The effect of mutation of F87 on the properties of CYP102A1-CYP4C7 chimeras: Altered regiospecificity and substrate selectivity

Journal of Biological Inorganic Chemistry

Volumn 13, Issue 5, 2008, Pages 813-824

  Chen, Chiung Kuang J ^a   Shokhireva, Tatiana Kh ^a   Berry, Robert E ^a   Zhang, Hongjun ^a   Walker, F Ann ^a  

^a University of Arizona   (United States)

Author keywords

Cytochrome; Heme; Site directed mutagenesis

Indexed keywords

9 HYDROXYFARNESOL; ALANINE; AMINO ACID; CYTOCHROME P450; CYTOCHROME P450 BM3; FARNESOL; FATTY ACID DERIVATIVE; LAURIC ACID; LEUCINE; PALMITIC ACID; PHENYLALANINE; PROTEIN CYP4C7;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CHIMERA; ENZYME SPECIFICITY; OXIDATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

BACTERIAL PROTEINS; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; FARNESOL; LAURIC ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MUTANT CHIMERIC PROTEINS; NADP; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDATION-REDUCTION; PALMITIC ACID; POINT MUTATION; PROTEIN CONFORMATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPECTROPHOTOMETRY, ATOMIC; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS);

EID: 44549086314     PISSN: 09498257     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00775-008-0368-5     Document Type: Article

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