-
1
-
-
0027489755
-
Correlation between site specificity and electrophilic frontier values in the metabolic hydroxylation of aromatic substrates: A molecular modelling study
-
ACKLAND, M. J., 1993, Correlation between site specificity and electrophilic frontier values in the metabolic hydroxylation of aromatic substrates: a molecular modelling study. Xenobiotica, 23, 1135-1144.
-
(1993)
Xenobiotica
, vol.23
, pp. 1135-1144
-
-
Ackland, M.J.1
-
2
-
-
0028787561
-
Selective induction of hepatic CYP1A2 by the oral administration of caffeine to rats
-
AYALOGU, E. O., SNELLING, J., LEWIS, D. F. V., TALWAR, S., CLIFFORD, M. N. and IOANNIDES, C., 1995, Selective induction of hepatic CYP1A2 by the oral administration of caffeine to rats. Biochimica et Biophysica Acta, 1272, 89-94.
-
(1995)
Biochimica et Biophysica Acta
, vol.1272
, pp. 89-94
-
-
Ayalogu, E.O.1
Snelling, J.2
Lewis, D.F.V.3
Talwar, S.4
Clifford, M.N.5
Ioannides, C.6
-
3
-
-
0025606337
-
Species variation in the response of the cytochrome P-450-dependent monoxygenase system to inducers and inhibitors
-
BOOBIS, A. R., SESARDIC, D., MURRAY, B. P., EDWARDS, R. J., SINGLETON, A. M., RICH, K. J., MURRAY, S., DE LA TORRE, R., SEGURA, J., PELKONEN, O., PASANEN, M., KOBAYASHI, S., ZHI-GUANG, T. and DAVIES, D. S., 1990, Species variation in the response of the cytochrome P-450-dependent monoxygenase system to inducers and inhibitors. Xenobiotica, 20, 1139-1161.
-
(1990)
Xenobiotica
, vol.20
, pp. 1139-1161
-
-
Boobis, A.R.1
Sesardic, D.2
Murray, B.P.3
Edwards, R.J.4
Singleton, A.M.5
Rich, K.J.6
Murray, S.7
De La Torre, R.8
Segura, J.9
Pelkonen, O.10
Pasanen, M.11
Kobayashi, S.12
Zhi-Guang, T.13
Davies, D.S.14
-
4
-
-
0028853940
-
Species variation in the metabolism of 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one to its 3,4-dihydrodiol, the proximate carcinogen
-
BOYD, G. W., COOMBS, M. M., IONNIDES, C., LEWIS, D. F. V., SNELLING and TSAKALOF, A., 1995, Species variation in the metabolism of 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one to its 3,4-dihydrodiol, the proximate carcinogen. Carcinogenesis, 16, 2351-2355.
-
(1995)
Carcinogenesis
, vol.16
, pp. 2351-2355
-
-
Boyd, G.W.1
Coombs, M.M.2
Ionnides, C.3
Lewis, D.F.V.4
Snelling5
Tsakalof, A.6
-
5
-
-
8244231986
-
Species differences in the in vitro metabolism of probe substrates for the CYP2 enzymes
-
edited by M. C. Lechner (Paris: Libbey)
-
COHCORAN, O. M., HYLAND, R., JONES, B. C. and SMITH, D. A., 1994, Species differences in the in vitro metabolism of probe substrates for the CYP2 enzymes. In Cytochrome P450 : Proceedings of the 8th International Conference, edited by M. C. Lechner (Paris: Libbey), pp. 761-764.
-
(1994)
Cytochrome P450 : Proceedings of the 8th International Conference
, pp. 761-764
-
-
Cohcoran, O.M.1
Hyland, R.2
Jones, B.C.3
Smith, D.A.4
-
6
-
-
0025848338
-
A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6
-
CRESPI, C. L., PENMAN, B. W., GELBOIN, H. V. and GONZALEZ, F. J., 1991, A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6. Carcinogenesis, 12, 1197-1201.
-
(1991)
Carcinogenesis
, vol.12
, pp. 1197-1201
-
-
Crespi, C.L.1
Penman, B.W.2
Gelboin, H.V.3
Gonzalez, F.J.4
-
7
-
-
34547383064
-
Comparison of substrate metabolism by wild type CYP2D6 protein and a variant containing methionine, not valine, at position 374
-
Seattle, Washington, 27-31 August, 1995
-
CRESPI, C. L., STEIMEL, D. T., PENMAN, B. W., KORZEKWA, K. R., FERNANDEZ-SALGUERO, P., BUTERS, J. T. M., GELBOIN, H. V., GONZALEZ, F. J., IDLE, J. R. and DALY, A. K., 1995, Comparison of substrate metabolism by wild type CYP2D6 protein and a variant containing methionine, not valine, at position 374. In Proceedings of the 4th International ISSX Meeting, Seattle, Washington, 27-31 August, 1995, p. 54.
-
(1995)
Proceedings of the 4th International ISSX Meeting
, pp. 54
-
-
Crespi, C.L.1
Steimel, D.T.2
Penman, B.W.3
Korzekwa, K.R.4
Fernandez-Salguero, P.5
Buters, J.T.M.6
Gelboin, H.V.7
Gonzalez, F.J.8
Idle, J.R.9
Daly, A.K.10
-
8
-
-
0029073965
-
Antipeptide antibodies against overlapping sequences differentially inhibit human CYP2D6
-
CRIBB, A., NUSS, C. and WANG, R., 1995, Antipeptide antibodies against overlapping sequences differentially inhibit human CYP2D6. Drug Metabolism and Disposition, 23, 671-675.
-
(1995)
Drug Metabolism and Disposition
, vol.23
, pp. 671-675
-
-
Cribb, A.1
Nuss, C.2
Wang, R.3
-
9
-
-
0024557660
-
Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P450db, activity
-
DAYER, P., LEEMAN, T. and STRIBERNI, R., 1989, Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P450db, activity. Clinical Pharmacology and Therapeutics, 45, 34-40.
-
(1989)
Clinical Pharmacology and Therapeutics
, vol.45
, pp. 34-40
-
-
Dayer, P.1
Leeman, T.2
Striberni, R.3
-
10
-
-
0029008593
-
Computer prediction and experimental validation of cytochrome P4502D6-dependent oxidation of GBR 12909
-
DE GROOT, M. J., BULOO, G. J., HANSEN, K. T. and VERMEULEN, N. P. E., 1995, Computer prediction and experimental validation of cytochrome P4502D6-dependent oxidation of GBR 12909, Drug Metabolism and Disposition, 23, 667-669.
-
(1995)
Drug Metabolism and Disposition
, vol.23
, pp. 667-669
-
-
De Groot, M.J.1
Buloo, G.J.2
Hansen, K.T.3
Vermeulen, N.P.E.4
-
11
-
-
0027443640
-
Molecular evolution of P450 superfamily and P450-containing monooxygenase systems
-
DEGTYARENKO, K. N. and ARCHAKOV, A. I., 1993, Molecular evolution of P450 superfamily and P450-containing monooxygenase systems. FEBS Letters, 332, 1-8.
-
(1993)
FEBS Letters
, vol.332
, pp. 1-8
-
-
Degtyarenko, K.N.1
Archakov, A.I.2
-
12
-
-
0028840740
-
Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans
-
DIXON, C. M., COLTHUP, P. V., SERABJIT-SINGH, C. J., KERR, B. M., BOEHLERT, C. C., PARK, G. R. and TARBIT, M. H., 1995, Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans. Drug Metabolism and Disposition, 23, 1225-1230.
-
(1995)
Drug Metabolism and Disposition
, vol.23
, pp. 1225-1230
-
-
Dixon, C.M.1
Colthup, P.V.2
Serabjit-Singh, C.J.3
Kerr, B.M.4
Boehlert, C.C.5
Park, G.R.6
Tarbit, M.H.7
-
13
-
-
0025305464
-
The genetic polymorphism of debrisoquine/sparteine metabolism in clinical aspects
-
EICHELBAUM, M. and GROSS, A. S., 1990, The genetic polymorphism of debrisoquine/sparteine metabolism in clinical aspects. Pharmacology and Therapeutics, 46, 377-394.
-
(1990)
Pharmacology and Therapeutics
, vol.46
, pp. 377-394
-
-
Eichelbaum, M.1
Gross, A.S.2
-
14
-
-
0022517927
-
The genetic polymorphism of sparteine metabolism
-
EICHELBAUM, M., REETZ, K.-P., SCHMIDT, E. K. and ZEKORN, C., 1986, The genetic polymorphism of sparteine metabolism. Xenobiotica, 16, 465-481.
-
(1986)
Xenobiotica
, vol.16
, pp. 465-481
-
-
Eichelbaum, M.1
Reetz, K.-P.2
Schmidt, E.K.3
Zekorn, C.4
-
15
-
-
0026630501
-
Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast
-
ELLIS, S. W., CHING, M. S., WATSON, P. F., HENDERSON, C. J., SIMULA, A. P., LENNARD, M. S., TUCKER, G. T. and WOODS, H. F., 1992, Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast. Biochemical Pharmacology, 44, 617-620.
-
(1992)
Biochemical Pharmacology
, vol.44
, pp. 617-620
-
-
Ellis, S.W.1
Ching, M.S.2
Watson, P.F.3
Henderson, C.J.4
Simula, A.P.5
Lennard, M.S.6
Tucker, G.T.7
Woods, H.F.8
-
16
-
-
8244237786
-
A role for Asp-301 in cytochrome P4502D6 catalysis
-
Toronto, Canada
-
ELLIS, W., SIMULA, A., HARLOW, J., HAYHURST, G., SMITH, G., LENNARD, M., TUCKER, G. and WOLF, C. R., 1994, A role for Asp-301 in cytochrome P4502D6 catalysis. In 10th International Symposium on Microsomes and Drug Oxidations, Toronto, Canada, p. 427.
-
(1994)
10th International Symposium on Microsomes and Drug Oxidations
, pp. 427
-
-
Ellis, W.1
Simula, A.2
Harlow, J.3
Hayhurst, G.4
Smith, G.5
Lennard, M.6
Tucker, G.7
Wolf, C.R.8
-
17
-
-
0029999399
-
Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol
-
ELLIS, S. W., ROWLAND, K., ACKLAND, M. J., REKKA, E., SIMULA, A. P., LENNARD, M. S., WOLF, C. R. and TUCKER, G. T., 1996, Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol. Biochemical Journal, 316, 647-654.
-
(1996)
Biochemical Journal
, vol.316
, pp. 647-654
-
-
Ellis, S.W.1
Rowland, K.2
Ackland, M.J.3
Rekka, E.4
Simula, A.P.5
Lennard, M.S.6
Wolf, C.R.7
Tucker, G.T.8
-
18
-
-
0028223289
-
The polymorphic cytochrome P-450 2D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron
-
FISCHER, V., VICKERS, A. E. M., HEITZ, F., MAHADEVAN, S., BALDECK, J.-P., MINERY, P. and TYNES, R., 1994, The polymorphic cytochrome P-450 2D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron. Drug Metabolism and Disposition, 22, 269-274.
-
(1994)
Drug Metabolism and Disposition
, vol.22
, pp. 269-274
-
-
Fischer, V.1
Vickers, A.E.M.2
Heitz, F.3
Mahadevan, S.4
Baldeck, J.-P.5
Minery, P.6
Tynes, R.7
-
19
-
-
0000818292
-
Cytochrome P450 in rodents
-
edited by J. B. Schenkman and H. Griem (Berlin: Springer)
-
FUNAE, Y. and IMAOKA, S., 1993, Cytochrome P450 in rodents. In Cytochrome P450, edited by J. B. Schenkman and H. Griem (Berlin: Springer), pp. 221-238.
-
(1993)
Cytochrome P450
, pp. 221-238
-
-
Funae, Y.1
Imaoka, S.2
-
20
-
-
0028272001
-
Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins
-
GONZALEZ, F. J. and GELBOIN, H. V., 1994, Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins. Drug Metabolism Reviews, 26, 165-183.
-
(1994)
Drug Metabolism Reviews
, vol.26
, pp. 165-183
-
-
Gonzalez, F.J.1
Gelboin, H.V.2
-
21
-
-
0023854270
-
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism
-
GONZALEZ, F. J., SKODA, R. C., KIMURA, S., UMENO, M., ZANGER, U. M., NEBERT, D. W., GELBOIN, H. V., HARDWICK, J. P. and MEYER, U. A., 1988a, Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature, 331, 442-446.
-
(1988)
Nature
, vol.331
, pp. 442-446
-
-
Gonzalez, F.J.1
Skoda, R.C.2
Kimura, S.3
Umeno, M.4
Zanger, U.M.5
Nebert, D.W.6
Gelboin, H.V.7
Hardwick, J.P.8
Meyer, U.A.9
-
22
-
-
0023954396
-
Human debrisoquine 4-hydroxylase (P450IIDI): CDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22
-
GONZALEZ, F. J., VILBOIS, F., HARDWICK, J. P., MCBRIDE, O. W., NEBERT, D. W., GELBOIN, H. V. and MEYER, U. A., 1988b, Human debrisoquine 4-hydroxylase (P450IIDI): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22. Genomics, 2, 174-179.
-
(1988)
Genomics
, vol.2
, pp. 174-179
-
-
Gonzalez, F.J.1
Vilbois, F.2
Hardwick, J.P.3
Mcbride, O.W.4
Nebert, D.W.5
Gelboin, H.V.6
Meyer, U.A.7
-
23
-
-
0026542989
-
Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences
-
GOTOH, O., 1992, Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences. Journal of Biological Chemistry, 267, 83-90.
-
(1992)
Journal of Biological Chemistry
, vol.267
, pp. 83-90
-
-
Gotoh, O.1
-
24
-
-
0028316987
-
Atypical metabolism of deprenyl and its enantiomer, (S)-(+)-N,α-dimethyl-propynylphenethylamine, by cytochrome P450 2D6
-
GRACE, J. M., KINTER, M. T. and MACDONALD, T. L., 1994, Atypical metabolism of deprenyl and its enantiomer, (S)-(+)-N,α-dimethyl-propynylphenethylamine, by cytochrome P450 2D6. Chemical Research in Toxicology, 7, 286-290.
-
(1994)
Chemical Research in Toxicology
, vol.7
, pp. 286-290
-
-
Grace, J.M.1
Kinter, M.T.2
Macdonald, T.L.3
-
25
-
-
0029892263
-
P450s: Structural similarities and functional differences
-
GRAHAM-LORENCE, S. and PETERSON, J. A., 1996, P450s: structural similarities and functional differences, FASEB Journal, 10, 206-214.
-
(1996)
FASEB Journal
, vol.10
, pp. 206-214
-
-
Graham-Lorence, S.1
Peterson, J.A.2
-
26
-
-
8244254433
-
Characterization of mutants in the P450 domain of P450BM3
-
Toronto, Canada, 18-21 July, 1994
-
GRAHAM-LORENCE, S., SANDERS, D. and PETERSON, J. A., 1994, Characterization of mutants in the P450 domain of P450BM3. In Proceedings of the 10th International Symposium on Microsomes and Drug Oxidations, Toronto, Canada, 18-21 July, 1994, p. 435.
-
(1994)
Proceedings of the 10th International Symposium on Microsomes and Drug Oxidations
, pp. 435
-
-
Graham-Lorence, S.1
Sanders, D.2
Peterson, J.A.3
-
27
-
-
0029643786
-
Structure and function of cytochromes P450: A comparative analysis of three crystal structures
-
HASEMANN, C. A., KURUMBAIL, R. G., BODDUPALLI, S. S., PETERSON, J. A. and DEISENHOFER, J., 1995, Structure and function of cytochromes P450: a comparative analysis of three crystal structures. Structure, 3, 41-62.
-
(1995)
Structure
, vol.3
, pp. 41-62
-
-
Hasemann, C.A.1
Kurumbail, R.G.2
Boddupalli, S.S.3
Peterson, J.A.4
Deisenhofer, J.5
-
28
-
-
0025080352
-
Genotyping of poor metabolizers of debrisoquine by allele-specific PCR amplification
-
HEIM, M. and MEYER, V. A., 1990, Genotyping of poor metabolizers of debrisoquine by allele-specific PCR amplification. Lancet, 336, 529-532.
-
(1990)
Lancet
, vol.336
, pp. 529-532
-
-
Heim, M.1
Meyer, V.A.2
-
29
-
-
0026046988
-
A three-dimensional molecular template for substrates of human cytochrome P450 involved in debrisoquine 4-hydroxylation
-
ISLAM, S. A., WOLF, C. R., LENNARD, M. S. and STERNBERG, M. J. E., 1991, A three-dimensional molecular template for substrates of human cytochrome P450 involved in debrisoquine 4-hydroxylation. Carcinogenesis, 12, 2211-2219.
-
(1991)
Carcinogenesis
, vol.12
, pp. 2211-2219
-
-
Islam, S.A.1
Wolf, C.R.2
Lennard, M.S.3
Sternberg, M.J.E.4
-
30
-
-
0027411643
-
Predicting the cytochrome P450 mediated metabolism of xenobiotics
-
KORZEKWA, K. R. and JONES, J. P., 1993, Predicting the cytochrome P450 mediated metabolism of xenobiotics. Pharmacogenetics, 3, 1-18.
-
(1993)
Pharmacogenetics
, vol.3
, pp. 1-18
-
-
Korzekwa, K.R.1
Jones, J.P.2
-
31
-
-
0026553661
-
A predictive model for substrates of cytochrome P-450-debrisoquine (2D6)
-
KOYMANS, L., VERMEULEN, N. P. E., VAN ACKER, S. A. B. E., TE KOPPELE, J. M., HEYKANTS, J. J. P., LAVRIJSEN, K., MEULDERMANS, W. and DONNÉ-OP DEN KELDER, G. M., 1992, A predictive model for substrates of cytochrome P-450-debrisoquine (2D6). Chemical Research in Toxicology, 5, 211-219.
-
(1992)
Chemical Research in Toxicology
, vol.5
, pp. 211-219
-
-
Koymans, L.1
Vermeulen, N.P.E.2
Van Acker, S.A.B.E.3
Te Koppele, J.M.4
Heykants, J.J.P.5
Lavrijsen, K.6
Meuldermans, W.7
Donné-Op Den Kelder, G.M.8
-
32
-
-
0027613291
-
A preliminary 3D model for cytochrome P450 2D6 constructed by homology model building
-
KOYMANS, L. M. H., VERMEULEN, N. P. E., BAARSLAG, A. and DONNE-OP DEN KELDER, G. M., 1993, A preliminary 3D model for cytochrome P450 2D6 constructed by homology model building. Journal of Computer-Aided Molecular Design, 7, 281-289.
-
(1993)
Journal of Computer-Aided Molecular Design
, vol.7
, pp. 281-289
-
-
Koymans, L.M.H.1
Vermeulen, N.P.E.2
Baarslag, A.3
Donne-Op Den Kelder, G.M.4
-
34
-
-
0022470627
-
Debrisoquine polymorphism and the metabolism and action of metoprolol, timolol, propranolol and atenolol
-
LENNARD, M. S., TUCKER, G. T., SILAS, J. H. and WOODS, H. F., 1986, Debrisoquine polymorphism and the metabolism and action of metoprolol, timolol, propranolol and atenolol. Xenobiotica, 16, 435-447.
-
(1986)
Xenobiotica
, vol.16
, pp. 435-447
-
-
Lennard, M.S.1
Tucker, G.T.2
Silas, J.H.3
Woods, H.F.4
-
36
-
-
3042930847
-
The cytochromes P450: Ubiquitous enzymes of metabolism
-
LEWIS, D. F. V. 1995b, The cytochromes P450: ubiquitous enzymes of metabolism. Manufacturing Chemist, 66, 35-37.
-
(1995)
Manufacturing Chemist
, vol.66
, pp. 35-37
-
-
Lewis, D.F.V.1
-
38
-
-
0002368374
-
Molecular modelling of mammalian cytochromes P450 with specific substrates and inhibitors
-
edited by C. Ioannides (Boca Raton: CRC Press)
-
LEWIS, D. F. V., 1996b, Molecular modelling of mammalian cytochromes P450 with specific substrates and inhibitors. In Cytochromes P450 : Metabolic and Toxicological Aspects, edited by C. Ioannides (Boca Raton: CRC Press), pp. 353-389.
-
(1996)
Cytochromes P450 : Metabolic and Toxicological Aspects
, pp. 353-389
-
-
Lewis, D.F.V.1
-
39
-
-
0029088125
-
Molecular modelling of members of the CYP2A subfamily: Application to studies of enzyme specificity
-
LEWIS, D. F. V. and LAKE, B. G., 1995, Molecular modelling of members of the CYP2A subfamily: application to studies of enzyme specificity. Xenobiotica, 25, 585-598.
-
(1995)
Xenobiotica
, vol.25
, pp. 585-598
-
-
Lewis, D.F.V.1
Lake, B.G.2
-
40
-
-
0030036211
-
Molecular modelling of CYP1A subfamily members based on an alignment with CYP102: Rationalization of CYPlA substrate specificity in terms of active site amino acid residues
-
LEWIS, D. F. V. and LAKE, B. G., 1996, Molecular modelling of CYP1A subfamily members based on an alignment with CYP102: rationalization of CYPlA substrate specificity in terms of active site amino acid residues. Xenobiotica, 26, 723-753.
-
(1996)
Xenobiotica
, vol.26
, pp. 723-753
-
-
Lewis, D.F.V.1
Lake, B.G.2
-
41
-
-
0029589468
-
Molecular orbital-generated QSARs in an homologous series of alkoxy resorufins and studies of their interactive docking with cytochromes P450
-
LEWIS, D. F. V., LAKE, B. G. and PARKE, D. V., 1995, Molecular orbital-generated QSARs in an homologous series of alkoxy resorufins and studies of their interactive docking with cytochromes P450. Xenobiotica, 25, 1355-1369.
-
(1995)
Xenobiotica
, vol.25
, pp. 1355-1369
-
-
Lewis, D.F.V.1
Lake, B.G.2
Parke, D.V.3
-
42
-
-
0029805701
-
Molecular modelling of CYP3A4 from an alignment with CYP102: Identification of key interactions between putative active site residues and CYP3A-specific chemicals
-
LEWIS, D. F. V., EDDERSHAW, P. J., GOLDFARB, P. S. and TARBIT, M. H., 1996, Molecular modelling of CYP3A4 from an alignment with CYP102: Identification of key interactions between putative active site residues and CYP3A-specific chemicals. Xenobiotica, 26, 1067-1086.
-
(1996)
Xenobiotica
, vol.26
, pp. 1067-1086
-
-
Lewis, D.F.V.1
Eddershaw, P.J.2
Goldfarb, P.S.3
Tarbit, M.H.4
-
43
-
-
0024976419
-
coh substrate specificity by mutation of a single amino-acid residue
-
coh substrate specificity by mutation of a single amino-acid residue. Nature 339, 632-634.
-
(1989)
Nature
, vol.339
, pp. 632-634
-
-
Lindberg, R.L.P.1
Negishi, M.2
-
44
-
-
0028826569
-
A novel CYP2D6 allele with an abolished splice recognition site associated with the poor metabolizer phenotype
-
MAREZ, D., SABBAGH, N., LEGRAND, M., LO, J. M., GUDDICHI, G. M., BOONE, P. and BROLY, F., 1995, A novel CYP2D6 allele with an abolished splice recognition site associated with the poor metabolizer phenotype. Pharmacogenetics, 5, 305-311.
-
(1995)
Pharmacogenetics
, vol.5
, pp. 305-311
-
-
Marez, D.1
Sabbagh, N.2
Legrand, M.3
Lo, J.M.4
Guddichi, G.M.5
Boone, P.6
Broly, F.7
-
45
-
-
0025103871
-
Sequence requirements for cytochrome P-450IID1 catalytic activity
-
MATSUNAGA, E., ZEUGIN, T., ZANGER, U. M., AOYAMA, T., MEYER, U. A. and GONZALEZ, F. J., 1990, Sequence requirements for cytochrome P-450IID1 catalytic activity. Journal of Biological Chemistry, 265, 17197-17201.
-
(1990)
Journal of Biological Chemistry
, vol.265
, pp. 17197-17201
-
-
Matsunaga, E.1
Zeugin, T.2
Zanger, U.M.3
Aoyama, T.4
Meyer, U.A.5
Gonzalez, F.J.6
-
46
-
-
8244226055
-
Molecular mechanisms causing genetic polymorphisms of drug metabolizing enzymes
-
MEYER, U. A., 1991, Molecular mechanisms causing genetic polymorphisms of drug metabolizing enzymes. Frontiers in Biotransformation, 9, 215-245.
-
(1991)
Frontiers in Biotransformation
, vol.9
, pp. 215-245
-
-
Meyer, U.A.1
-
47
-
-
0022899555
-
The molecular mechanisms of two common polymorphisms of drug oxidation-evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation
-
MEYER, V. A., GUT, J., KRONBACH, T., SKODA, C., MEIER, U. T., CATIN, T. and DAYER, P., 1986, The molecular mechanisms of two common polymorphisms of drug oxidation-evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation. Xenobiotica, 16, 449-464.
-
(1986)
Xenobiotica
, vol.16
, pp. 449-464
-
-
Meyer, V.A.1
Gut, J.2
Kronbach, T.3
Skoda, C.4
Meier, U.T.5
Catin, T.6
Dayer, P.7
-
48
-
-
24544468963
-
Clinical implications of genetic polymorphisms in human drug metabolism
-
MIKUS, G., KROEMER, N. K. and EICHELBAUM, M., 1994, Clinical implications of genetic polymorphisms in human drug metabolism. Frontiers in Biotransformation, 9, 215-245.
-
(1994)
Frontiers in Biotransformation
, vol.9
, pp. 215-245
-
-
Mikus, G.1
Kroemer, N.K.2
Eichelbaum, M.3
-
49
-
-
0029116115
-
NMR studies of substrate binding to cytochrome P450BM3: Comparisons to cytochrome P450cam
-
MODI, S., PRIMROSE, W. U., BOYLE, J., GIBSON, C. F., LIAN, L.-Y. and ROBERTS, G. C. K., 1995, NMR studies of substrate binding to cytochrome P450BM3: comparisons to cytochrome P450cam. Biochemistry, 34, 8982-8988.
-
(1995)
Biochemistry
, vol.34
, pp. 8982-8988
-
-
Modi, S.1
Primrose, W.U.2
Boyle, J.3
Gibson, C.F.4
Lian, L.-Y.5
Roberts, G.C.K.6
-
50
-
-
0029914807
-
4502D6 based on homology modeling and NMR studies of substrate binding
-
4502D6 based on homology modeling and NMR studies of substrate binding. Biochemistry, 35, 4540-4550.
-
(1996)
Biochemistry
, vol.35
, pp. 4540-4550
-
-
Modi, S.1
Paine, M.J.2
Sutcliffe, M.J.3
Lian, L.-Y.4
Primrose, W.U.5
Wolf, C.R.6
Roberts, G.C.K.7
-
51
-
-
9044254525
-
P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
-
NELSON, D. R., KOYMANS, L., KAMATAKI, T., STEGEMAN, J. J., FEYEREISEN, R., WAXMAN, D. J., WATERMAN, M. R., GOTOH, O., COON, M. J., ESTABROOK, R. W., GUNSALUS, I. C. and NEBERT, D. W., 1996, P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics, 6, 1-42.
-
(1996)
Pharmacogenetics
, vol.6
, pp. 1-42
-
-
Nelson, D.R.1
Koymans, L.2
Kamataki, T.3
Stegeman, J.J.4
Feyereisen, R.5
Waxman, D.J.6
Waterman, M.R.7
Gotoh, O.8
Coon, M.J.9
Estabrook, R.W.10
Gunsalus, I.C.11
Nebert, D.W.12
-
52
-
-
0023788246
-
Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes
-
OTTON, S. V., CREWE, H. K., LENNARD, M. S., TUCKER, G. T. and WOODS, H. F., 1988, Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes. Journal of Pharmacology and Experimental Therapeutics, 247, 242-247.
-
(1988)
Journal of Pharmacology and Experimental Therapeutics
, vol.247
, pp. 242-247
-
-
Otton, S.V.1
Crewe, H.K.2
Lennard, M.S.3
Tucker, G.T.4
Woods, H.F.5
-
54
-
-
0027512246
-
Characterization of a human cell line expressing high levels of cDNA-derived CYP2D6
-
PENMAN, B. W., REECE, J., SMITH, T., YANG, C. S., GELBOIN, H. V., GONZALEZ, F. J. and CRESPI, C. L., 1993, Characterization of a human cell line expressing high levels of cDNA-derived CYP2D6. Pharmacogenetics, 3, 28-39.
-
(1993)
Pharmacogenetics
, vol.3
, pp. 28-39
-
-
Penman, B.W.1
Reece, J.2
Smith, T.3
Yang, C.S.4
Gelboin, H.V.5
Gonzalez, F.J.6
Crespi, C.L.7
-
56
-
-
0027326717
-
Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450s
-
RAVICHANDRAN, K. G., BODDUPALLI, S., HASEMANN, C. A., PETERSON, J. A. and DIESENHOFER, J., 1993, Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450s. Science, 261, 731-736.
-
(1993)
Science
, vol.261
, pp. 731-736
-
-
Ravichandran, K.G.1
Boddupalli, S.2
Hasemann, C.A.3
Peterson, J.A.4
Diesenhofer, J.5
-
57
-
-
0003144721
-
Cancer genetics: Genetic factors in the activation and inactivation of chemical carcinogens
-
edited by C. Ioannides and D. F. V. Lewis (Chichester: Ellis Horwood)
-
RAUNIO, H. and PELKONEN, O., 1995, Cancer genetics: Genetic factors in the activation and inactivation of chemical carcinogens. In Drugs, Diet and Disease, vol. 1. Mechanistic Approaches to Cancer, edited by C. Ioannides and D. F. V. Lewis (Chichester: Ellis Horwood), pp. 229-258.
-
(1995)
Drugs, Diet and Disease, Vol. 1. Mechanistic Approaches to Cancer
, vol.1
, pp. 229-258
-
-
Raunio, H.1
Pelkonen, O.2
-
58
-
-
0028237729
-
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens, and toxic chemicals
-
SHIMADA, T., YAMAZAKI, H., MIMURA, M., INUI, Y. and GUENGERICH, F. P., 1994, Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens, and toxic chemicals. Journal of Pharmacology and Experimental Therapeutics, 270, 414-423.
-
(1994)
Journal of Pharmacology and Experimental Therapeutics
, vol.270
, pp. 414-423
-
-
Shimada, T.1
Yamazaki, H.2
Mimura, M.3
Inui, Y.4
Guengerich, F.P.5
-
59
-
-
0026459382
-
Speculations on the substrate structure-activity relationship (SSAR) of cytochrome P450 enzymes
-
SMITH, D. A. and JONES, B. C., 1992, Speculations on the substrate structure-activity relationship (SSAR) of cytochrome P450 enzymes. Biochemical Pharmacology, 44, 2089-2098.
-
(1992)
Biochemical Pharmacology
, vol.44
, pp. 2089-2098
-
-
Smith, D.A.1
Jones, B.C.2
-
60
-
-
7344239655
-
Cytochrome P450s: Selectivity and measurement in vivo
-
in press
-
SMITH, D. A., ABEL, S. M., HYLAND, R. and JONES, B. C., 1997, Cytochrome P450s: selectivity and measurement in vivo. Xenobiotica, (in press).
-
(1997)
Xenobiotica
-
-
Smith, D.A.1
Abel, S.M.2
Hyland, R.3
Jones, B.C.4
-
61
-
-
0027314831
-
Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: Molecular modelling and inhibition studies
-
STROBL, G. R., VON KRUEDENER, S., STOCKIGT, J., GUENGERICH, F. P. and WOLFF, T., 1993, Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: Molecular modelling and inhibition studies. Journal of Medicinal Chemistry, 36, 1136-1145.
-
(1993)
Journal of Medicinal Chemistry
, vol.36
, pp. 1136-1145
-
-
Strobl, G.R.1
Von Kruedener, S.2
Stockigt, J.3
Guengerich, F.P.4
Wolff, T.5
-
62
-
-
0028823597
-
Site-directed mutagenesis as a tool for molecular modelling of cytochrome P4502B1
-
SZKLARZ, G. D., HE, Y. A. and HALPERT, J. R., 1995, Site-directed mutagenesis as a tool for molecular modelling of cytochrome P4502B1, Biochemistry, 34, 14312-14322.
-
(1995)
Biochemistry
, vol.34
, pp. 14312-14322
-
-
Szklarz, G.D.1
He, Y.A.A.2
Halpert, J.R.3
-
63
-
-
0026240145
-
Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281 : Possible association with the poor metabolizer phenotype
-
TYNDALE, R., AOYAMA, T., BROLY, F., MATSUNAGA, T., INABA, T., KALOW, W., GELBOIN, H. V., MEYER, U. A. and GONZALEZ, F. J., 1991, Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281 : possible association with the poor metabolizer phenotype. Pharmacogenetics, 1, 26-32.
-
(1991)
Pharmacogenetics
, vol.1
, pp. 26-32
-
-
Tyndale, R.1
Aoyama, T.2
Broly, F.3
Matsunaga, T.4
Inaba, T.5
Kalow, W.6
Gelboin, H.V.7
Meyer, U.A.8
Gonzalez, F.J.9
-
64
-
-
0028902034
-
14C] tamoxifen to liver microsomes and the forms of cytochrome P450 involved
-
14C] tamoxifen to liver microsomes and the forms of cytochrome P450 involved. Biochemical Pharmacology, 49, 1035-1042.
-
(1995)
Biochemical Pharmacology
, vol.49
, pp. 1035-1042
-
-
White, I.N.H.1
De Matteis, F.2
Gibbs, A.H.3
Lim, C.K.4
Wolf, C.R.5
Henderson, C.6
Smith, L.L.7
-
65
-
-
0029935962
-
The metabolism of tamoxifen by human cytochromes P450 is rationalized by molecular modelling studies of the enzyme-substrate interactions
-
WISEMAN, H. and LEWIS, D. F. V., 1996, The metabolism of tamoxifen by human cytochromes P450 is rationalized by molecular modelling studies of the enzyme-substrate interactions. Carcinogenesis, 17, 1357-1360.
-
(1996)
Carcinogenesis
, vol.17
, pp. 1357-1360
-
-
Wiseman, H.1
Lewis, D.F.V.2
-
66
-
-
0021884394
-
Substrate specificity of human liver cytochrome P-450 debrisoquine 4-hydroxylase probed using immunochemical inhibition and chemical modelling
-
WOLFF, T., DISTLERATH, L. M., WORTHINGTON, M. T., GROOPMAN, J. D., HAMMONS, G. J., KADLUBAR, F. F., PROUGH, R. A., MARTIN, M. V. and GUENGERICH, F. P., 1985, Substrate specificity of human liver cytochrome P-450 debrisoquine 4-hydroxylase probed using immunochemical inhibition and chemical modelling. Cancer Research, 45, 2116-2122.
-
(1985)
Cancer Research
, vol.45
, pp. 2116-2122
-
-
Wolff, T.1
Distlerath, L.M.2
Worthington, M.T.3
Groopman, J.D.4
Hammons, G.J.5
Kadlubar, F.F.6
Prough, R.A.7
Martin, M.V.8
Guengerich, F.P.9
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