Change in enantioselectivity in bufuralol 1″-hydroxylation by the substitution of phenylalanine-120 by alanine in cytochrome P450 2D6

Chirality

Volumn 17, Issue 1, 2005, Pages 37-43

  Masuda, Kazufumi ^a   Tamagake, Keietsu ^a   Okuda, Yukie ^a   Torigoe, Fumihiro ^a   Tsuzuki, Daisuke ^a   Isobe, Takashi ^a   Hichiya, Hiroyuki ^a   Hanioka, Nobumitsu ^a   Yamamoto, Shigeo ^a   Narimatsu, Shizuo ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Bufuralol enantiomer; CYP2D6; Glutamic acid 222; Phenylalanine 120; Substrate enantioselectivity

Indexed keywords

ALANINE; BUFURALOL; BUNITROLOL; COMPLEMENTARY DNA; CYTOCHROME P450 2D6; DEBRISOQUINE; PHENYLALANINE;

ARTICLE; BINDING KINETICS; CELL TRANSFORMATION; CHIRALITY; COMPUTER MODEL; CONCENTRATION RESPONSE; DNA DETERMINATION; DRUG OXIDATION; ENANTIOSELECTIVITY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME SUBSTRATE; GENE MUTATION; HYDROXYLATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY; SUBSTITUTION REACTION; WILD TYPE; YEAST CELL;

ALANINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2D6; ETHANOLAMINES; HYDROXYLATION; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; STEREOISOMERISM;

EID: 10844274767     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/chir.20092     Document Type: Article

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