INCUBATION TIME;
LIVER MICROSOME;
LIVER MICROSOME METABOLISM;
MALE;
METABOLITE;
PHARMACOKINETICS;
SAMPLE;
STATISTICAL ANALYSIS;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
CYTOCHROME P-450 ENZYME SYSTEM;
EMETICS;
EMETINE;
HUMANS;
METHYLATION;
MICROSOMES, LIVER;
RECOMBINANT PROTEINS;
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EID: 0034960661
PISSN: 09186158
EISSN: None
Source Type: Journal
DOI: 10.1248/bpb.24.678 Document Type: Article |
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Times cited : (24)
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References (21)
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