메뉴 건너뛰기




Volumn 327, Issue 2, 2008, Pages 538-545

The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6

Author keywords

[No Author keywords available]

Indexed keywords

ANANDAMIDE; CANNABINOID 1 RECEPTOR; CYTOCHROME P450 2D6;

EID: 54349118188     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.141796     Document Type: Article
Times cited : (82)

References (32)
  • 1
    • 0033972055 scopus 로고    scopus 로고
    • Multiple forms of cytochrome P450 and associated monooxygenase activities in human brain mitochondria
    • Bhagwat SV, Boyd MR, and Ravindranath V (2000) Multiple forms of cytochrome P450 and associated monooxygenase activities in human brain mitochondria. Biochem Pharmacol 59:573-582.
    • (2000) Biochem Pharmacol , vol.59 , pp. 573-582
    • Bhagwat, S.V.1    Boyd, M.R.2    Ravindranath, V.3
  • 3
    • 0034805943 scopus 로고    scopus 로고
    • The CYP P450 arachidonic acid monooxygenases: From cell signaling to blood pressure regulation
    • Capdevila JH and Falck JR (2001) The CYP P450 arachidonic acid monooxygenases: from cell signaling to blood pressure regulation. Biochem Biophys Res Commun 285:571-576.
    • (2001) Biochem Biophys Res Commun , vol.285 , pp. 571-576
    • Capdevila, J.H.1    Falck, J.R.2
  • 4
    • 0034846861 scopus 로고    scopus 로고
    • A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus
    • Craib SJ, Ellington HC, Pertwee RG, and Ross RA (2001) A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus. Br J Pharmacol 134:30-37.
    • (2001) Br J Pharmacol , vol.134 , pp. 30-37
    • Craib, S.J.1    Ellington, H.C.2    Pertwee, R.G.3    Ross, R.A.4
  • 5
    • 0042572380 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase: An emerging therapeutic target in the endocannabinoid system
    • Cravatt BF and Lichtman AH (2003) Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system. Curr Opin Chem Biol 7:469-475.
    • (2003) Curr Opin Chem Biol , vol.7 , pp. 469-475
    • Cravatt, B.F.1    Lichtman, A.H.2
  • 6
    • 4544275181 scopus 로고    scopus 로고
    • The endocannabinoid system and its therapeutic exploitation
    • Di Marzo V, Bifulco M, and De Petrocellis L (2004) The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov 3:771-784.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 771-784
    • Di Marzo, V.1    Bifulco, M.2    De Petrocellis, L.3
  • 7
    • 37349090515 scopus 로고    scopus 로고
    • CYP2D6 polymorphism: Implications for antipsychotic drug response, schizophrenia and personality traits
    • Dorado P, Peñas-Lledó EM, and Llerena A (2007) CYP2D6 polymorphism: implications for antipsychotic drug response, schizophrenia and personality traits. Pharmacogenomics 8:1597-1608.
    • (2007) Pharmacogenomics , vol.8 , pp. 1597-1608
    • Dorado, P.1    Peñas-Lledó, E.M.2    Llerena, A.3
  • 8
    • 32944455130 scopus 로고    scopus 로고
    • Monoclonal antibodies and multifunctional cytochrome P450: Drug metabolism as paradigm
    • Gelboin HV and Krausz K (2006) Monoclonal antibodies and multifunctional cytochrome P450: drug metabolism as paradigm. J Clin Pharmacol 46:353-372.
    • (2006) J Clin Pharmacol , vol.46 , pp. 353-372
    • Gelboin, H.V.1    Krausz, K.2
  • 9
    • 4344568973 scopus 로고    scopus 로고
    • Potential role of cerebral cytochrome P450 in clinical pharmacokinetics: Modulation by endogenous compounds
    • Gervasini G, Carrillo JA, and Benitez J (2004) Potential role of cerebral cytochrome P450 in clinical pharmacokinetics: modulation by endogenous compounds. Clin Pharmacokinet 43:693-706.
    • (2004) Clin Pharmacokinet , vol.43 , pp. 693-706
    • Gervasini, G.1    Carrillo, J.A.2    Benitez, J.3
  • 11
    • 0035883891 scopus 로고    scopus 로고
    • Heterologous expression of cytochrome P450 2D6 mutants, electron transfer, and catalysis of bufuralol hydroxylation: The role of aspartate 301 in structural integrity
    • Hanna IH, Kim MS, and Guengerich FP (2001) Heterologous expression of cytochrome P450 2D6 mutants, electron transfer, and catalysis of bufuralol hydroxylation: the role of aspartate 301 in structural integrity. Arch Biochem Biophys 393:255-261.
    • (2001) Arch Biochem Biophys , vol.393 , pp. 255-261
    • Hanna, I.H.1    Kim, M.S.2    Guengerich, F.P.3
  • 12
    • 0031822496 scopus 로고    scopus 로고
    • Role of the alanine at position 363 of cytochrome P450 2B2 in influencing the NADPH- and hydroperoxide-supported activities
    • Hanna IH, Teiber JF, Kokones KL, and Hollenberg PF (1998) Role of the alanine at position 363 of cytochrome P450 2B2 in influencing the NADPH- and hydroperoxide-supported activities. Arch Biochem Biophys 350:324-332.
    • (1998) Arch Biochem Biophys , vol.350 , pp. 324-332
    • Hanna, I.H.1    Teiber, J.F.2    Kokones, K.L.3    Hollenberg, P.F.4
  • 13
    • 13544249943 scopus 로고    scopus 로고
    • Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): Clinical consequences, evolutionary aspects and functional diversity
    • Ingelman-Sundberg M (2005) Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J 5:6-13.
    • (2005) Pharmacogenomics J , vol.5 , pp. 6-13
    • Ingelman-Sundberg, M.1
  • 14
    • 0037160078 scopus 로고    scopus 로고
    • Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides
    • Kozak KR, Crews BC, Morrow JD, Wang LH, Ma YH, Weinander R, Jakobsson PJ, and Marnett LJ (2002) Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. J Biol Chem 277:44877-44885.
    • (2002) J Biol Chem , vol.277 , pp. 44877-44885
    • Kozak, K.R.1    Crews, B.C.2    Morrow, J.D.3    Wang, L.H.4    Ma, Y.H.5    Weinander, R.6    Jakobsson, P.J.7    Marnett, L.J.8
  • 17
    • 0027464041 scopus 로고
    • Relationship between personality and debrisoquine hydroxylation capacity: Suggestion of an endogenous neuroactive substrate or product of the cytochrome P4502D6
    • Llerena A, Edman G, Cobaleda J, Benítez J, Schalling D, and Bertilsson L (1993) Relationship between personality and debrisoquine hydroxylation capacity: suggestion of an endogenous neuroactive substrate or product of the cytochrome P4502D6. Acta Psychiatr Scand 87:23-28.
    • (1993) Acta Psychiatr Scand , vol.87 , pp. 23-28
    • Llerena, A.1    Edman, G.2    Cobaleda, J.3    Benítez, J.4    Schalling, D.5    Bertilsson, L.6
  • 19
    • 0036736195 scopus 로고    scopus 로고
    • Regional and cellular expression of CYP2D6 in human brain: Higher levels in alcoholics
    • Miksys S, Rao Y, Hoffmann E, Mash DC, and Tyndale RF (2002) Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics. J Neurochem 82:1376-1387.
    • (2002) J Neurochem , vol.82 , pp. 1376-1387
    • Miksys, S.1    Rao, Y.2    Hoffmann, E.3    Mash, D.C.4    Tyndale, R.F.5
  • 20
    • 33748703859 scopus 로고    scopus 로고
    • The endocannabinoid system as an emerging target of pharmacotherapy
    • Pacher P, Bátkai S, and Kunos G (2006) The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 58:389-462.
    • (2006) Pharmacol Rev , vol.58 , pp. 389-462
    • Pacher, P.1    Bátkai, S.2    Kunos, G.3
  • 21
    • 0026546189 scopus 로고
    • Diagnostic use of molecular probes before and after marrow transplantation
    • Petersdorf EW and Deeg HJ (1992) Diagnostic use of molecular probes before and after marrow transplantation. Clin Lab Med 12:113-128.
    • (1992) Clin Lab Med , vol.12 , pp. 113-128
    • Petersdorf, E.W.1    Deeg, H.J.2
  • 24
    • 0035049437 scopus 로고    scopus 로고
    • Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain
    • Siegle I, Fritz P, Eckhardt K, Zanger UM, and Eichelbaum M (2001) Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain. Pharmacogenetics 11:237-245.
    • (2001) Pharmacogenetics , vol.11 , pp. 237-245
    • Siegle, I.1    Fritz, P.2    Eckhardt, K.3    Zanger, U.M.4    Eichelbaum, M.5
  • 25
    • 34247281597 scopus 로고    scopus 로고
    • Anandamide metabolism by human liver and kidney microsomal cytochrome P450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides
    • Snider NT, Kornilov AM, Kent UM, and Hollenberg PF (2007) Anandamide metabolism by human liver and kidney microsomal cytochrome P450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides. J Pharmacol Exp Ther 321:590-597.
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 590-597
    • Snider, N.T.1    Kornilov, A.M.2    Kent, U.M.3    Hollenberg, P.F.4
  • 26
    • 21344439081 scopus 로고    scopus 로고
    • Fatty acid amidohydrolase in human neocortex-activity in epileptic and non-epileptic brain tissue and inhibition by putative endocannabinoids
    • Steffens M, Schulze-Bonhage A, Surges R, and Feuerstein TJ (2005) Fatty acid amidohydrolase in human neocortex-activity in epileptic and non-epileptic brain tissue and inhibition by putative endocannabinoids. Neurosci Lett 385:13-17.
    • (2005) Neurosci Lett , vol.385 , pp. 13-17
    • Steffens, M.1    Schulze-Bonhage, A.2    Surges, R.3    Feuerstein, T.J.4
  • 28
  • 29
    • 38849174512 scopus 로고    scopus 로고
    • Prostamides (prostaglandin-ethanolamides) and their pharmacology
    • Woodward DF, Liang Y, and Krauss AH (2008) Prostamides (prostaglandin-ethanolamides) and their pharmacology. Br J Pharmacol 153:410-419.
    • (2008) Br J Pharmacol , vol.153 , pp. 410-419
    • Woodward, D.F.1    Liang, Y.2    Krauss, A.H.3
  • 31
    • 3042515935 scopus 로고    scopus 로고
    • Polymorphic cytochrome P450 2D6: Humanized mouse model and endogenous substrates
    • Yu AM, Idle JR, and Gonzalez FJ (2004) Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates. Drug Metab Rev 36:243-277.
    • (2004) Drug Metab Rev , vol.36 , pp. 243-277
    • Yu, A.M.1    Idle, J.R.2    Gonzalez, F.J.3
  • 32
    • 0038240578 scopus 로고    scopus 로고
    • Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase
    • Yu AM, Idle JR, Herraiz T, Küpfer A, and Gonzalez FJ (2003b) Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase. Pharmacogenetics 13:307-319.
    • (2003) Pharmacogenetics , vol.13 , pp. 307-319
    • Yu, A.M.1    Idle, J.R.2    Herraiz, T.3    Küpfer, A.4    Gonzalez, F.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.