Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2

Journal of Biological Chemistry

Volumn 282, Issue 19, 2007, Pages 14348-14355

  Sansen, Stefaan ^a   Yano, Jason K ^a,b   Reynald, Rosamund L ^a   Schoch, Guillaume A ^a,c   Griffin, Keith J ^a   Stout, C David ^a   Johnson, Eric F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Takeda San Diego Inc   (United States)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CELLS; OXIDATION; PROTEINS; SUBSTRATES;

DRUG OXIDATIONS; LIVERS; MICROSOMAL CYTOCHROME; XENOBIOTIC DETOXICATION;

POLYCYCLIC AROMATIC HYDROCARBONS;

ALPHA NAPHTHOFLAVONE; AROMATIC AMINE; CYTOCHROME P450 1A2; HEME; POLYCYCLIC AROMATIC HYDROCARBON; ALPHA-NAPHTHOFLAVONE; BENZOFLAVONE DERIVATIVE; ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ASSAY; ENZYME BINDING; ENZYME MECHANISM; ENZYME METABOLISM; ENZYME PURIFICATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROXYLATION; MICROSOME; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLIZATION; DRUG ANTAGONISM; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

BENZOFLAVONES; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 CYP1A2; ENZYME INHIBITORS; HUMANS; HYDROXYLATION; MODELS, MOLECULAR; OXIDATION-REDUCTION; PROTEIN CONFORMATION;

EID: 34347235844     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M611692200     Document Type: Article

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