Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol

Biochemical Journal

Volumn 316, Issue 2, 1996, Pages 647-654

  Ellis, S Wynne ^a   Rowland, Karen ^a   Ackland, Mark J ^b   Rekka, Eleni ^c   Simula, Anthony P ^d   Lennard, Martin S ^a   Wolf, C Roland ^d   Tucker, Geoffrey T ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b Upjohn Laboratories Europe   (United Kingdom)

^c ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^d UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOCHROME P450; DRUG METABOLIZING ENZYME; METOPROLOL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DEMETHYLATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG OXIDATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

BACTERIA (MICROORGANISMS); SACCHAROMYCES CEREVISIAE;

EID: 0029999399     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj3160647     Document Type: Article

References (41)

1. Eichelbaum, M. and Gross, A. S. (1990) Pharmacol. Ther. 46, 377-394
2. Tucker, G. T. (1994) J. Pharm. Pharmacol. 46, 417-424
3. Tucker, G. T., Lennard, M. S., Ellis, S. W., Woods, H. F., Cho, A. K., Lin, L. Y., Hiratsuka, A., Schmitz, D. A. and Chu, T. Y. Y. (1994) Biochem. Pharmacol. 47, 1151-1156
4. Mahgoub, A., Idle, J. R., Dring, L. G., Lancaster, R. and Smith, R. L. (1977) Lancet I, 584-586
5. Tucker, G. T., Silas, J. H., Iyun, A. O., Lennard, M. S. and Smith, A. J. (1977) Lancet ii, 718
6. Eichelbaum, M., Spannbruker, N., Steincke, B. and Dengler, J. J. (1979) Eur. J. Clin. Pharmacol. 16, 183-187
7. Gough, A. C., Miles, J. S., Spurr, N. K., Moss, J. E., Gaedigk, A., Eichelbaum, M. and Wolf, C. R. (1990) Nature (London) 347, 773-776
8. Gonzalez, F. J. and Meyer, U. A. (1991) Clin. Pharmacol. Ther. 50, 233-238
9. Broly, F., Gaedigk, A., Heim, M., Eichelbaum, M., Morike, K. and Meyer, U. A. (1991) DNA Cell Biol. 10, 545-558
10. Saxena, R., Shaw, G. L., Relling, M. W., Frame, J. N., Moir, D. T., Evans, W. E., Caporaso, N. and Weiffenbach, B. (1994) Hum. Mol. Genet. 3, 923-926
11. Evert, B., Griese, E.-U. and Eichelbaum, M. (1994) Naunyn-Schmiedeberg's Arch. Pharmacol. 350, 434-439
12. Gonzalez, F. J., Skoda, R. C., Kimura, S., Umeno, M., Zanger, U., Nebert, D. W., Gelboin, H. V., Hardwick, J. P. and Meyer, U. A. (1988) Nature (London) 331, 442-446
13. Kimura, S., Umeno, M., Skoda, R. C., Meyer, U. A. and Gonzalez, F. J. (1989) Am. J. Hum. Genet. 45, 889-904
14. Ellis, S. W., Ching, M. S., Watson, P. F., Henderson, C. J., Simula, A. P., Lennard, M. S., Tucker, G. T. and Woods, H. F. (1992) Biochem. Pharmacol. 44, 617-620
15. Ellis, S. W., Rowland, K., Harlow, J. R., Simula, A. P., Lennard, M. S., Woods, H. F., Tucker, G. T. and Wolf, C. R. (1994) Br. J. Pharmacol. 112, 244P
16. Gotoh, O. (1992) J. Biol. Chem. 267, 83-90
17. Korzekwa, K. R. and Jones, J. P. (1993) Pharmacogenetics 3, 1-18
18. Lewis, D. F. V. (1995) Xenobiotica 25, 333-366
19. Hasemann, C. A., Kurumbail, R. G., Boddupalli, S. S., Peterson, J. A. and Deisenhofer, J. (1995) Structure 3, 41 -62
20. Poulos, T. L., Finzel, B. C. and Howard, A. J. (1987) J. Mol. Biol. 195, 687-700
21. Ravichandran, K. G., Boddupalli, S. S., Hasemann, C. A., Peterson, J. A. and Deisenhofer, J. (1993) Science 261, 731-736
22. Hasemann, C. A., Ravichandran, K. G., Peterson, J. A. and Deisenhofer, J. (1994) J. Mol. Biol. 236, 1169-1185
23. Koymans, L. M. H., Vermeulen, N. P. E., Baarslag, A. and Donne-Op den Kelder, G. M. (1993) J. Comput.-Aided Mol. Design 7, 281-289
24. Otton, S. V., Crewe, H. K., Lennard, M. S., Tucker, G. T. and Woods, H. F. (1988) J. Pharmacol. Exp. Ther. 247, 242-247
25. Williams, M. L., Lennard, M. S., Martin, I. J. and Tucker, G. T. (1994) Carcinogenesis 15, 2733-2738
26. Sambrook, J., Fritsch, E. F. and Maniatis, T. (1989) Molecular Cloning, a Laboratory Manual. 2nd edn., Cold Spring Harbour Laboratory Press. Cold Spring Harbour
27. Becker, D. M. and Guarente, L. (1991) Methods Enzymol. 194, 182-187
28. Shaw, L., Lennard, M. S., Tucker, G. T., Bax, N. D. S. and Woods, H. F. (1987) Biochem. Pharmacol. 36, 2283-2288
29. Omura, T. and Sato, R. (1964) J. Biol. Chem. 239, 2370-2378
30. Jefcoate, C. R. (1978) Methods Enzymol. 52, 258-279
31. Bernstein, F. C., Koetzle, T. F., Williams, G. J. B., Meyer, E. F., Brice, M. D., Rodgers, J. R., Kennard, O., Shimanouchi, T. and Tasumi, M. (1977) J. Mol. Biol. 112, 535-542
32. Weiner, S. J., Kollman, P. A., Case, D. A., Chandra Singh, U., Ghio, C., Alagona, G., Profeta, S., Jr. and Weiner, P. (1984) J. Amer. Chem. Soc. 106, 765-784
33. Islam, S. A., Wolf, C. R., Lennard, M. S. and Sternberg, M. J. E. (1991) Carcinogenesis 12, 2211-2219
34. Wolff, T., Distlerath, L. M., Worthington, M. T., Groopman, J. D., Hammons, G. J., Kadlubar, F. F., Prough, R. A., Martin, M. V. and Guengerich, F. P. (1985) Cancer Res. 45, 2116-2122
35. Ellis, S. W., Hayhurst, G. P., Smith, G., Lightfoot, T., Wong, M. M. S., Simula, A. P., Ackland, M. J., Sternberg, M. J. E., Lennard, M. S., Tucker, G. T. and Wolf, C. R. (1995) J. Biol. Chem. 270, 29055-29058
36. Meyer, U. A., Gut, J., Kronbach, T., Skoda, C., Meier, U. T. and Catin, T. (1986) Xenobiotica 16, 449-464
37. Koymans, L. M. H., Vermeulen, N. P. E., Van Acker, S. A. B. E., Te Koppele, J. M., Heykants, J. J. P., Lavtijsen, K., Meuldermans, W. and Donne-Op den Kelder, G. M. (1992) Chem. Res. Toxicol. 5, 211-219
38. Cupp-Vickery, J. R. and Poulos, T. L. (1995) Struc. Biol. 2, 144-153
39. Ouzonis, C. A. and Melvin, W. T. (1991) Eur. J. Biochem. 198, 307-315
40. Kim, M., Shen, D. D., Eddy. A. C. and Nelson, W. L. (1993) Drug Metab. Dispos. 21, 309-317
41. Mautz, D. S., Nelson, W. L. and Shen, D. D. (1995) Drug Metab. Dispos. 23, 513-517