Design, synthesis, and characterization of 7-methoxy-4- (aminomethyl)coumarin as a novel and selective cytochrome P450 2D6 substrate suitable for high-throughput screening

Chemical Research in Toxicology

Volumn 12, Issue 7, 1999, Pages 555-559

  Onderwater, Rob C A ^a   Venhorst, Jennifer ^a   Commandeur, Jan N M ^a   Vermeulen, Nico P E ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

7 METHOXY 4 (AMINOMETHYL)COUMARIN; COUMARIN DERIVATIVE; DEBRISOQUINE 4 HYDROXYLASE; QUINIDINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; ENZYME ACTIVITY; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; MICHAELIS MENTEN KINETICS; PROTEIN EXPRESSION; SYNTHESIS;

CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARINS; CYTOCHROME P-450 CYP2D6; HUMANS; KINETICS; MICROSOMES, LIVER; MODELS, MOLECULAR; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY;

EID: 0032876070     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx980248q     Document Type: Article

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