In vitro metabolism of the analgesic bicifadine in the mouse, rat, monkey, and human

Drug Metabolism and Disposition

Volumn 35, Issue 12, 2007, Pages 2232-2241

  Erickson, David A ^a   Hollfelder, Stacy ^a   Tenge, Justin ^a   Gohdes, Mark ^a   Burkhardt, Jeffrey J ^a   Krieter, Philip A ^b  

^a 206 Carnegie Center   (United States)

^b DOV Pharmaceutical Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; ANALGESIC AGENT; BICIFADINE; CARBON 14; CLORGYLINE; COMPLEMENTARY DNA; CYTOCHROME P450 1A2; CYTOCHROME P450 2D6; CYTOCHROME P450 INHIBITOR; MONOAMINE OXIDASE A INHIBITOR; MONOAMINE OXIDASE B INHIBITOR; PERPHENAZINE; PHTHALAZINE DERIVATIVE; QUINIDINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SELEGILINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER METABOLISM; LIVER MICROSOME; LIVER MICROSOME METABOLISM; MONKEY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOMETRY; RAT; SPECIES COMPARISON; SPECIES DIFFERENCE; TANDEM MASS SPECTROMETRY;

ANALGESICS; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CARBON RADIOISOTOPES; CARBOXYLIC ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLORGYLINE; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2D6; ENZYME INHIBITORS; FEMALE; GLUCURONIDES; HEPATOCYTES; HUMANS; HYDROXYLATION; LACTAMS; LIVER; MACACA FASCICULARIS; MALE; MICE; MICROSOMES, LIVER; MIDDLE AGED; MITOCHONDRIA, LIVER; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; NADP; OXIDATION-REDUCTION; QUINIDINE; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SELEGILINE; SPECIES SPECIFICITY; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 36349034616     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.016055     Document Type: Article

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