The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent

Biochemical Pharmacology

Volumn 70, Issue 8, 2005, Pages 1253-1261

  Lussenburg, Barbara M A ^a   Keizers, Peter H J ^a   De Graaf, Chris ^a   Hidestrand, Mats ^b   Ingelman Sundberg, M ^b   Vermeulen, Nico P E ^a   Commandeur, Jan N M ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Active site; Cytochrome P450 2D6; Phenylalanine 483; Site directed mutagenesis; Substrate selectivity

Indexed keywords

3 METHOXYMORPHINAN; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; 7 METHOXY 4 (AMINOMETHYL)COUMARIN; ALANINE; BUFURALOL; COUMARIN DERIVATIVE; CYTOCHROME P450 2D6; DEXTROMETHORPHAN; DEXTRORPHAN; MORPHINAN DERIVATIVE; PHENYLALANINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL PROCEDURES; CHEMICAL REACTION; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; LIGAND BINDING; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; WILD TYPE;

CYTOCHROME P-450 CYP2D6; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; PLASMIDS; SUBSTRATE SPECIFICITY;

EID: 24944497676     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.07.002     Document Type: Article

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