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Volumn 26, Issue 11, 1998, Pages 1096-1101

1- And 3-hydroxylations, in addition to 4-hydroxylation, of debrisoquine are catalyzed by cytochrome P450 2D6 in humans

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; DEBRISOQUINE;

EID: 0031739606     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (31)

References (15)
  • 1
    • 0030432585 scopus 로고    scopus 로고
    • Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles
    • Aklillu E, Persson I, Bertilsson L, Johansson I, Rodriguez F and Ingelman-Sundberg M (1996) Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. J Pharmacol Exp Ther 278:441-446.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 441-446
    • Aklillu, E.1    Persson, I.2    Bertilsson, L.3    Johansson, I.4    Rodriguez, F.5    Ingelman-Sundberg, M.6
  • 2
    • 0017062435 scopus 로고
    • Metabolism of debrisoquine sulphate in rat, dog and man
    • Allen JG, Brown AN and Marten TR (1976) Metabolism of debrisoquine sulphate in rat, dog and man. Xenobiotica 6:405-409.
    • (1976) Xenobiotica , vol.6 , pp. 405-409
    • Allen, J.G.1    Brown, A.N.2    Marten, T.R.3
  • 3
    • 0016835230 scopus 로고
    • Metabolism of debrisoquine sulfate: Identification of some urinary metabolites in rat and man
    • Allen JG, East PB, Francis RJ and Haigh JL (1975) Metabolism of debrisoquine sulfate: identification of some urinary metabolites in rat and man. Drug Metab Dispos 3:332-337.
    • (1975) Drug Metab Dispos , vol.3 , pp. 332-337
    • Allen, J.G.1    East, P.B.2    Francis, R.J.3    Haigh, J.L.4
  • 4
    • 0025572192 scopus 로고
    • Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations
    • Alvan G, Bechtel P, Iselius L, and Gundert-Remy U (1990) Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations. Eur J Clin Pharmacol 39:533-537.
    • (1990) Eur J Clin Pharmacol , vol.39 , pp. 533-537
    • Alvan, G.1    Bechtel, P.2    Iselius, L.3    Gundert-Remy, U.4
  • 6
    • 0029064096 scopus 로고
    • Ultrarapid hydroxylation of debrisoquine in a Swedish population: Analysis of the molecular genetic basis
    • Dahl ML, Johansson I, Bertilsson L, Ingelman-Sundberg M and Sjöqvist F (1995) Ultrarapid hydroxylation of debrisoquine in a Swedish population: analysis of the molecular genetic basis. J Pharmacol Exp Ther 274:516-520.
    • (1995) J Pharmacol Exp Ther , vol.274 , pp. 516-520
    • Dahl, M.L.1    Johansson, I.2    Bertilsson, L.3    Ingelman-Sundberg, M.4    Sjöqvist, F.5
  • 7
    • 0023943597 scopus 로고
    • Enantioselectivity of 4-hydroxylation in extensive and poor metabolizers of debrisoquine
    • Eichelbaum M, Bertilsson L, Küpfer A, Steiner E and Meese CO (1988) Enantioselectivity of 4-hydroxylation in extensive and poor metabolizers of debrisoquine. Br J Clin Pharmacol 25:505-508.
    • (1988) Br J Clin Pharmacol , vol.25 , pp. 505-508
    • Eichelbaum, M.1    Bertilsson, L.2    Küpfer, A.3    Steiner, E.4    Meese, C.O.5
  • 8
    • 0025305464 scopus 로고
    • The genetic polymorphism of debrisoquine/sparteine metabolism: Clinical aspects
    • Eichelbaum M and Gross AS (1990) The genetic polymorphism of debrisoquine/sparteine metabolism: clinical aspects. Pharmacol Ther 46:377-394.
    • (1990) Pharmacol Ther , vol.46 , pp. 377-394
    • Eichelbaum, M.1    Gross, A.S.2
  • 10
    • 0018900001 scopus 로고
    • A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population
    • Evans DA, Mahgoub A, Sloan TP, Idle JR and Smith RL (1980) A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population. J Med Genet 17:102-105.
    • (1980) J Med Genet , vol.17 , pp. 102-105
    • Evans, D.A.1    Mahgoub, A.2    Sloan, T.P.3    Idle, J.R.4    Smith, R.L.5
  • 12
    • 0027136288 scopus 로고
    • Inherited amplification of an active gene in the cytochrome P450 CYP2D-locus as a cause of ultrarapid metabolism of debrisoquine
    • Johansson I, Lundqvist E, Bertilsson L, Dahl ML, Sjöqvist F and Ingelman-Sundberg M (1993) Inherited amplification of an active gene in the cytochrome P450 CYP2D-locus as a cause of ultrarapid metabolism of debrisoquine. Proc Natl Acad Sci USA 90:11825-11829.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11825-11829
    • Johansson, I.1    Lundqvist, E.2    Bertilsson, L.3    Dahl, M.L.4    Sjöqvist, F.5    Ingelman-Sundberg, M.6
  • 15
    • 0027314831 scopus 로고
    • Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: Molecular modelling and inhibition studies
    • Strobl GR, von Kreudener S, Stöckigt J, Guengerich FP and Wolff T (1993) Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modelling and inhibition studies. J Med Chem 36:1136-1145.
    • (1993) J Med Chem , vol.36 , pp. 1136-1145
    • Strobl, G.R.1    Von Kreudener, S.2    Stöckigt, J.3    Guengerich, F.P.4    Wolff, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.