Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 Å resolution: Evidence for multiple substrate binding modes

Biochemistry

Volumn 42, Issue 21, 2003, Pages 6370-6379

  Wester, Michael R ^a   Johnson, Eric F ^a   Marques Soares, Cristina ^b   Dansette, Patrick M ^b   Mansuy, Daniel ^b   Stout, C David ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER CONCENTRATION; COMPLEXATION; HYDROXYLATION; METABOLISM; SOLVENTS; SUBSTRATES; X RAY CRYSTALLOGRAPHY;

CYTOCHROMES;

PIGMENTS;

4 METHYL N METHYL N (2 PHENYL 2H PYRAZOL 3 YL)BENZENESULFONAMIDE; CYTOCHROME P450 2C; CYTOCHROME P450 2C5; CYTOCHROME P450 3LVDH; DRUG METABOLIZING ENZYME; HEME; IRON; METHYL GROUP; MICROSOME ENZYME; PROTEIN; SOLVENT; SULFONAMIDE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CHEMICAL BINDING; CHEMICAL REACTION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROXYLATION; MOLECULAR INTERACTION; MOLECULAR MODEL; MOLECULAR SIZE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; ELECTRONS; HEME; HUMANS; IMIDAZOLES; IRON; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; STEROID 21-HYDROXYLASE; WATER;

MAMMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0037672866     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0273922     Document Type: Article

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