Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6: Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectmty

Journal of Biological Chemistry

Volumn 276, Issue 43, 2001, Pages 39553-39561

  Hanna, Imad H ^a   Krauser, Joel A ^d   Cai, Hongliang ^b   Kim, Mi Sook ^a   Guengerich, F Peter ^c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b PFIZER INC   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Vanderbilt Univ School of Medicine ^*

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; CATALYSIS; ENZYMES; NITROGEN; OXIDATION;

REGIOSELECTIVITY;

BIOCHEMISTRY;

1' HYDROXYBUFURALOL; BENZENE DERIVATIVE; BUFURALOL; CUMENE HYDROPEROXIDE; CYTOCHROME P450 2D6; DEBRISOQUINE HYDROXYLASE; IODOSOBENZENE; METOPROLOL; N METHYL 1,4 PHENYL 1,2,5,6 TETRAHYDROPYRIDINE; NITROGEN; OXIDOREDUCTASE; OXYGENASE; PYRIDINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; UNCLASSIFIED DRUG; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYP3A PROTEIN, HUMAN; CYTOCHROME P450; CYTOCHROME P450 1A2; DOPAMINE RECEPTOR STIMULATING AGENT; ETHANOLAMINE DERIVATIVE; MIXED FUNCTION OXIDASE;

ALLOSTERISM; ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME METABOLISM; ENZYME SUBSTRATE; OXIDATION; PRIORITY JOURNAL; STEREOCHEMISTRY; CHEMICAL MODEL; CONFORMATION; METABOLISM; OXIDATION REDUCTION REACTION;

CANIS; LIA; PRIMULA;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ALLOSTERIC REGULATION; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; DOPAMINE AGENTS; ETHANOLAMINES; METOPROLOL; MIXED FUNCTION OXYGENASES; MODELS, CHEMICAL; MOLECULAR CONFORMATION; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDATION-REDUCTION;

EID: 0035955733     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106841200     Document Type: Article

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