Neurosteroid modulation of synaptic and extrasynaptic GABAA receptors

Pharmacology and Therapeutics

Volumn 116, Issue 1, 2007, Pages 20-34

  Herd, Murray B ^a   Belelli, Delia ^a   Lambert, Jeremy J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Extrasynaptic receptors; GABAA receptor; Inhibitory synaptic transmission; Neurosteroid; Tonic current

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3ALPHA HYDROXYSTEROID DEHYDROGENASE; 3ALPHA,21 DIHYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; FINASTERIDE; GANAXOLONE; L 655708; MIFEPRISTONE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; NEUROSTEROID; PREGNANE DERIVATIVE; PROTEIN KINASE C; RECEPTOR SUBUNIT; SKF 105111; STEROID 5ALPHA REDUCTASE; STEROID 5ALPHA REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANESTHESIA; ANTICONVULSANT ACTIVITY; AUTOCRINE EFFECT; BLOOD BRAIN BARRIER; BRAIN REGION; CENTRAL NERVOUS SYSTEM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG TARGETING; GABAERGIC SYSTEM; GENE EXPRESSION; HORMONE SYNTHESIS; HUMAN; HYPNOSIS; MAMMAL; NERVE CELL EXCITABILITY; NERVE CELL PLASTICITY; NEUROMODULATION; NONHUMAN; PARACRINE SIGNALING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SEDATION; SPINAL CORD; STEROID METABOLISM; TRANQUILIZING ACTIVITY;

ANIMALS; BINDING SITES; HUMANS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; PROTEIN BINDING; RECEPTORS, GABA-A; RECEPTORS, NEUROTRANSMITTER; STEROIDS; SYNAPTIC TRANSMISSION;

EID: 34548583303     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2007.03.007     Document Type: Review

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