Identification and analysis of conserved sequence motifs in cytochrome P450 family 2: Functional and structural role of a motif187 RFDYKD 192 in CYP2B enzymes

Journal of Biological Chemistry

Volumn 283, Issue 31, 2008, Pages 21808-21816

  Oezguen, Numan ^b   Kumar, Santosh ^a   Hindupur, Aditya ^b   Braun, Werner ^b   Muralidhara, B K ^c   Halpert, James R ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSTS; ENZYMES; HYDROGEN; MICROBIAL FUEL CELLS; PROTEINS; SUBSTRATES; THERMODYNAMIC STABILITY;

2 SEQUENCES; GENETIC VARIANTS; LONG RANGES; METHOXY; MULTIPLE ALIGNMENTS; NEGATIVE CONTROLS; ON SITES; RANK ORDERS; SEQUENCE MOTIFS; SUBSTRATE SPECIFICITIES; THERMAL STABILITIES; TRIFLUORO METHYLS;

HYDROGEN BONDS;

ARGININE; ASPARAGINE; ASPARTIC ACID; BIFONAZOLE; COUMARIN; COUMARIN DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 2B; CYTOCHROME P450 2B4; GLUTAMIC ACID; IMIDAZOLE DERIVATIVE; MUTANT PROTEIN; TESTOSTERONE; TYROSINE; VALINE; CYTOCHROME P 450 CYP2B4 (RABBIT); CYTOCHROME P-450 CYP2B4 (RABBIT); UNSPECIFIC MONOOXYGENASE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA TEMPLATE; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME SPECIFICITY; GENE IDENTIFICATION; GENE MUTATION; GENETIC ANALYSIS; GENETIC VARIABILITY; HYDROGEN BOND; MOLECULAR INTERACTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MOTIF; TEMPERATURE; THERMOSTABILITY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; IC 50; KINETICS; MUTATION; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

AMINO ACID MOTIFS; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CATALYSIS; CONSERVED SEQUENCE; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; TEMPERATURE;

EID: 52049106404     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708582200     Document Type: Article

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