Metabolism of dextrorphan by CYP2D6 in different recombinantly expressed systems and its implications for the in vitro assessment of dextromethorphan metabolism

Journal of Pharmaceutical Sciences

Volumn 98, Issue 2, 2009, Pages 763-771

  Van, Linh M ^a,d   Sarda, Sunil ^b   Hargreaves, Judith A ^b   Rostami Hodjegan, Amin ^a,c  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c CERTARA UK LIMITED   (United Kingdom)

^d University of Southern California ^*  (United States)

Author keywords

Bactosomes ; CYP2D6 probes; Dextromethorphan; Dextrorphan; Supersomes

Indexed keywords

CYTOCHROME P450 2D6; DEXTROMETHORPHAN; DEXTRORPHAN; DRUG METABOLITE; NORLEVORPHANOL; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; DRUG DERIVATIVE; RECOMBINANT PROTEIN;

ARTICLE; DRUG METABOLISM; ENZYME ACTIVITY; HUMAN; HYDROXYLATION; METABOLIC RATE; MICROSOME; NONHUMAN; PROTEIN EXPRESSION; BACTERIUM; BIOTRANSFORMATION; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; KINETICS; MASS SPECTROMETRY; METABOLISM; MOLECULAR CLONING; SACCHAROMYCES CEREVISIAE;

BACTERIA; BIOTRANSFORMATION; CLONING, MOLECULAR; CYTOCHROME P-450 CYP2D6; DEXTROMETHORPHAN; DEXTRORPHAN; HUMANS; HYDROXYLATION; KINETICS; MASS SPECTROMETRY; MICROSOMES; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SUBSTRATE SPECIFICITY;

EID: 59849125083     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21455     Document Type: Article

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