Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes

Journal of Pharmacology and Experimental Therapeutics

Volumn 284, Issue 2, 1998, Pages 437-442

  Nakamura, Katsunori ^a   Yokoi, Tsuyoshi ^a   Kodama, Takao ^d   Inoue, Kazuaki ^c   Nagashima, Kazuo ^b   Shimada, Noriaki ^e   Shimizu, Toshiaki ^f   Kamataki, Tetsuya ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

^d Hokkaido Assoc Med Serv Workers   (Japan)

^e DAIICHI PURE CHEMICALS CO LTD   (Japan)

^f ASAHI CHEMICAL INDUSTRY CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; MEQUITAZINE; OXYGENASE; PROPRANOLOL; QUINIDINE;

ARTICLE; CATALYSIS; DRUG BLOOD LEVEL; DRUG HYDROXYLATION; DRUG INHIBITION; DRUG METABOLISM; DRUG OXIDATION; DRUG TRANSFORMATION; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER MICROSOME; PRIORITY JOURNAL;

EID: 0031885943     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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