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Volumn 27, Issue 1, 1997, Pages 111-125

Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; CYTOCHROME P450 ISOENZYME; QUINIDINE; RECOMBINANT ENZYME;

EID: 0031014344     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/004982597240802     Document Type: Article
Times cited : (107)

References (41)
  • 1
    • 0023942901 scopus 로고
    • Chemical oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its in vivo metabolism in rat brain and liver
    • ARORA, P. K., RIACHI, N. J., HARIK, S. I. and SAYRE, L. M., 1988, Chemical oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its in vivo metabolism in rat brain and liver. Biochemical and Biophysical Research Communications, 152, 1339-1347.
    • (1988) Biochemical and Biophysical Research Communications , vol.152 , pp. 1339-1347
    • Arora, P.K.1    Riachi, N.J.2    Harik, S.I.3    Sayre, L.M.4
  • 2
    • 0021829406 scopus 로고
    • Permanent human parkinsonism due to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): Seven cases
    • BALLARD, P. A., TETRUD, J. W. and LANGSTON, J. W., 1985, Permanent human parkinsonism due to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): seven cases. Neurology, 35, 949-956.
    • (1985) Neurology , vol.35 , pp. 949-956
    • Ballard, P.A.1    Tetrud, J.W.2    Langston, J.W.3
  • 3
    • 0022408175 scopus 로고
    • Ecogenetics of Parkinson's disease: 4-hydroxylation of debrisoquine
    • BARBEAU, A., CLOUTIER, T., ROY, M., PLASSE, L., PARIS, S. and POIRER, J., 1987, Ecogenetics of Parkinson's disease: 4-hydroxylation of debrisoquine. Lancet, ii, 1213-1216.
    • (1987) Lancet , vol.2 , pp. 1213-1216
    • Barbeau, A.1    Cloutier, T.2    Roy, M.3    Plasse, L.4    Paris, S.5    Poirer, J.6
  • 6
    • 0022634053 scopus 로고
    • Contribution of N-oxygenation to the metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) by various liver preparations
    • CASHMAN, J. R. and ZIEGLER, D. M., 1985, Contribution of N-oxygenation to the metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) by various liver preparations. Molecular Pharmacology, 29, 163-167.
    • (1985) Molecular Pharmacology , vol.29 , pp. 163-167
    • Cashman, J.R.1    Ziegler, D.M.2
  • 7
    • 0023687420 scopus 로고
    • Characterization of hepatic microsomal metabolism as an in vivo detoxification pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyndine in mice
    • CHIBA, K., KUBOTA, E., MIYAKAWA, T., KATO, Y. and ISHIZAKI, T., 1988, Characterization of hepatic microsomal metabolism as an in vivo detoxification pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyndine in mice. Journal of Pharmacology and Experimental Therapeutics, 246, 1108-1115.
    • (1988) Journal of Pharmacology and Experimental Therapeutics , vol.246 , pp. 1108-1115
    • Chiba, K.1    Kubota, E.2    Miyakawa, T.3    Kato, Y.4    Ishizaki, T.5
  • 8
    • 0030436624 scopus 로고    scopus 로고
    • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4 - Implications for susceptibility to Parkinson's Disease
    • COLEMAN, T., ELLIS, S. W., MARTIN, I. J., LENNARD, M. S. and TUCKER, G. T., 1996, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4 - implications for susceptibility to Parkinson's Disease. Journal of Pharmacology and Experimental Therapeutics, 277, 685-690.
    • (1996) Journal of Pharmacology and Experimental Therapeutics , vol.277 , pp. 685-690
    • Coleman, T.1    Ellis, S.W.2    Martin, I.J.3    Lennard, M.S.4    Tucker, G.T.5
  • 9
    • 0023568113 scopus 로고
    • MPTP, the neurotoxin inducing Parkinson's Disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation
    • FONNE-PFISTER, R, BARGETZI, M. J. and MEYER, U. A., 1987, MPTP, the neurotoxin inducing Parkinson's Disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation. Biochemical and Biophysical Research Communications, 148, 1144-1150.
    • (1987) Biochemical and Biophysical Research Communications , vol.148 , pp. 1144-1150
    • Fonne-Pfister, R.1    Bargetzi, M.J.2    Meyer, U.A.3
  • 12
    • 0025114258 scopus 로고
    • Identification of the primary gene defect at the cytochrome P450 CYP2D locus
    • GOUGH, A. C., MILES, J. S., MOSS, J. E., GAEDIGK, A., EICHELBAUM, M. and WOLF, C. R., 1990, Identification of the primary gene defect at the cytochrome P450 CYP2D locus. Nature, 347, 773-776.
    • (1990) Nature , vol.347 , pp. 773-776
    • Gough, A.C.1    Miles, J.S.2    Moss, J.E.3    Gaedigk, A.4    Eichelbaum, M.5    Wolf, C.R.6
  • 14
    • 0021215509 scopus 로고
    • Presence of NADPH-cytochrome P450 reductase in central catecholaminergic neurones
    • HAGLUND, L., KOHLER, C., HAAPARANTA, T., GOLDSTEIN, M. and GUSTAFSSON, J. A., 1984, Presence of NADPH-cytochrome P450 reductase in central catecholaminergic neurones. Nature, 307, 259-262.
    • (1984) Nature , vol.307 , pp. 259-262
    • Haglund, L.1    Kohler, C.2    Haaparanta, T.3    Goldstein, M.4    Gustafsson, J.A.5
  • 15
    • 0025612231 scopus 로고
    • Molecular mechanisms of drug resistance
    • HAYES, J. D. and WOLF, C. R., 1990, Molecular mechanisms of drug resistance. Biochemical Journal, 272, 281-295.
    • (1990) Biochemical Journal , vol.272 , pp. 281-295
    • Hayes, J.D.1    Wolf, C.R.2
  • 17
    • 0023258883 scopus 로고
    • High-performance liquid chromatography assays for bufuralol 1′-hydroxylase, debrisoquine 4′-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver
    • KRONBACH, T., MATHYS, D., GUT, J., CATIN, T. and MEYER, U. A., 1987, High-performance liquid chromatography assays for bufuralol 1′-hydroxylase, debrisoquine 4′-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver. Analytical Biochemistry, 162, 24-32.
    • (1987) Analytical Biochemistry , vol.162 , pp. 24-32
    • Kronbach, T.1    Mathys, D.2    Gut, J.3    Catin, T.4    Meyer, U.A.5
  • 18
    • 0025966995 scopus 로고
    • MPTP-induced ATP depletion and cell death in neuroblastoma x glioma hybrid NG 108-15 cells: Protection by glucose and sensitization by tetraphenylborate
    • KUTTY, R. K., SANTOSTASI, G., HORNG, J. and KRISHNA, G., 1991, MPTP-induced ATP depletion and cell death in neuroblastoma x glioma hybrid NG 108-15 cells: protection by glucose and sensitization by tetraphenylborate. Toxicology and Applied Pharmacology, 107, 377-388.
    • (1991) Toxicology and Applied Pharmacology , vol.107 , pp. 377-388
    • Kutty, R.K.1    Santostasi, G.2    Horng, J.3    Krishna, G.4
  • 23
    • 0025819615 scopus 로고
    • Protection and potentiation of MPTP-induced toxicity by cytochrome P-450 inhibitors and inducer: In vitro studies with brain slices
    • PAI, K. S. and RAVINDRANATH, V., 1991, Protection and potentiation of MPTP-induced toxicity by cytochrome P-450 inhibitors and inducer: in vitro studies with brain slices. Brain Research, 555, 239-244.
    • (1991) Brain Research , vol.555 , pp. 239-244
    • Pai, K.S.1    Ravindranath, V.2
  • 24
    • 0029986770 scopus 로고    scopus 로고
    • Functional high level expression of cytochrome P450 CYP2D6 using baculoviral expression systems
    • PAINE, M. J. I., GILHAM, D., ROBERTS, G. C. K. and WOLF, C. R., 1996, Functional high level expression of cytochrome P450 CYP2D6 using baculoviral expression systems. Archives of Biochemistry and Biophysics, 328, 143-150.
    • (1996) Archives of Biochemistry and Biophysics , vol.328 , pp. 143-150
    • Paine, M.J.I.1    Gilham, D.2    Roberts, G.C.K.3    Wolf, C.R.4
  • 25
    • 0023279624 scopus 로고
    • Debrisoquine metabolism in Parkinsonian patients treated with antihistamine drugs
    • POIRER, J., ROY, M., CAMPANELLA, G., CLOUTIER, T. and PARIS, S., 1987, Debrisoquine metabolism in Parkinsonian patients treated with antihistamine drugs. Lancet, ii, 386.
    • (1987) Lancet , vol.2 , pp. 386
    • Poirer, J.1    Roy, M.2    Campanella, G.3    Cloutier, T.4    Paris, S.5
  • 26
    • 0018900001 scopus 로고
    • A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population
    • PRICE-EVANS, D. A., MAHGOUB, A., SLOAN, T. P., IDLE, J. R. and SMITH, R. L., 1980, A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population. Journal of Medical Genetics, 17, 102-105.
    • (1980) Journal of Medical Genetics , vol.17 , pp. 102-105
    • Price-Evans, D.A.1    Mahgoub, A.2    Sloan, T.P.3    Idle, J.R.4    Smith, R.L.5
  • 27
    • 0021736752 scopus 로고
    • Oxidation of the neurotoxic amine 1-mehtyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTP
    • SALACH, J. I., SINGER, T. P., CASTAGNOLI, JR, N. and TREVOR, A., 1984, Oxidation of the neurotoxic amine 1-mehtyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTP. Biochemical and Biophysical Research Communications, 125, 831-835.
    • (1984) Biochemical and Biophysical Research Communications , vol.125 , pp. 831-835
    • Salach, J.I.1    Singer, T.P.2    Castagnoli Jr., N.3    Trevor, A.4
  • 28
    • 0024226783 scopus 로고
    • The localisation of laminin mRNA and protein in the postimplantation embryo and placenta of the mouse: An in situ hybridisation and immunohistochemical study
    • SENIOR, P. V., CRITCHLEY, D. R., BECK, F., WALKER, R. A. and VARLEY, J. M., 1988, The localisation of laminin mRNA and protein in the postimplantation embryo and placenta of the mouse: an in situ hybridisation and immunohistochemical study. Development, 104, 431-446.
    • (1988) Development , vol.104 , pp. 431-446
    • Senior, P.V.1    Critchley, D.R.2    Beck, F.3    Walker, R.A.4    Varley, J.M.5
  • 29
    • 0025087559 scopus 로고
    • Parkinson's disease and cytochrome P450: A possible link?
    • SHAHI, G. S., DAS, N. P. and MOOCHHALA, S. M., 1990, Parkinson's disease and cytochrome P450: a possible link? Medical Hypothesis, 32, 277-282.
    • (1990) Medical Hypothesis , vol.32 , pp. 277-282
    • Shahi, G.S.1    Das, N.P.2    Moochhala, S.M.3
  • 30
    • 0023649932 scopus 로고
    • Cation-exchange high performance liquid chromatography assay for the nigrostriatal oxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridme and its monoamine oxidase B generated metabolites in brain tissues
    • SHINKA, T., CASTAGNOLI, JR. N., WU, E. Y., HOAG, M. K. P. and TREVOR, A. J., 1987, Cation-exchange high performance liquid chromatography assay for the nigrostriatal oxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridme and its monoamine oxidase B generated metabolites in brain tissues. Journal of Chromatography, 398, 279-287.
    • (1987) Journal of Chromatography , vol.398 , pp. 279-287
    • Shinka, T.1    Castagnoli Jr., N.2    Wu, E.Y.3    Hoag, M.K.P.4    Trevor, A.J.5
  • 31
    • 0027319640 scopus 로고
    • Are poor metabolisers of sparteine/debrisoqume less pain tolerant than extensive metabolisers ?
    • SINDRUP, S. H., POULSEN, L., BROSEN, K., ARENDT-NIELSEN, L. and GRAM, L. F., 1993, Are poor metabolisers of sparteine/debrisoqume less pain tolerant than extensive metabolisers ? Pain, 537, 335-349.
    • (1993) Pain , vol.537 , pp. 335-349
    • Sindrup, S.H.1    Poulsen, L.2    Brosen, K.3    Arendt-Nielsen, L.4    Gram, L.F.5
  • 33
    • 0027215081 scopus 로고
    • Neurologic diseases associated with use of plant components with toxic potential
    • SPENCER, P. S., LUDOLPH, A. C. and KISBY, G. E., 1993, Neurologic diseases associated with use of plant components with toxic potential. Environmental Research, 62, 106-113.
    • (1993) Environmental Research , vol.62 , pp. 106-113
    • Spencer, P.S.1    Ludolph, A.C.2    Kisby, G.E.3
  • 34
    • 0028851742 scopus 로고
    • Parkinson's disease epidemiology in the Northampton District, England, 1992
    • SUTCLIFFE, R. L. G. and MEARA, J. R., 1995, Parkinson's disease epidemiology in the Northampton District, England, 1992. Acta Neurologica Scandinavia, 92, 443-450.
    • (1995) Acta Neurologica Scandinavia , vol.92 , pp. 443-450
    • Sutcliffe, R.L.G.1    Meara, J.R.2
  • 35
    • 0026165306 scopus 로고
    • Abnormal liver enzyme-mediated metabolism in Parkinson's disease: A second look
    • TANNER, C. M., 1991, Abnormal liver enzyme-mediated metabolism in Parkinson's disease: a second look. Neurology, 41 (suppl. 2), 89-91.
    • (1991) Neurology , vol.41 , Issue.2 SUPPL. , pp. 89-91
    • Tanner, C.M.1
  • 36
    • 0027354024 scopus 로고
    • Metabolic aspects of the behavior of MPTP and some analogues
    • TIPTON, K. F., MCCRODDEN, J. M. and SULLIVAN, J. P., 1993, Metabolic aspects of the behavior of MPTP and some analogues. Advances in Neurology, 60, 186-192.
    • (1993) Advances in Neurology , vol.60 , pp. 186-192
    • Tipton, K.F.1    Mccrodden, J.M.2    Sullivan, J.P.3
  • 37
    • 0028289040 scopus 로고
    • Clinical implications of genetic polymorphism in drug metabolism
    • TUCKER, G. T., 1994, Clinical implications of genetic polymorphism in drug metabolism. Journal of Pharmacy and Pharmacology, 46 (suppl. 1), 417-424.
    • (1994) Journal of Pharmacy and Pharmacology , vol.46 , Issue.1 SUPPL. , pp. 417-424
    • Tucker, G.T.1
  • 38
    • 0025779409 scopus 로고
    • Neuronal cytochrome P450IID1 (debrisoquine/sparteine-type): Potent inhibition of activity by (-)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6
    • TYNDALE, R. F., SUNAHARA, R., INABA, T., KALOW, W., GONZALEZ, F. J. and NIZIK, H. B., 1991, Neuronal cytochrome P450IID1 (debrisoquine/sparteine-type): potent inhibition of activity by (-)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6. Molecular Pharmacology, 40, 63-68.
    • (1991) Molecular Pharmacology , vol.40 , pp. 63-68
    • Tyndale, R.F.1    Sunahara, R.2    Inaba, T.3    Kalow, W.4    Gonzalez, F.J.5    Nizik, H.B.6
  • 40
    • 0025540484 scopus 로고
    • Metabolic factors in cancer susceptibility
    • WOLF, C. R., 1990, Metabolic factors in cancer susceptibility. Cancer Surveys, 9, 437-474.
    • (1990) Cancer Surveys , vol.9 , pp. 437-474
    • Wolf, C.R.1


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